Changes in folic acid metabolism during administration of vitamin B12 antimetabolites and thyroid hormones

1968 ◽  
Vol 65 (1) ◽  
pp. 59-61
Author(s):  
Z. N. Dzhelieva ◽  
G. M. Kyul'yan ◽  
A. V. Trufanov
Keyword(s):  
Folic Acid ◽  
Thyroid Hormones ◽  
Vitamin B12 ◽  
Acid Metabolism ◽  
Folic Acid Metabolism

scholarly journals Folic acid metabolism in vitamin B12-deficient sheep. Effects of injected methionine on liver constituents associated with folate metabolism

1974 ◽  
Vol 142 (1) ◽  
pp. 105-117 ◽  
Author(s):  
Richard M. Smith ◽  
William S. Osborne-White ◽  
Jeffrey M. Gawthorne
Keyword(s):  
Folic Acid ◽  
Ion Exchange ◽  
Vitamin B12 ◽  
Lactobacillus Casei ◽  
Acid Metabolism ◽  
Major Effect ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Folate Metabolism ◽  
Folic Acid Metabolism

1. The effects of injected l-methionine (2g every second day for 28 days) on liver folates and other constituents of liver associated with folate metabolism were studied in vitamin B12-deficient ewes and their pair-fed controls receiving vitamin B12. The dose rate of methionine used was sufficient to restore almost to normal the elevated excretion in the urine of formiminoglutamate in the deficient animals. 2. Liver folates active for Lactobacillus casei, Streptococcus faecalis R and Pediococcus cerevisiae were severely depressed in deficient livers and were partly restored by methionine. Analysis of the folates after ion-exchange chromatography showed that the major effect of methionine was to increase the concentrations of tetrahydrofolates and formyltetrahydrofolates. Methyltetrahydrofolates were also increased, but there was no effect of methionine on the small amounts of incompletely reduced folates present in deficient livers. The folates present were predominantly penta-, hexa- and hepta-glutamates whether or not animals received vitamin B12 or methionine. 3. Concentrations of ATP, NAD+, NADH and NADPH were lower in freeze-clamped liver from vitamin B12-deficient sheep than in liver from pair-fed, vitamin B12-treated sheep. These changes were not affected by methionine which was also without effect on the elevated K+/Na+ ratios found in deficient livers. 4. The livers of vitamin B12-deficient animals contained lower concentrations of choline and higher concentrations of lipid than their pair-fed controls. These effects were reversed by methionine.

Folic Acid Metabolism

1959 ◽  
Vol 7 (3) ◽  
pp. 302-310
Author(s):  
A. V. TRUFANOV
Keyword(s):  
Folic Acid ◽  
Acid Metabolism ◽  
Folic Acid Metabolism

A genetic deficiency in folic acid metabolism impairs recovery after ischemic stroke

2018 ◽  
Vol 309 ◽  
pp. 14-22 ◽  
Author(s):  
Nafisa M. Jadavji ◽  
Joshua T. Emmerson ◽  
Ushananthini Shanmugalingam ◽  
Amanda J. MacFarlane ◽  
William G. Willmore ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Folic Acid ◽  
Acid Metabolism ◽  
Folic Acid Metabolism ◽  
Genetic Deficiency
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