Measurements of the three-dimensional energy characteristics of laser radiation in the IR region of the spectrum

1978 ◽  
Vol 21 (5) ◽  
pp. 623-627
Author(s):  
P. A. Morozov ◽  
G. I. Rukman
Keyword(s):  
Laser Radiation ◽  
Three Dimensional ◽  
Energy Characteristics

scholarly journals Generalized predictive model of estimation of inhibition of muscarinic receptors M1-M5

2020 ◽  
Vol 3 (3) ◽  
pp. e00129
Author(s):  
A.V. Mikurova ◽  
V.S. Skvortsov ◽  
V.V. Grigoryev
Keyword(s):  
Predictive Model ◽  
Muscarinic Receptors ◽  
Three Dimensional ◽  
Dynamics Simulation ◽  
Dimensional Structure ◽  
Regression Equations ◽  
Energy Characteristics ◽  
Value Prediction ◽  
M3 Receptor ◽  
The Mean

A general predictive model for assessing the inhibition constant (K<sub>i</sub>) value of human acetylcholine muscarinic receptors M1-M5 by potential ligands has been constructed. We used information on the three-dimensional structure of human M1, M2, M4, and M5 receptors, as well as a model of the M3 receptor constructed according to homology based on the structure of the rat M3 receptor. A set of complexes of known inhibitors with the target receptor constructed by means of molecular docking, was selected using an additional option: the coincidence of the spatial position of 4 pharmacophore points of a tested inhibitor and tiotropium, for which the position in the crystal structure was known. For five types of M receptors 199 complexes with known K<sub>i</sub> values were selected. Based on the data obtained during molecular dynamics simulation of these complexes by means of the MM-PBSA/MM-GBSA methods, their energy characteristics were calculated. They were used as independent variables in linear regression equations for pK<sub>i</sub> value prediction. The R<sup>2</sup> prediction for the generalized equation was 0.7, and the mean prediction error was 0.55 logarithmic units with a range for pK<sub>i</sub>=4.7.

scholarly journals Fabrication of 3D microchannels for tissue engineering in photosensitive glass using NIR femtosecond laser radiation

2019 ◽  
Vol 5 (1) ◽  
pp. 34-45 ◽  
Author(s):  
Ulrike Brokmann ◽  
Tobias Milde ◽  
Edda Rädlein ◽  
Klaus Liefeith
Keyword(s):  
Tissue Engineering ◽  
Laser Radiation ◽  
Femtosecond Laser ◽  
Raw Materials ◽  
Glass Structure ◽  
Three Dimensional ◽  
Silver Ions ◽  
Laser Exposure ◽  
Femtosecond Laser Radiation ◽  
Rate Ratios

Abstract The biocompatibility of photosensitive glasses allows various biomedical applications; one is the field of tissue engineering and more precisely microengineered tissue-on-a-chip platforms to study the tissue microenvironment and disease modelling. Three dimensional architectures of adapted components are required for modern materials. A photosensitive lithiumalumosilicate glass FS21 was investigated regarding the interaction with a Ti:Sapphire laser systemto build three dimensional buried channels inside the glass. Femtosecond laser radiation with a wavelength of 800 nm and pulse duration of 140 fs was used to modify the glass structure. Subsurface channel geometries were achieved by a subsequent thermal treatment and were formed into capillaries using wet chemical etching of the exposed and crystallised channels. Contrary to ultraviolet (UV) exposure, spectral optical investigations showed that fs laser exposure caused various radiation induced defects in the base glass coupled with the generation of photoelectrons for the photochemical modification of silver ions. We observed an outgassing of different species coming from raw materials of the original glass batch during the glass crystallisation process. Etch rate ratios differ between 1:25 and 1:45 and are dependent on: stoichiometric deviation between surface and bulk, crystal size and distribution and exchange of the etching agent in narrow capillaries.

Computer Simulation of the Three-Dimensional Regime of Proton Acceleration in the Interaction of Laser Radiation with a Thin Spherical Target

2001 ◽  
Vol 27 (5) ◽  
pp. 363-371 ◽  
Author(s):  
H. Ruhl ◽  
S. V. Bulanov ◽  
T. E. Cowan ◽  
T. V. Liseĭkina ◽  
P. Nickles ◽  
...  
Keyword(s):  
Computer Simulation ◽  
Laser Radiation ◽  
Three Dimensional ◽  
Proton Acceleration ◽  
Spherical Target

scholarly journals Three-Dimensional Micro- and Nano-Structuring of Materials by Tightly Focused Laser Radiation

2008 ◽  
Vol 81 (4) ◽  
pp. 411-448 ◽  
Author(s):  
Saulius Juodkazis ◽  
Vygantas Mizeikis ◽  
Shigeki Matsuo ◽  
Kosei Ueno ◽  
Hiroaki Misawa
Keyword(s):  
Laser Radiation ◽  
Three Dimensional

scholarly journals THREE-DIMENSIONAL MODEL OF QUANTUM DOTS' SELF-ASSEMBLY UNDER THE ACTION OF LASER RADIATION

2017 ◽  
Vol 41 (4) ◽  
pp. 577-580 ◽  
Author(s):  
V. A. Tkachenko ◽  
A. S. Tsipotan ◽  
A. S. Aleksandrovsky ◽  
V. V. Slabko
Keyword(s):  
Quantum Dots ◽  
Laser Radiation ◽  
Self Assembly ◽  
Three Dimensional ◽  
Dimensional Model ◽  
Three Dimensional Model

Features of the Polymethyl Methacrylate Destruction Process by Various Types of Dynamic Loading

2021 ◽  
Vol 899 ◽  
pp. 473-478
Author(s):  
B.I. Kunizhev ◽  
A.M. Kugotova ◽  
Z.S. Torshhoeva ◽  
Ruslan A. Shetov
Keyword(s):  
Comparative Analysis ◽  
Laser Radiation ◽  
Polymethyl Methacrylate ◽  
Dynamic Loading ◽  
High Speed ◽  
Laser Action ◽  
Initial Energy ◽  
Destruction Process ◽  
Energy Characteristics ◽  
Similarities And Differences

The paper presents a comparative analysis of the dynamic loading of a polymethyl methacrylate (PMMA) target by a polyethylene (PE) projectile exposed to laser radiation with similar initial energy characteristics of the projectile and the laser pulse. The similarities and differences in the mechanisms of the target's response and its destruction to high-speed mechanical and laser action are shown. A higher efficiency of laser irradiation in the destruction of PMMA was found, and the conditions for the transition of the fracture mechanism from brittle to elastic-plastic were shown.

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