A new synthesis of thes-triazolo[1,5-a]pyridine ring system

1995 ◽  
Vol 126 (11) ◽  
pp. 1213-1215 ◽  
Author(s):  
G. Haj�s ◽  
G. Tim�ri ◽  
A. Messmer ◽  
A. Zagyva ◽  
I. Miskolczi ◽  
...  
ChemInform ◽  
2010 ◽  
Vol 27 (10) ◽  
pp. no-no
Author(s):  
G. HAJOS ◽  
G. TIMARI ◽  
A. MESSMER ◽  
A. ZAGYVA ◽  
I. MISKOLCZI ◽  
...  

2019 ◽  
Vol 16 (12) ◽  
pp. 931-934 ◽  
Author(s):  
Alexandra Kamlah ◽  
Franz Bracher

: A new synthesis of the 2,6-naphthyridine alkaloid 4-methyl-2,6-naphthyridine from Antirrhinum majus has been developed. Key steps are a regioselective oxidation of 3-bromo-4,5- dimethylpyridine to the corresponding 4-formyl derivative, and the annulation of the second pyridine ring by Suzuki-Miyaura cross-coupling using (E)-2-ethoxyvinylboronic acid pinacol ester as a masked acetaldehyde equivalent. This protocol gives the alkaloid in four steps starting from commercially available 3,4-dimethylpyridine in 15% overall yield. This annulation protocol should be useful for the synthesis of other condensed pyridines as well.


2000 ◽  
Vol 41 (52) ◽  
pp. 10251-10255 ◽  
Author(s):  
Masashi Ohba ◽  
Rie Izuta ◽  
Emi Shimizu
Keyword(s):  

1943 ◽  
Vol 65 (8) ◽  
pp. 1502-1503 ◽  
Author(s):  
C. F. H. Allen ◽  
J. W. Gates
Keyword(s):  

ChemInform ◽  
2010 ◽  
Vol 32 (36) ◽  
pp. no-no
Author(s):  
Lalgudi S. Harikrishnan ◽  
Terri L. Boehm ◽  
H. D. Hollis Showalter

2018 ◽  
Vol 54 (100) ◽  
pp. 14128-14131 ◽  
Author(s):  
Tao Jin ◽  
Hongdong Yuan ◽  
Shikuan Su ◽  
Xueshun Jia ◽  
Chunju Li ◽  
...  

A DABCO-catalyzed annulation reaction of pyridin-2-amine and substituted allenoates enables the ring-opening of a pyridine ring system and the formation of two new rings including a pyrimidinone ring and a benzene ring.


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