Reactive properties of mesangial cells of the renal glomerulus during extremal loading of the kidney

1984 ◽  
Vol 97 (1) ◽  
pp. 120-123
Author(s):  
B. V. Shutka ◽  
E. P. Mel'man ◽  
L. E. Koval'chuk
Keyword(s):  
Mesangial Cells ◽  
Renal Glomerulus ◽  
Reactive Properties

A re-evaluation of the mesangial cells of the renal glomerulus

1968 ◽  
Vol 86 (3) ◽  
pp. 364-383 ◽  
Author(s):  
Luciano Zamboni ◽  
Cesare Martino
Keyword(s):  
Mesangial Cells ◽  
Renal Glomerulus

SIRP-α-CD47 system functions as an intercellular signal in the renal glomerulus

2010 ◽  
Vol 299 (3) ◽  
pp. F517-F527 ◽  
Author(s):  
Hidetake Kurihara ◽  
Yutaka Harita ◽  
Koichiro Ichimura ◽  
Seisuke Hattori ◽  
Tatsuo Sakai
Keyword(s):  
Plasma Membrane ◽  
Tyrosine Phosphorylation ◽  
Mesangial Cells ◽  
Regulatory Protein ◽  
Cell Communication ◽  
Slit Diaphragm ◽  
Type I ◽  
Intercellular Signaling ◽  
Renal Glomerulus ◽  
Extracellular Region

The renal glomerulus consists of endothelial cells, podocytes, and mesangial cells. These cells cooperate with each other for glomerular filtration; however, the intercellular signaling molecules between glomerular cells are not fully determined. Tyrosine phosphorylation of slit diaphragm molecules is a key to the detection of the signal to podocytes from other cells. Although src kinase is involved in this event, the molecules working for dephosphorylation remain unclear. We demonstrate that signal-inhibitory regulatory protein (SIRP)-α, which recruits a broadly distributed tyrosine dephosphorylase SHP-2 to the plasma membrane, is located in podocytes. SIRP-α is a type I transmembrane glycoprotein, which has three immunoglobulin-like domains in the extracellular region and two SH2 binding motifs in the cytoplasm. This molecule functions as a scaffold for many proteins, especially the SHP-2 molecule. SIRP-α is concentrated in the slit diaphragm region of normal podocytes. CD47, a ligand for SIRP-α, is also expressed in the glomerulus. CD47 is located along the plasma membrane of mesangial cells, but not on podocytes. CD47 is markedly decreased during mesangiolysis, but increased in mesangial cells in the restoration stage. SIRP-α is heavily tyrosine phosphorylated under normal conditions; however, tyrosine phosphorylation of SIRP-α was markedly decreased during mesangiolysis induced by Thy1.1 monoclonal antibody injection. It is known that the cytoplasmic domain of SIPR-α is dephosphorylated when CD47 binds to the extracellular domain of SIRP-α. The data suggest that the CD47-SIRP-α interaction may be functionally important in cell-cell communication in the diseased glomerulus.

Mesangial Cells Orchestrate Inflammation in the Renal Glomerulus

Physiology ◽  
1994 ◽  
Vol 9 (6) ◽  
pp. 271-276 ◽  
Author(s):  
J Pfeilschifter
Keyword(s):  
Cell Proliferation ◽  
Mesangial Cell ◽  
Mesangial Cells ◽  
Renal Glomerulus ◽  
Mesangial Cell Proliferation ◽  
Inflammatory Processes ◽  
Matrix Production

The mesangium is a highly specialized pericapillary tissue that is involved in most pathological processes of the renal glomerulus. Mesangial cells orchestrate inflammatory processes in the renal glomerulus by increased mediator production, increased matrix production, and increased mesangial cell proliferation.

A Scanning Electron Microscopic Study of the Uriniferous Tubules

1973 ◽  
Vol 31 ◽  
pp. 622-623
Author(s):  
Peter M. Andrews
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Renal Glomerulus ◽  
Electron Microscopic ◽  
Vascular Perfusion ◽  
Scanning Electron Microscopic Study ◽  
Scanning Electron Microscopic ◽  
Collecting Tubules ◽  
Bowman's Capsule ◽  
Scanning Electron

Although there have been a number of recent scanning electron microscopic reports on the renal glomerulus, the advantages of scanning electron microscopy have not yet been applied to a systematic study of the uriniferous tubules. In the present investigation, scanning electron microscopy was used to study the ultrastructural morphology of the proximal, distal, thin loop, and collecting tubules. Material for observation was taken from rat kidneys which were fixed by vascular perfusion, sectioned by either cutting or fracturing technigues, and critically point dried.The brush border characterising proximal tubules is first detected on the luminal surface of Bowman's capsule adjacent to the urinary pole orifice. In this region one frequently finds irregular microvilli characterized by broad and flattened bases with occasional bulbous structures protruding from their surfaces.

505-P: ROCK2 Regulates TGF-Beta-Induced Expression of CTGF and Profibrotic Genes via NF-kappa B and Cytoskeleton Dynamics in the Mesangial Cells

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 505-P ◽  
Author(s):  
YOSUKE NAGAI ◽  
DAIJI KAWANAMI ◽  
KEIICHIRO MATOBA ◽  
YUSUKE TAKEDA ◽  
KAZUNORI UTSUNOMIYA
Keyword(s):  
Mesangial Cells ◽  
Tgf Beta ◽  
Nf Kappa B ◽  
Induced Expression ◽  
Cytoskeleton Dynamics

Identification and characterization of aldose reductase in cultured rat mesangial cells

Diabetes ◽  
1992 ◽  
Vol 41 (9) ◽  
pp. 1165-1171 ◽  
Author(s):  
R. Kikkawa ◽  
K. Umemura ◽  
M. Haneda ◽  
N. Kajiwara ◽  
S. Maeda ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Mesangial Cells ◽  
Identification And Characterization
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