Effect of artificial hypothermia on reproductive function of male rats

1981 ◽  
Vol 91 (6) ◽  
pp. 799-800
Author(s):  
D. I. Ryzhakov ◽  
A. V. Molodyuk ◽  
S. B. Artifeksov ◽  
A. A. Prokhorova
Keyword(s):  
Reproductive Function ◽  
Male Rats ◽  
Artificial Hypothermia

Effects of paroxitine on biochemical parameters and reproductive function in male rats

2019 ◽  
Author(s):  
Rachid Mosbah ◽  
Aziz Chettoum ◽  
Zohir Djerrou ◽  
Alberto Mantovani
Keyword(s):  
Biochemical Parameters ◽  
Reproductive Function ◽  
Male Rats

scholarly journals Pharmacokinetic and pharmacodynamic studies of the effect of ketoconazole on reproductive function in male rats

1992 ◽  
Vol 15 (5) ◽  
pp. 376-384 ◽  
Author(s):  
J. M. WANG ◽  
X. L. WU ◽  
W. YOU ◽  
L. X. LING ◽  
J. WU ◽  
...  
Keyword(s):  
Reproductive Function ◽  
Male Rats

Experimental Assessment of the Effect of Kagocel on Reproductive Function in Pubertal Male Rats

2017 ◽  
Vol 163 (2) ◽  
pp. 214-217 ◽  
Author(s):  
T. G. Borovskaya ◽  
M. E. Poluektova ◽  
A. V. Vychuzhanina ◽  
V. A. Mashanova ◽  
Yu. A. Shchemerova
Keyword(s):  
Reproductive Function ◽  
Male Rats ◽  
Experimental Assessment

scholarly journals The role of AT1 receptor-mediated reproductive function in renovascular hypertension in male rats

2012 ◽  
Vol 62 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Karin Viana Weissheimer ◽  
Celso Rodrigues Franci ◽  
Aldo Bolten Lucion ◽  
Gilberto Luiz Sanvitto
Keyword(s):  
Renovascular Hypertension ◽  
Reproductive Function ◽  
At1 Receptor ◽  
Male Rats

scholarly journals Reproductive toxicity of triazole fungicides cyproconazole and epoxiconazole when exposed to male and female wistar rats during gametogenesis

2021 ◽  
Vol 54 (1) ◽  
pp. 52-61
Author(s):  
NR Shepelskaya ◽  
YaV Kolyanchuk
Keyword(s):  
Body Weight ◽  
Reproductive Toxicity ◽  
Reproductive Function ◽  
Female Rats ◽  
Male Rats ◽  
Corpora Lutea ◽  
Disruptive Effect ◽  
Male And Female ◽  
Two Samples ◽  
Adverse Effect Level

Aim. Studying the effect of generic pesticides cyproconazole (98 %) and two samples of epoxiconazole (epoxiconazole 1 — 95,75 % and epoxiconazole 2 — 98,7 %) on the reproductive system of male and female Wistar Han rats at the level of the organism when exposed during gametogenesis, identification and characterization of their hazard, as well as assessment of the risk of reproductive toxicity of these compounds. Materials and Methods. The test samples were administered daily (5 days a week) by oral gavage at doses of 0.2 and 2.0 mg/kg for cyproconazole and 0.5 and 2.0 mg/kg for epoxiconazoles during 11 weeks for males, and 10 weeks for females. Also, there were kept intact males and females, intended for crossover mating with experimental animals. After the end of the exposure, functional indicators of the state of the gonads and the ability of animals to reproduce offspring were studied. The duration and the frequency of each stage of the estrous cycle in female rats and the number of motile sperm, the total amount of sperm and the number of abnormal forms of germ cells of the male rats were studied. The reproductive function state in females was evaluated on day 20th of pregnancy. Thereby the number of corpora lutea in the ovaries, number of alive, dead and resorbed foetuses and embryos, the foetus weight, total weight of litters were registered. The studies were carried out in accordance with the recommendations of the Bioethics Commission and the Centre’s standard operating procedures, developed in accordance with the recommendations and requirements of Good Laboratory Practice (GLP). Conclusions. Test substances at a maximum dose of 2.0 mg/kg of body weight have reproductive toxicity and endocrine-disruptive effect, exerting a significant antiandrogenic effect on males and antiestrogenic effect on female rats. No-observed-adverse-effect-level (NOАEL) for gonadal and reproductive toxicity for male and female Wistar Han rats were established. They are 0.2 mg/kg body weight for cyproconazole and 0.5 mg/kg body weight for epoxiconazole. Key Words: azole fungicides, cyproconazole, epoxiconazole, reproductive toxicity, antiandrogenic and antiestrogenic effects, Wistar Han rats.

Effects of Diosgenin on the Reproductive Function of D-galactose-induced Aging Model of Male Rats.

2011 ◽  
Vol 85 (Suppl_1) ◽  
pp. 550-550 ◽  
Author(s):  
Ching-Han Yu ◽  
Kai-Lee Wang ◽  
Ru-Lian Hsu ◽  
Ying-Jui Ho ◽  
Paulus S. Wang
Keyword(s):  
Reproductive Function ◽  
Male Rats ◽  
Aging Model

scholarly journals Developmental Profiles of Neuroendocrine Gene Expression in the Preoptic Area of Male Rats

Endocrinology ◽  
2009 ◽  
Vol 150 (5) ◽  
pp. 2308-2316 ◽  
Author(s):  
Deena M. Walker ◽  
Thomas E. Juenger ◽  
Andrea C. Gore
Keyword(s):  
Molecular Mechanisms ◽  
Preoptic Area ◽  
Reproductive Function ◽  
Gonadal Hormones ◽  
Male Rats ◽  
Low Density ◽  
Sprague Dawley ◽  
Serum Hormones ◽  
Sprague Dawley Rats ◽  
Steroid Sensitive

Reproductive function is controlled by GnRH cells and their steroid-sensitive regulatory inputs. The proper maturation of this system is critical to sexual development and maintenance of adult function. However, the molecular mechanisms underlying these developmental changes, and the potential roles of gonadal hormones in sculpting these processes, have not been fully explored. We performed a developmental profile from postnatal day (P) 1 through P60 of a network of five genes in the preoptic area (POA) that are critical to reproduction in male Sprague Dawley rats. GnRH, estrogen receptors-α, and -β, androgen receptor (AR), and progesterone receptor (PR) mRNAs in the POA were assayed, and serum hormones were measured, in developing male rats. We also used a Taqman low-density array to identify candidate genes that may be important in development. Of the five targeted genes, only AR and PR changed robustly (7- and 3- to 4-fold increases, respectively) during development. All of the gonadal serum hormones changed markedly and with very different patterns from their receptor mRNAs: testosterone decreased from P1 to P30 and then increased to P60; progesterone peaked on P30; and estradiol decreased from P1 to P30. Using the Taqman low-density array, we identified several genes that changed dramatically in the POA with development, particularly G protein-coupled receptor 30, IGF-I, vitamin D receptor, estrogen-related receptor-α, and thyroid receptor-α. Our data demonstrate developmental stage-specific changes in neuroendocrine genes, particularly AR and PR. Moreover, the relationships between hormones and their corresponding receptors undergo dynamic changes across development in male rats.

scholarly journals Dietary supplementation of ginger and turmeric improves reproductive function in hypertensive male rats

2015 ◽  
Vol 2 ◽  
pp. 1357-1366 ◽  
Author(s):  
Ayodele Jacob Akinyemi ◽  
Isaac A. Adedara ◽  
Gustavo Roberto Thome ◽  
Vera Maria Morsch ◽  
Monique Tomazele Rovani ◽  
...  
Keyword(s):  
Reproductive Function ◽  
Dietary Supplementation ◽  
Male Rats
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