Relationship between the level of serum L-tryptophan and its hepatic uptake and metabolism in rats with carbon tetrachloride-induced liver cirrhosis

Amino Acids ◽  
1996 ◽  
Vol 10 (4) ◽  
pp. 369-378 ◽  
Author(s):  
Y. Ohta ◽  
M. Uemura ◽  
K. Saito ◽  
E. Sasaki ◽  
I. Ishiguro
Keyword(s):  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Hepatic Uptake ◽  
Uptake And Metabolism

LIVER CIRRHOSIS AND OESTROGEN METABOLISM – PERFUSION STUDIES WITH CIRRHOTIC RAT LIVERS

1979 ◽  
Vol 90 (4) ◽  
pp. 658-668
Author(s):  
Michael Höller ◽  
Karin Dengler ◽  
Renate Fabricius ◽  
Heinz Breuer
Keyword(s):  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Enterohepatic Circulation ◽  
Hepatic Uptake ◽  
Distribution Volume ◽  
List Type ◽  
Combined Application ◽  
Perfusion Studies ◽  
Rat Livers

ABSTRACT Radioactive oestrone and oestradiol-17β were perfused through normal and cirrhotic livers of rats. Liver cirrhosis had been induced by a combined application of carbon tetrachloride and azathioprine. The hepatic uptake of both oestrogens by cirrhotic livers was reduced; the uptake of oestrone was more affected than that of oestradiol-17β, The pattern of oestrogen metabolites indicated a reduction of the sulphotransferase activity in cirrhotic livers. The activity of other enzymes of oestrogen metabolism were similar in normal and cirrhotic livers. The amount of oestrogen glucuronides excreted into the bile was significantly less in cirrhotic livers although the bile volume was larger in cirrhotic than in normal livers. The release of oestrogen metabolites into the circulating medium was considerably higher during perfusion of cirrhotic livers. From the findings presented here it is concluded that the turnover of oestrogens is slower in cirrhotic than in normal livers. Moreover, it may be speculated that the distribution volume of the oestrogen metabolites is smaller in rats with liver cirrhosis, due to a disturbed enterohepatic circulation. This results in higher oestrogen concentrations in extracellular fluids, thus supporting the concept of hyper-oestrogenism in liver cirrhosis.

Hepatic uptake of intact glutathione S-conjugate, inhibition by organic anions, and sinusoidal catabolism

1993 ◽  
Vol 265 (3) ◽  
pp. G547-G554
Author(s):  
C. A. Hinchman ◽  
A. T. Truong ◽  
N. Ballatori
Keyword(s):  
Guinea Pig ◽  
Rat Liver ◽  
Marked Decrease ◽  
Hepatic Uptake ◽  
Half Time ◽  
High Concentrations ◽  
Rat Livers ◽  
Dose Dependent ◽  
Uptake And Metabolism ◽  
Guinea Pig Liver

To identify potential mechanisms for hepatic removal of circulating glutathione (GSH) conjugates, uptake and metabolism of S-2,4-dinitrophenylglutathione (DNP-SG) were examined in isolated perfused livers from rat and guinea pig. Guinea pig livers perfused with 5 mumol of DNP-SG in a recirculating system (50 microM initial concn) rapidly cleared the conjugate from the perfusate (half time 3.7 min), whereas clearance was considerably slower in rat liver (half time 35 min). Disappearance of DNP-SG from the perfusate was accompanied by a simultaneous appearance of DNP-SG and its metabolites in bile. Addition of acivicin, an inhibitor of gamma-glutamyltransferase (gamma-GT), to the perfusate resulted in a marked decrease in DNP-SG clearance by guinea pig liver but had no effect in rat liver, suggesting that in the guinea pig this process is largely dependent on sinusoidal gamma-GT activity. However, even in the presence of acivicin, rat and guinea pig livers removed nearly one-half of the administered DNP-SG from the recirculating perfusate over 30 min. High concentrations of DNP-SG were found in bile (up to 3.7 mM), indicating that the liver is capable of transporting the intact conjugate from the circulation. When rat livers were perfused with higher concentrations of DNP-SG (100 and 250 microM), biliary excretion of DNP-SG increased dose dependently, with concentrations in bile reaching 10 mM at the higher dose. This was accompanied by a dose-dependent choleresis.(ABSTRACT TRUNCATED AT 250 WORDS)

EFFECTS OF NATURAL AND RECOMBINANT INTERFERON ON CARBON TETRACHLORIDE- INDUCED LIVER CIRRHOSIS

2001 ◽  
Vol 10 (2) ◽  
pp. 11-17
Author(s):  
Mohamed Hassan ◽  
Mona El-Azab ◽  
EI-Sayed El-Awady ◽  
Soad Abou-El-Ela
Keyword(s):  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Recombinant Interferon

Pharmacodynamic Changes of Mivacurium in Liver Cirrhosis Model in Rabbits Using Carbon Tetrachloride Intoxication

2004 ◽  
Vol 46 (6) ◽  
pp. 708
Author(s):  
Young Duk Cha ◽  
Hong Sik Lee ◽  
Hwa Young Ki ◽  
Hye Jin Park ◽  
Chun Woo Yang ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Carbon Tetrachloride Intoxication

Nanoparticle Based Delivery of Quercetin for the Treatment of Carbon Tetrachloride Mediated Liver Cirrhosis in Rats

2016 ◽  
Vol 12 (2) ◽  
pp. 274-285 ◽  
Author(s):  
Shashi Kant Verma ◽  
Shweta Rastogi ◽  
Indu Arora ◽  
Kalim Javed ◽  
Mohd Akhtar ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Carbon Tetrachloride

scholarly journals Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection

2012 ◽  
Vol 27 (8) ◽  
pp. 589-594 ◽  
Author(s):  
Thamirys Guimarães Marques ◽  
Eleazar Chaib ◽  
Juliana Hamati da Fonseca ◽  
Ana Cecília Rodrigues Lourenço ◽  
Felipe Duarte Silva ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Bile Duct ◽  
Web Sites ◽  
Bile Duct Ligation ◽  
Experimental Models ◽  
Duct Ligation ◽  
Experimental Liver Cirrhosis ◽  
Experimental Liver ◽  
Better Than

PURPOSE: To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis. METHODS: This research was made through Medline/PubMed and SciELO web sites looking for papers on the content "induction of liver cirrhosis in rats". We have found 107 articles but only 30 were selected from 2004 to 2011. RESULTS: The most common methods used for inducing liver cirrhosis in the rat were administration of carbon tetrachloride (CCl4) and bile duct ligation (BDL). CCl4 has induced cirrhosis from 36 hours to 18 weeks after injection and BDL from seven days to four weeks after surgery. CONCLUSION: For a safer inducing cirrhosis method BDL is better than CCl4 because of the absence of toxicity for researches and shorter time for achieving it.

scholarly journals Oral Supplementation with Branched-Chain Amino Acids Improves Transthyretin Turnover in Rats with Carbon Tetrachloride-Induced Liver Cirrhosis

1996 ◽  
Vol 126 (5) ◽  
pp. 1412-1420 ◽  
Author(s):  
Toshio Usui ◽  
Hisataka Moriwaki ◽  
Hiroo Hatakeyama ◽  
Tetsuhiro Kasai ◽  
Masahiko Kato ◽  
...  
Keyword(s):  
Amino Acids ◽  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Branched Chain Amino Acids ◽  
Oral Supplementation ◽  
Branched Chain
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