Role of the locus coeruleus in development of cerebrovascular disturbances in acute myocardial ischemia

1984 ◽  
Vol 97 (4) ◽  
pp. 399-401
Author(s):  
L. G. Miller ◽  
Yu. I. Pivovarov ◽  
G. N. Kryzhanovskii
Keyword(s):  
Myocardial Ischemia ◽  
Locus Coeruleus ◽  
Acute Myocardial Ischemia

scholarly journals The Efficacy of Antiarrhythmic Agents During Acute Myocardial Ischemia and the Role of Heart Rate

Circulation ◽  
1974 ◽  
Vol 50 (3) ◽  
pp. 507-514 ◽  
Author(s):  
RONALD R. HOPE ◽  
DAVID O. WILLIAMS ◽  
NABIL EL-SHERIF ◽  
RALPH LAZZARA ◽  
BENJAMIN J. SCHERLAG
Keyword(s):  
Heart Rate ◽  
Myocardial Ischemia ◽  
Acute Myocardial Ischemia ◽  
Antiarrhythmic Agents

scholarly journals Electroacupuncture Ameliorates Acute Myocardial Ischemia: A Potential Role of the Locus Coeruleus

2020 ◽  
Vol 2020 ◽  
pp. 1-12 ◽  
Author(s):  
Xin Wu ◽  
Kun Wang ◽  
Shuai Cui ◽  
Shengbing Wu ◽  
Guoqi Zhu ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Cardiac Function ◽  
Locus Coeruleus ◽  
Serum Levels ◽  
Acute Myocardial Ischemia ◽  
Inflammatory Factors ◽  
Neuron Activity ◽  
Myocardial Tissue ◽  
Hs Crp

The locus coeruleus (LC) is closely linked with cardiovascular disease. However, whether it mediates the alleviating effect of electroacupuncture (EA) on acute myocardial ischemia (AMI) remains unclear. A rat model of myocardial ischemia was established through occlusion of the left anterior descending coronary artery. Multichannel in vivo recording and other techniques were used to assess neurons in the LC, norepinephrine (NE) and dopamine (DA) levels in central and myocardial tissue, serum levels of inflammatory factors, and cardiac function. After induction of AMI, LC neuron activity increased and the central NE concentrations increased, while those of DA decreased. Moreover, the serum levels of high-sensitivity C-reactive protein (hs-CRP) increased, whereas those of interleukin-10 (IL-10) decreased. However, these effects were reversed by EA. Additionally, LC lesioning affected NE and DA levels in myocardial tissue and weakened the antimyocardial ischemic effect of EA. Collectively, our results indicated that LC is closely related to AMI and plays an important role in the antimyocardial ischemic effect of EA. This mechanism may be related to inhibition of LC neuron activity by EA, which inhibits the release of large amounts of hs-CRP and promotes that of IL-10 in the serum. Besides, after LC lesioning, EA may improve cardiac function by inhibiting the release of large amounts of NE and promoting the release of DA in myocardial tissue.

Critical Role of Dose in Protection by Propranolol Against Ventricular Fibrillation in a Pig Model of Acute Myocardial Ischemia

1989 ◽  
Vol 13 (2) ◽  
pp. 192-197 ◽  
Author(s):  
Cecilia A. Muller ◽  
Lionel H. Opie ◽  
Max Peisach ◽  
Carlos A. Pineda ◽  
Christian W. Hamm ◽  
...  
Keyword(s):  
Ventricular Fibrillation ◽  
Myocardial Ischemia ◽  
Critical Role ◽  
Acute Myocardial Ischemia ◽  
Pig Model
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