Determination of the probability of aggregation to assess the functional state of platelets

1981 ◽  
Vol 91 (4) ◽  
pp. 555-558
Author(s):  
R. A. Markosyan ◽  
Z. A. Gabbasov ◽  
A. Yu. Radin ◽  
E. G. Popov
Keyword(s):  
Functional State

Level of thyroid-stimulating hormone as basic diagnostic marker and criterion of treatment success of thyroid diseases

2017 ◽  
pp. 102-106
Author(s):  
V.I. Pankiv ◽  
Keyword(s):  
Key Words ◽  
Functional State ◽  
Diagnostic Marker ◽  
Treatment Success ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Diseases ◽  
Early Diagnostics ◽  
Basic Test ◽  
Stimulating Hormone

In the article information is generalized on the aspects of early diagnostics of thyrois disorders. The value of thyroid-stimulating hormone is underlined as basic test for determination of the thyroid functional state and criterion of treatment success of thyroid diseases. Key words: thyroid, thyroid-stimulating hormone, diagnostics.

scholarly journals THE IMPORTANCE OF THE FUNCTIONAL STATE OF THIOL-DISULFIDE UNIT OF THE ANTIOXIDANT SYSTEM IN THE ACUTE BACTERIAL DYSENTERY IN THE FORECAST OF THE COURSE AND THE SELECTION OF THE TREATMENT REGIMEN

2017 ◽  
Vol 22 (5) ◽  
pp. 258-263
Author(s):  
Zarema G. Tagirova
Keyword(s):  
Antimicrobial Peptides ◽  
Functional State ◽  
Antioxidant System ◽  
Disulfide Bonds ◽  
Severe Disease ◽  
Treatment Methods ◽  
Sh Groups ◽  
Group I ◽  
Antioxidant Agents

The goal was to optimize the treatment of shigellosis patients on the basis of an evaluation of the functional state of the thiol-disulfide unit of the antioxidant system (AOS) on a background of various treatment methods. Materials and methods. 400 patients with acute bacterial dysentery of varying severity of the course were observed; Shigella Flexner was isolated in 324(81%) cases, Shigella Sonne - in 76(19%) cases. The determination of sulfhydryl (SH-) groups and disulfide bonds (SS-) was carried out by the direct and reverse amperometric titration with the use of silver nitrate and unithiol in hemolysate. Three groups separated by random sampling were considered. In group I (122 patients), basic therapy was prescribed, including etiotropic and pathogenetic treatment. In group II (134 patients), pathogenetic treatment was prescribed in the combination with a complex of natural cytokines and antimicrobial peptides secreted by pig peripheral blood leukocytesa (»superlimph» preparation). In the third group (144 patients), the drug «superlimph» was prescribed along with etiotropic and pathogenetic treatment. Results. In acute bacterial dysentery disturbances of the redox balance were established to be correlated with the severity of the course in the form of a significant decrease in the level of SH-groups and the thiol-disulfide coefficient on the background of an increase in the level of SS-groups, which indicates to a decrease in the buffer capacity of the AOS. These data can serve as predictors of the nature of the course of dysentery. Comparative clinical evaluation of the effectiveness of various treatment methods revealed the most pronounced in severe disease advantages of complex therapy, including a combination of basic etiotropic, pathogenetic treatment with a complex of natural cytokines and antimicrobial peptides («superlimph»). Conclusion. The change in the ratio of oxidative processes to AOS occurs at any severity of dysentery, but in severe cases these changes acquire a qualitative character. In the survey standards for bacterial dysentery there is recommended to include the determination of indices of the thiol-disulfide unit, as an additional criterion for the severity of the course and the prognosis of the course of the disease. Exceeding the concentration of SS-groups of the concentration of SH-groups and the inversion of the thiol-disulfide coefficient as markers of the breakdown in AOS seem to be prognostically unfavorable factor. The severe course of acute bacterial dysentery is an indication for inclusion of antioxidant agents in the therapeutic complex. Based on the mechanism of revealed abnormalities in AOS, the use of a complex of natural cytokines and antimicrobial peptides («superlimph») can be considered as an immunocorrecting drug.

Adaptation of the ASTRIN staining technique for quantitative determination of the functional state of the cellular nucleus

1987 ◽  
Vol 81 (1) ◽  
pp. 95-IN2 ◽  
Author(s):  
Péter Kovács ◽  
György Csaba ◽  
László Kőhidai ◽  
Ottilie Török
Keyword(s):  
Quantitative Determination ◽  
Functional State ◽  
Staining Technique

Anatomo-functional state of organs of small tangs in poor responders

2018 ◽  
pp. 50-54
Author(s):  
G.V. Strelko ◽  
Keyword(s):  
Blood Flow ◽  
Functional Status ◽  
Vascular Resistance ◽  
Functional State ◽  
Color Doppler ◽  
Ovarian Response ◽  
Treatment Programs ◽  
Poor Responders ◽  
Surgical Interventions

The objective: study of the anatomical and functional status of the uterus and ovaries in poor responders in ART programs. Materials and methods. Determination of the anatomical features and functional status of the uterus and ovaries in «poor responders» to exclude a clinically significant pathology that would affect the success of the ART program was performed by ultrasound scanning with the study of topografts, sizes, contours, echostructure of the uterus and ovary and determination of the volume of the ovaries and the number of antral follicles. Blood flow in the vessels of the stroma of the ovaries, as one of the important criteria for assessing the possible ovarian response, was assessed using color Doppler mapping. Results. «Poor responders» patients have a smaller sise of ovaries and a reduced number of antral folicles, which can be explained by the surgical interventions carried out according to the type of ovarian resection and the cysts removal. In addition, during the transition from the follicular to luteal phase, there is no decrease in the vascular resistance of the dominant follicle, which slows the process of ovulation and reduces the likelihood of fertilization in conditions of increased vascular resistance. Conclusion. Ultrasound examination of the uterus and ovaries and doplerometric investigation of peryfollicular blood flow allows us to thoroughly approach both the evaluation of the ovarian response and the endometric readiness for implantation, which dictates the need for an individual selection of preconceptional preparation and treatment programs for ART. Key words: anatomical and functional state, pelvic organs, ovarian reserve, peryfollicular blood flow, poor responders.

scholarly journals Functional state of motor units of skeletal muscles in chronic diseases of motoneurons and their axones

1995 ◽  
Vol XXVII (1-2) ◽  
pp. 5-10
Author(s):  
L. F. Kasatkina
Keyword(s):  
Motor Neuron ◽  
Chronic Diseases ◽  
Functional State ◽  
Skeletal Muscles ◽  
Neuromuscular Diseases ◽  
Motor Units ◽  
Peripheral Motor ◽  
Partial Compensation

Electromyographic examination of the potentials of motor units in 498 patients with different forms of peripheral motor neuron pathology allowed to distinguish electromyographic criteria of estimation of the denervationreinnervation processes. Determination of phases of full, partial compensation and of decompensation phase may be used for examination of pathogenesis of neuromuscular diseases, their diagnosis and assessment of their progress.

QUANTITATIVE DETERMINATION OF SUCCINIC DEHYDROGENASE AS AN ESTIMATE OF THE FUNCTIONAL STATE OF THE RAT SEMINAL VESICLE

1962 ◽  
Vol 39 (1) ◽  
pp. 129-134
Author(s):  
Antti Telkkä ◽  
A. Kivikoski ◽  
Väinö K. Hopsu
Keyword(s):  
Quantitative Determination ◽  
Functional State ◽  
Quantitative Estimation ◽  
Succinic Dehydrogenase ◽  
Seminal Vesicles ◽  
The Other ◽  
Succinic Dehydrogenase Activity ◽  
Testosterone Treatment ◽  
Rat Seminal Vesicle

ABSTRACT The seminal vesicles of the rat were stimulated by testosterone-treatment or depressed by castration. The activity of the gland was demonstrated using histoquantitative methods and by quantitative determination of the succinic dehydrogenase activity in the vesicles. There was a good correlation between the seven different variables reflecting the functional state of the vesicle. Quantitative estimation of succinic dehydrogenase of the vesicle seemed to be superior to the other methods because of its greater sensitivity.

scholarly journals Determination of Mitochondrial Functional State in Vital Tissues by Cytobiochemical Analysis of Peripheral Blood Lymphocytes

2013 ◽  
Vol 03 (02) ◽  
pp. 10-13
Author(s):  
Galina A. Frelikh ◽  
Elena A. Yanovskaya ◽  
Natalia Yu. Polomeeva ◽  
Maxim S. Timofeev ◽  
Vladimir A. Slepichev ◽  
...  
Keyword(s):  
Functional State ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes

scholarly journals Protein-synthesizing function and functional state of the liver of dogs at experimental toxocariasis

2020 ◽  
Vol 22 (98) ◽  
pp. 132-137
Author(s):  
W. S. Said ◽  
V. V. Stybel ◽  
B. V. Gutyj ◽  
O. B. Pryima ◽  
I. Y. Mazur
Keyword(s):  
Body Weight ◽  
Functional State ◽  
Total Protein ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Experimental Studies ◽  
Control Group ◽  
Activity Of Enzymes ◽  
Experimental Group

The aim of the study was to investigate the effect of toxocariasis invasion on protein-synthesizing function and functional state of the liver of dogs. For experimental studies, 12 dogs aged from two to four months were used and two groups of six animals were formed in each: control and experimental. Puppies of the experimental group were experimentally infected with the pathogen toxocariasis at a dose of 5,000 invasive eggs of T. canis per kg of body weight. The control puppies were clinically healthy. Protein-synthesizing function of the liver of dogs in experimental toxocariasis was studied by the level of total protein and its fractions. It was found that on the 25th day of the experiment the level of total protein in the blood of the experimental group of dogs was 56.9 ± 1.47 g/l, while in the control group – 63.8 ± 2.92 g/l. The lowest level of the studied indicator was on the 30th day of the experiment in the blood of the experimental group of dogs, where it decreased by 9.6 %. The results of a study of protein fractions in the blood of dogs infested with toxocara showed that the percentage of albumin is likely to decrease. However, in the blood of infected dogs in this period of research there was a probable increase in globulin levels. The study of the effect of toxocariasis invasion on the activity of enzymes in blood serum is a test for the morphological and functional state of tissues and organs. Based on the studies, it was found that with the development of toxocariasis invasion in dogs there is an increase in alanine aminotransferase in their serum. On the 25th and 30th day of the experiment, the activity of the enzyme in the serum of infected dogs was the highest, where compared with the control group of dogs, the activity of ALT increased by 51.2 and 59.1 %, respectively. Similar changes in activity were observed in the determination of aspartate aminotransferase, where, respectively, on the 15th, 20th and 25th day of the experiment, the activity of AST in the serum of infected dogs increased by 19.3, 27.5 and 39.1 %.

scholarly journals The method of alkaline loading and its application in the clinic of internal diseases

2021 ◽  
Vol 27 (8) ◽  
pp. 827-836
Author(s):  
M. S. Solntseva
Keyword(s):  
Gastrointestinal Tract ◽  
Kidney Function ◽  
Functional State ◽  
Acid Content ◽  
Hydrogen Ions ◽  
Animal Organism ◽  
A Value ◽  
Production Of Ammonia ◽  
Ph Fluctuations

The works of recent years have clearly shown the importance that the alkaline-acid balance has in the physiology and pathology of the animal organism. The desire to maintain this balance at a certain height occurs by coordinating the work of a number of organs: the lungs, secreting C02, the liver, taking part in the production of ammonia, the gastrointestinal tract, secerning acid and alkaline secretions and, finally, the kidneys, giving urine with a high acid content and someone's slit, then with less-take part in the regulation of alkalineacid balance. That is why, naturally, the study of the functions of various organs aimed at regulating and maintaining the alkaline-acid balance attracted the attention of clinicians. Rehn and Gnzburg, then Pannewitz, Popescu, Inotesti. Su11a, and finally Rosenberg and Hellfors, studying fluctuations in the concentration of hydrogen ions in urine after loading with alkalis and acids, sought to gain an idea of kidney function aimed at maintaining the gap.- acids. balance, and at the same time apply this method to the study of the functional state of the kidneys in general. However, it turned out to be insufficient to talk about this condition on the basis of determining the Ph of urine. The Ph fluctuations are not always sufficiently prominent, as the review of the data obtained by the authors shows, because the concentration of hydrogen ions is a value depending on the ratio of acid to alkali (voltage 002 and bicarbonate content). This forced us to put forward another method for determining changes in the functions of tissues and kidneys for the introduction of alkali: Mainzer et al., A. G e f t e r emphasized the importance of the determination of bicarbonates in urine and suggested using the method of their determination by gasometric method (according to van Slyke'y), while giving this definition a much greater value than the study of Ph fluctuations alone.

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