Disturbed extensibility and depression of contractility of the myocardium in stress treated with uridine, A cofactor in glycogen resynthesis

1983 ◽  
Vol 96 (5) ◽  
pp. 1501-1504
Author(s):  
F. Z. Meerson ◽  
E. Ya. Vorontsova ◽  
M. G. Pshennikova
Keyword(s):  
Glycogen Resynthesis ◽  
Contractility Of The Myocardium

scholarly journals Phosphorylation-dependent translocation of glycogen synthase to a novel structure during glycogen resynthesis.

2005 ◽  
Vol 280 (42) ◽  
pp. 35784-a
Author(s):  
Clara Prats ◽  
Joan A. Cadefau ◽  
Roser Cussó ◽  
Klaus Qvortrup ◽  
Jakob N. Nielsen ◽  
...  
Keyword(s):  
Glycogen Synthase ◽  
Glycogen Resynthesis ◽  
Novel Structure

scholarly journals Effects of Oral Resveratrol Supplementation on Glycogen Replenishment and Mitochondria Biogenesis in Exercised Human Skeletal Muscle

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3721
Author(s):  
Chun-Ching Huang ◽  
Chia-Chen Liu ◽  
Jung-Piao Tsao ◽  
Chin-Lin Hsu ◽  
I-Shiung Cheng
Keyword(s):  
Skeletal Muscle ◽  
Glucose Uptake ◽  
Muscle Glycogen ◽  
Human Skeletal Muscle ◽  
Young Male ◽  
Gene Expressions ◽  
Plasma Parameters ◽  
Post Exercise ◽  
Glycogen Resynthesis ◽  
Mitochondria Biogenesis

The present study aimed to investigate the effect of oral resveratrol supplementation on the key molecular gene expressions involved in mitochondria biogenesis and glycogen resynthesis in human skeletal muscle. Nine young male athletes participated in the single-blind and crossover designed study. All subjects completed a 4-day resveratrol and placebo supplement in a randomized order while performing a single bout of cycling exercise. Immediately after the exercise challenge, the subjects consumed a carbohydrate (CHO) meal (2 g CHO/Kg body mass) with either resveratrol or placebo capsules. Biopsied muscle samples, blood samples and expired gas samples were obtained at 0 h and 3 h after exercise. The muscle samples were measured for gene transcription factor expression by real-time PCR for glucose uptake and mitochondria biogenesis. Plasma glucose, insulin, glycerol, non-esterified fatty acid concentrations and respiratory exchange ratio were analyzed during post-exercise recovery periods. The results showed that the muscle glycogen concentrations were higher at 3 h than at 0 h; however, there were no difference between resveratrol trial and placebo trial. There were no significantly different concentrations in plasma parameters between the two trials. Similarly, no measured gene expressions were significant between the two trials. The evidence concluded that the 4-day oral resveratrol supplementation did not improve post-exercise muscle glycogen resynthesis and related glucose uptake and mitochondrial biosynthesis gene expression in men.

Muscle glycogen repletion during active postexercise recovery

1987 ◽  
Vol 253 (3) ◽  
pp. E305-E311 ◽  
Author(s):  
E. M. Peters Futre ◽  
T. D. Noakes ◽  
R. I. Raine ◽  
S. E. Terblanche
Keyword(s):  
Blood Lactate ◽  
Muscle Glycogen ◽  
High Intensity ◽  
Active Recovery ◽  
Muscle Lactate ◽  
Glycogen Resynthesis ◽  
Passive Recovery ◽  
Lactate Removal ◽  
Glycogen Repletion ◽  
Lactate Levels

High-intensity intermittent bicycle exercise was used to deplete muscle glycogen levels by 70% and elevate blood lactate levels to greater than 13.0 mmol/l. Thereafter subjects either cycled with one leg for 45 min followed by 45 min of passive recovery (partially active recovery) or rested for 90 min (passive recovery). During the first 45 min of partially active recovery 1) blood lactate (P less than 0.05) and pH levels (P less than 0.05) returned more rapidly to preexercise values than during passive recovery, 2) the rate of net glycogen resynthesis (0.28 mumol . g-1 . min-1) was the same in both legs, and 3) muscle lactate levels were significantly lower (P less than 0.05) in the passive than in the active leg. Thereafter the rate of net muscle glycogen resynthesis was unchanged (0.26 mumol . g-1 . min-1) and lactate removal could theoretically account for only 18% of the glycogen resynthesized. Overall, the rate of muscle glycogen resynthesis and muscle lactate removal was not different from that measured during passive recovery. After high-intensity exercise 1) glycogen repletion is not impeded by light exercise, and 2) blood glucose is an important substrate for glycogen resynthesis.

Post-exercise glycogen resynthesis in trained high-protein or high-fat-fed rats after glucose feeding

1989 ◽  
Vol 58 (6) ◽  
pp. 591-595 ◽  
Author(s):  
P. Satabin ◽  
B. Bois-Joyeux ◽  
M. Chanez ◽  
C. Y. Guezennec ◽  
J. Peret
Keyword(s):  
High Protein ◽  
High Fat ◽  
Post Exercise ◽  
Glycogen Resynthesis ◽  
Glucose Feeding

Glycogen resynthesis in leg muscles of rats during exercise

1984 ◽  
Vol 247 (5) ◽  
pp. R880-R883 ◽  
Author(s):  
S. H. Constable ◽  
J. C. Young ◽  
M. Higuchi ◽  
J. O. Holloszy
Keyword(s):  
Muscle Glycogen ◽  
Prolonged Exercise ◽  
Liver Glycogen ◽  
Treadmill Running ◽  
Moderate Intensity ◽  
Glycogen Depletion ◽  
Moderate Intensity Exercise ◽  
Glycogen Resynthesis ◽  
Leg Muscles ◽  
Insulin In Plasma

This study was undertaken to determine whether glycogen resynthesis can occur in glycogen-depleted muscles in response to glucose feeding during prolonged exercise. Rats were exercised for 40 min with a treadmill running program designed to deplete muscle glycogen. One group was studied immediately after the glycogen-depletion exercise. A second group was given 1 g glucose by stomach tube and exercised for an additional 90 min at a running speed of 22 m/min on a treadmill set at an 8 degree incline; they were given additional 1-g glucose feedings after 30 and 60 min of running. The initial 40-min run resulted in liver glycogen depletion, large decreases in plasma glucose and insulin concentrations, and a marked lowering of muscle glycogen. The glucose feedings resulted in greater than twofold increases in the concentrations of glucose and insulin in plasma, and of glycogen in leg muscles, during the 90 min of running. No repletion of liver glycogen occurred. These results provide evidence that glycogen resynthesis can occur in glycogen-depleted muscle despite continued moderate intensity exercise if sufficient glucose is made available.

scholarly journals Maternal Cardiac Function after Normal Delivery, Preeclampsia, and Eclampsia: A Prospective Study

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Elena Timokhina ◽  
Tatiana Kuzmina ◽  
Alexander Strizhakov ◽  
Elena Pitskhelauri ◽  
Irina Ignatko ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Prospective Study ◽  
Vascular Resistance ◽  
Postpartum Period ◽  
Contractile Function ◽  
Peripheral Resistance ◽  
Normal Delivery ◽  
Uncomplicated Pregnancy ◽  
A Prospective Study ◽  
Contractility Of The Myocardium

Introduction. The aim of this study is to assess maternal cardiac function in the postpartum period, after 2 and 6 months in the parturient with preeclampsia and eclampsia. Materials and Methods. Prospective study: 90 postpartum women after preeclampsia and eclampsia and 55 patients after an uncomplicated pregnancy. The parameters of maternal hemodynamics were recorded on days 1, 3, 5, 9, and 14 of postpartum period, after 2 and 6 months. The cardiac parameters were assessed. Results. PE is accompanied by increased peripheral vascular resistance. The indicator of vascular resistance, SVR, is elevated for both mild and severe PE. With mild PE, a significant increase in SVR is observed up to 5 days of postpartum period, with severe PE/E up to 9 days. We found that in case of severe PE, SVR remains elevated to 6 months after delivery. The parameters of the contractile function of the heart (ESV, EDV, SV, SI, CO, СI, MVCF) were significantly decreased: with mild PE up to 5-9 days, with severe up to 9-14 days of puerperia. ESV, SV, SI, CO, and CI remain low with severe PE up to 6 months. The revealed decreasing of contractile function of the heart is a sign of asymptomatic heart failure. Conclusions. The hemodynamics of the puerperas after PE and E is characterized by impaired contractility of the myocardium and an increase in the indices of peripheral resistance. The degree of deviation in the parameters of cardiac hemodynamics and vascular resistance depended on the severity of hypertensive complications of pregnancy.

The effect of repeated muscle biopsy sampling on ATP and glycogen resynthesis following exercise in man

1996 ◽  
Vol 73 (1-2) ◽  
pp. 186-190 ◽  
Author(s):  
D. Constantin-Teodosiu ◽  
A. Casey ◽  
A. H. Short ◽  
E. Hultman ◽  
P. L. Greenhaff
Keyword(s):  
Muscle Biopsy ◽  
Glycogen Resynthesis

Postexercise protein-carbohydrate and carbohydrate supplements increase muscle glycogen in men and women

1997 ◽  
Vol 83 (6) ◽  
pp. 1877-1883 ◽  
Author(s):  
M. A. Tarnopolsky ◽  
M. Bosman ◽  
J. R. Macdonald ◽  
D. Vandeputte ◽  
J. Martin ◽  
...  
Keyword(s):  
Gender Differences ◽  
Muscle Glycogen ◽  
Endurance Athletes ◽  
Artificial Sweetener ◽  
Dietary Carbohydrate ◽  
Men And Women ◽  
Glycogen Resynthesis ◽  
Habitual Diet ◽  
Fat Supplements ◽  
Sequential Trials

Tarnopolsky, M. A., M. Bosman, J. R. MacDonald, D. Vandeputte, J. Martin, and B. D. Roy. Postexercise protein-carbohydrate and carbohydrate supplements increase muscle glycogen in men and women. J. Appl. Physiol. 83(6): 1877–1883, 1997.—We have previously demonstrated that women did not increase intramuscular glycogen in response to an increased percent of dietary carbohydrate (CHO) (from 60 to 75% of energy intake) (M. A. Tarnopolsky, S. A. Atkinson, S. M. Phillips, and J. D. MacDougall. J. Appl. Physiol. 78: 1360–1368, 1995). CHO and CHO-protein (Pro) supplementation postexercise can potentiate glycogen resynthesis compared with placebo (K. M. Zawadzki, B. B. Yaspelkis, and J. L. Ivy. J. Appl. Physiol. 72: 1854–1859, 1992). We studied the effect of isoenergetic CHO and CHO-Pro-Fat supplements on muscle glycogen resynthesis in the first 4 h after endurance exercise (90 min at 65% peak O2 consumption) in trained endurance athletes (men, n= 8; women, tested in midfollicular phase, n = 8). Each subject completed three sequential trials separated by 3 wk; a supplement was provided immediately and 1-h postexercise: 1) CHO (0.75 g/kg) + Pro (0.1 g/kg) + Fat (0.02 g/kg), 2) CHO (1 g/kg), and 3) placebo (Pl; artificial sweetener). Subjects were given prepackaged, isoenergetic, isonitrogenous diets, individualized to their habitual diet, for the day before and during the exercise trial. During exercise, women oxidized more lipid than did men ( P< 0.05). Both of the supplement trials resulted in greater postexercise glucose and insulin compared with Pl ( P < 0.01), with no gender differences. Similarly, both of these trials resulted in increased glycogen resynthesis (37.2 vs. 24.6 mmol ⋅ kg dry muscle−1 ⋅ h−1, CHO vs. CHO-Pro-Fat, respectively) compared with Pl (7.5 mmol ⋅ kg dry muscle−1 ⋅ h−1; P < 0.001) with no gender differences. We conclude that postexercise CHO and CHO-Pro-Fat nutritional supplements can increase glycogen resynthesis to a greater extent than Pl for both men and women.

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