Interlinear differences in mice in production of migration inhibition factor toCandida albicans antigens

1983 ◽  
Vol 96 (4) ◽  
pp. 1437-1439 ◽  
Author(s):  
K. V. Vorob'ev ◽  
L. V. Gankovskaya ◽  
L. V. Koval'chuk ◽  
L. F. Shabanova
Keyword(s):  
Migration Inhibition Factor ◽  
Migration Inhibition ◽  
Inhibition Factor ◽  
Interlinear Differences

Production of Leukocyte Migration Inhibition Factor by Lymphocytes of Larynx Cancer Patients Stimulated by Laryngeal Carcinoma Solubilized Membrane Antigens

1982 ◽  
Vol 68 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Giorgio Cortesina ◽  
Giovanni Patrick Cavallo ◽  
Fabio Beatrice ◽  
Alberto Sartoris ◽  
Mario Bussi ◽  
...  
Keyword(s):  
Laryngeal Carcinoma ◽  
Normal Mucosa ◽  
Leukocyte Migration ◽  
Migration Inhibition Factor ◽  
Migration Inhibition ◽  
Inhibition Factor ◽  
Histocompatibility Complex ◽  
Laryngeal Mucosa ◽  
Leukocyte Migration Inhibition ◽  
Membrane Antigens

The production of leukocyte migration inhibition factor (LIF) from lymphocytes after stimulation with 3 M KCl soluble tumor and normal mucosa extracts was investigated in 30 patients with laryngeal carcinoma at different development stages and in 30 normal donors. The experiments were performed in heterologous and autologous systems. In heterologous systems 3 M KCl tumor extracts induced LIF production by heterologous lymphocytes from patients in 91 % of the cases, and normal mucosa extracts induced LIF production by heterologous lymphocytes from patients in 73 % of the cases and from normal donors in 90 % of the cases. In autologous systems 3 M KCl tumor extracts induced LIF production by autologous lymphocytes from the same patients in 65 % of the cases, whereas the normal laryngeal mucosa extracts induced LIF production by the same autologous lymphocytes in the 6 % of the cases. The high positivity percentage of the test in heterologous systems could be related to differences in the major histocompatibility complex. The 65 % test positivity in autologous systems using tumor extracts could be related to the presence of tumor associated antigens.

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