Operational amplifier with diode-resistor networks in the negative feedback circuit

1978 ◽  
Vol 21 (2) ◽  
pp. 262-264
Author(s):  
A. A. Stolyarov
Keyword(s):  
Negative Feedback ◽  
Operational Amplifier ◽  
Feedback Circuit ◽  
Resistor Networks ◽  
Negative Feedback Circuit

scholarly journals Highly Sensitive Whole-Cell Biosensor for Cadmium Detection Based on a Negative Feedback Circuit

2021 ◽  
Vol 9 ◽  
Author(s):  
Guangbao Zhang ◽  
Shuting Hu ◽  
Xiaoqiang Jia
Keyword(s):  
Sensitivity And Specificity ◽  
Negative Feedback ◽  
Output Signal ◽  
World Health ◽  
Real Field ◽  
Feedback Circuit ◽  
Whole Cell ◽  
Feedback Amplifier ◽  
Cadmium Detection ◽  
Negative Feedback Circuit

Although many whole-cell biosensors (WCBs) for the detection of Cd2+ have been developed over the years, most lack sensitivity and specificity. In this paper, we developed a Cd2+ WCB with a negative feedback amplifier in P. putida KT2440. Based on the slope of the linear detection curve as a measure of sensitivity, WCB with negative feedback amplifier greatly increased the output signal of the reporter mCherry, resulting in 33% greater sensitivity than in an equivalent WCB without the negative feedback circuit. Moreover, WCB with negative feedback amplifier exhibited increased Cd2+ tolerance and a lower detection limit of 0.1 nM, a remarkable 400-fold improvement compared to the WCB without the negative feedback circuit, which is significantly below the World Health Organization standard of 27 nM (0.003 mg/L) for cadmium in drinking water. Due to the superior amplification of the output signal, WCB with negative feedback amplifier can provide a detectable signal in a much shorter time, and a fast response is highly preferable for real field applications. In addition, the WCB with negative feedback amplifier showed an unusually high specificity for Cd2+ compared to other metal ions, giving signals with other metals that were between 17.6 and 41.4 times weaker than with Cd2+. In summary, the negative feedback amplifier WCB designed in this work meets the requirements of Cd2+ detection with very high sensitivity and specificity, which also demonstrates that genetic negative feedback amplifiers are excellent tools for improving the performance of WCBs.

scholarly journals Modeling PLL Loop with Nonlinearity

Telecom IT ◽  
2019 ◽  
Vol 7 (4) ◽  
pp. 9-14
Author(s):  
Y. Nikitin ◽  
G. Tsygankov
Keyword(s):  
Nonlinear Model ◽  
Negative Feedback ◽  
Phase Locked Loop ◽  
Phase Detector ◽  
Stationary Mode ◽  
Voltage Controlled Oscillator ◽  
Feedback Circuit ◽  
Pulse Counter ◽  
Pulse Phase ◽  
Negative Feedback Circuit

A model of a pulse phase-locked loop multiplying ring in a MicroCap11 medium is considered. The analysis uses a nonlinear model of a voltage-controlled oscillator with a user-defined control characteristic. An RS-trigger is used as a pulse-phase detector, a pulse counter in the negative feedback circuit is implemented on JK-triggers. Transient processes in the ring, as well as the spectrum of the output oscillations in the steady (stationary) mode are considered.

scholarly journals Negative feedback circuit for toll like receptor-8 activation in human embryonic Kidney 293 using outer membrane vesicle delivered bi-specific siRNA

2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Anurag Adhikari ◽  
Birendra Prasad Gupta ◽  
Krishna Das Manandhar ◽  
Shravan Kumar Mishra ◽  
Hari Krishna Saiju ◽  
...  
Keyword(s):  
Outer Membrane ◽  
Negative Feedback ◽  
Membrane Vesicle ◽  
Outer Membrane Vesicle ◽  
Feedback Circuit ◽  
Toll Like Receptor ◽  
Human Embryonic Kidney ◽  
Negative Feedback Circuit
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