Role of oxygen extraction from coronary blood in regulation of the myocardial oxygen supply

1983 ◽  
Vol 95 (1) ◽  
pp. 1-4
Author(s):  
E. B. Novikova ◽  
O. V. Tskitishvili
Keyword(s):  
Oxygen Supply ◽  
Oxygen Extraction ◽  
Myocardial Oxygen Supply

scholarly journals Role of myoglobin in the oxygen supply to red skeletal muscle

1975 ◽  
Vol 250 (23) ◽  
pp. 9038-9043
Author(s):  
BA Wittenberg ◽  
JB Wittenberg ◽  
PR Caldwell
Keyword(s):  
Skeletal Muscle ◽  
Oxygen Supply

910 ESTIMATED MYOCARDIAL OXYGEN SUPPLY TO DEMAND RATIO DURING BILATERAL ARM RESISTANCE EXERCISES AND ARM ERGOMETRY

1994 ◽  
Vol 26 (Supplement) ◽  
pp. S162
Author(s):  
J. L. O??Brien ◽  
A. L. Hicks ◽  
N. McCartney ◽  
D. McConachie ◽  
J. D. MacDougall ◽  
...  
Keyword(s):  
Oxygen Supply ◽  
Arm Ergometry ◽  
Resistance Exercises ◽  
Myocardial Oxygen Supply

scholarly journals Using dual-calibrated functional MRI to map brain oxygen supply and consumption in multiple sclerosis

2021 ◽  
Author(s):  
Hannah L Chandler ◽  
Rachael C Stickland ◽  
Michael Germuska ◽  
Eleonora Patitucci ◽  
Catherine Foster ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Oxygen Consumption ◽  
Healthy Volunteers ◽  
Oxygen Supply ◽  
Oxygen Extraction Fraction ◽  
Oxygen Extraction ◽  
Group Differences ◽  
Lesion Volume ◽  
Brain Physiology ◽  
Significant Difference

Evidence suggests that cerebrovascular function and oxygen consumption are altered in multiple sclerosis (MS). Here, we quantified the vascular and oxygen metabolic MRI burden in patients with MS (PwMS) and assessed the relationship between these MRI measures of and metrics of damage and disability. In PwMS and in matched healthy volunteers, we applied a newly developed dual-calibrated fMRI method of acquisition and analysis to map grey matter (GM) cerebral blood flow (CBF), oxygen extraction fraction (OEF), cerebral metabolic rate of oxygen consumption (CMRO2) and effective oxygen diffusivity of the capillary network (DC). We also quantified physical and cognitive function in PwMS and controls. There was no significant difference in GM volume between 22 PwMS and 20 healthy controls (p=0.302). Significant differences in CBF (PwMS vs. controls: 44.91 +/- 6.10 vs. 48.90 +/- 5.87 ml/100g/min, p=0.010), CMRO2 (117.69 +/- 17.31 vs. 136.49 +/- 14.48 μmol/100g/min p<0.001) and DC (2.70 +/- 0.51 vs. 3.18 +/- 0.41 μmol/100g/mmHg/min, p=0.002) were observed in the PwMS. No significant between-group differences were observed for OEF (PwMS vs. controls: 0.38 +/- 0.09 vs. 0.39 +/- 0.02, p=0.358). Regional analysis showed widespread reductions in CMRO2 and DC for PwMS compared to healthy volunteers. There was a significant correlation between physiological measures and T2 lesion volume, but no association with current clinical disability. Our findings demonstrate concurrent reductions in oxygen supply and consumption in the absence of an alteration in oxygen extraction that may be indicative of a reduced demand for oxygen (O2), an impaired transfer of O2 from capillaries to mitochondria, and/or a reduced ability to utilise O2 that is available at the mitochondria. With no between-group differences in GM volume, our results suggest that changes in brain physiology may precede MRI-detectable GM loss and thus may be one of the pathological drivers of neurodegeneration and disease progression.

Low-temperature CO oxidation over supported Pt, Pd catalysts: Particular role of FeOx support for oxygen supply during reactions

2010 ◽  
Vol 274 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Lequan Liu ◽  
Feng Zhou ◽  
Liguo Wang ◽  
Xiujuan Qi ◽  
Feng Shi ◽  
...  
Keyword(s):  
Low Temperature ◽  
Co Oxidation ◽  
Oxygen Supply ◽  
Pd Catalysts ◽  
Low Temperature Co Oxidation

Noninvasive Assessment of Myocardial Oxygen Supply/Demand

1991 ◽  
Vol 5 (2) ◽  
pp. 110-114
Author(s):  
Giuseppe Ferro ◽  
Letìzia Spinelli ◽  
Carlo Duilio ◽  
Marco Spadafora ◽  
Franco Guarnaccia ◽  
...  
Keyword(s):  
Oxygen Supply ◽  
Noninvasive Assessment ◽  
Myocardial Oxygen Supply

Inhibition of α-adrenergic tone disturbs the distribution of blood flow in the exercising human limb

2013 ◽  
Vol 305 (2) ◽  
pp. H163-H172 ◽  
Author(s):  
Ilkka Heinonen ◽  
Maria Wendelin-Saarenhovi ◽  
Kimmo Kaskinoro ◽  
Juhani Knuuti ◽  
Mika Scheinin ◽  
...  
Keyword(s):  
Blood Flow ◽  
Oxygen Extraction ◽  
Adrenoceptor Antagonist ◽  
Leg Muscles ◽  
Exercise Condition ◽  
Positron Emission ◽  
Adrenoceptor Agonist ◽  
Neuronal Regulation ◽  
Human Limb

The role of neuronal regulation of human cardiovascular function remains incompletely elucidated, especially during exercise. Here we, by positron emission tomography, monitored tissue-specific blood flow (BF) changes in nine healthy young men during femoral arterial infusions of norepinephrine (NE) and phentolamine. At rest, the α-adrenoceptor agonist NE reduced BF by ∼40%, similarly in muscles (from 3.2 ± 1.9 to 1.4 ± 0.3 ml·min−1·100 g−1 in quadriceps femoris muscle), bone (from 1.1 ± 0.4 to 0.5 ± 0.2 ml·min−1·100 g−1) and adipose tissue (AT) (from 1.2 ± 0.7 to 0.7 ± 0.3 ml·min−1·100 g−1). During exercise, NE reduced exercising muscle BF by ∼16%. BF in AT was reduced similarly as rest. The α-adrenoceptor antagonist phentolamine increased BF similarly in the different muscles and other tissues of the limb at rest. During exercise, BF in inactive muscle was increased 3.4-fold by phentolamine compared with exercise without drug, but BF in exercising muscles was not influenced. Bone and AT ( P = 0.055) BF were also increased by phentolamine in the exercise condition. NE increased and phentolamine decreased oxygen extraction in the limb during exercise. We conclude that inhibition of α-adrenergic tone markedly disturbs the distribution of BF and oxygen extraction in the exercising human limb by increasing BF especially around inactive muscle fibers. Moreover, although marked functional sympatholysis also occurs during exercise, the arterial NE infusion that mimics the exaggerated sympathetic nerve activity commonly seen in patients with cardiovascular disease was still capable of directly limiting BF in the exercising leg muscles.

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