Content of catecholamines in the brain stem of albino rats during development of tolerance to trifluoperazine

1970 ◽  
Vol 70 (2) ◽  
pp. 896-898
Author(s):  
A. V. Val'dman ◽  
M. N. Lebedeva
Keyword(s):  
Brain Stem ◽  
Albino Rats ◽  
The Brain ◽  
Development Of Tolerance

scholarly journals The features of blood supply to the rat medulla during pathological periodic apneustic respiration provoked by sodium hydroxybutyrate

2018 ◽  
pp. 119-123
Author(s):  
Л.Н. Тихомирова ◽  
Д.Д. Мациевский ◽  
С.В. Ревенко ◽  
И.А. Тараканов
Keyword(s):  
Brain Stem ◽  
Blood Supply ◽  
Nervous Tissue ◽  
Sodium Hydroxybutyrate ◽  
Albino Rats ◽  
Venous Outflow ◽  
Periodic Oscillations ◽  
Chest Cavity ◽  
Respiration Rhythm ◽  
The Brain

В острых опытах на наркотизированных самцах беспородных белых крыс изучали кровоснабжение ствола головного мозга в зоне дыхательного центра при моделировании периодического апнейстического дыхания с помощью оксибутирата натрия. При формировании периодического патологического дыхания в микрососудах ствола мозга возникают характерные периодические колебания кровотока и оксигенации нервной ткани, которые соответствуют дыхательным движениям. Кроме того, в этих условиях увеличивается кровенаполнение и величина венозного оттока крови от мозга. Полученные данные позволяют предположить, что характерные колебания кровоснабжения мозга в ритме дыхательных движений появляются не только в стволе мозга, но и в других отделах. Они, вероятно, связаны с пульсациями венозного оттока вследствие присасывающего влияния грудной полости во время инспирации. The model of periodic apneustic respiration provoked by sodium hydroxybutyrate was used in acute experiments on anaesthetized mongrel male albino rats to examine the blood supply to the region of respiratory center in the brain stem. The development of periodic pathological respiration was associated with specific periodic oscillations of 1) blood flow in the brain stem microvasculature and 2) oxygenation of the nervous tissue following the respiration rhythm. Under these conditions, both blood supply to and venous outflow from the brain were augmented. The study suggested that the characteristic oscillations of blood supply to the brain at the respiration rhythm emerge not only in the brain stem but also in other cerebral regions. Probably, they are caused by oscillations of venous outflow induced by the suction effect of the chest cavity during inspiration.

Neurochemical Changes in Brains of Albino Rats Resulting from Avoidance Learning

1971 ◽  
Vol 28 (1) ◽  
pp. 3-13 ◽  
Author(s):  
Morton H. Kleban ◽  
Martin Gold ◽  
Henry Altschuler ◽  
M. Powell Lawton ◽  
Mark Miller
Keyword(s):  
Brain Stem ◽  
Total Nitrogen ◽  
Avoidance Training ◽  
Straight Runway ◽  
Albino Rats ◽  
Nitrogen Levels ◽  
Neurochemical Changes ◽  
Wistar Albino Rats ◽  
And Behavior ◽  
The Brain

To observe the effects of avoidance training on the brain chemistry of trained rats, 36 Wistar albino rats, 60—75 days old, were run in an automated straight-runway maze. 12 Ss received limited avoidance training followed immediately by extinction training for the avoidance response. 12 other Ss received limited avoidance training only, and 12 is acted as non-trained controls. Following training, each S's brain was removed and sectioned into three gross anatomical parts: cerebrum, brain stem, and cerebellum. Chemical analyses for RNA, protein, and total nitrogen were performed on each brain section for each animal. Significant increases in cerebrum, brain stem, and cerebellum RNA were found for both trained groups. Such differences in RNA were strongly present in the brain stem and cerebrum but were nonsignificant for the cerebellum. Brain protein showed significant increases as a result of the interaction of cerebellum with avoidance training. Total nitrogen levels were unaltered. Two significant correlations obtained between neurochemistry and behavior, a zero-order correlation between brain-stem RNA and extinction behavior and a multiple correlation among brain-stem RNA, cerebral protein, and extinction behavior.

Permeability of the microcirculation in area postrema of rat

1988 ◽  
Vol 46 ◽  
pp. 348-349
Author(s):  
Shams M. Ghoneim ◽  
Frank M. Faraci ◽  
Gary L. Baumbach
Keyword(s):  
Brain Stem ◽  
Area Postrema ◽  
Upper Body ◽  
Sprague Dawley ◽  
Sodium Cacodylate ◽  
Acute Hypertension ◽  
Sprague Dawley Rats ◽  
Ultrastructural Characteristics ◽  
The Brain ◽  
Adjacent Brain

The area postrema is a circumventricular organ in the brain stem and is one of the regions in the brain that lacks a fully functional blood-brain barrier. Recently, we found that disruption of the microcirculation during acute hypertension is greater in area postrema than in the adjacent brain stem. In contrast, hyperosmolar disruption of the microcirculation is greater in brain stem. The objective of this study was to compare ultrastructural characteristics of the microcirculation in area postrema and adjacent brain stem.We studied 5 Sprague-Dawley rats. Horseradish peroxidase was injected intravenously and allowed to circulate for 1, 5 or 15 minutes. Following perfusion of the upper body with 2.25% glutaraldehyde in 0.1 M sodium cacodylate, the brain stem was removed, embedded in agar, and chopped into 50-70 μm sections with a TC-Sorvall tissue chopper. Sections of brain stem were incubated for 1 hour in a solution of 3,3' diaminobenzidine tetrahydrochloride (0.05%) in 0.05M Tris buffer with 1% H2O2.

Surgical Approaches to the Brain Stem

1993 ◽  
Vol 4 (3) ◽  
pp. 457-468 ◽  
Author(s):  
Dennis Y. Wen ◽  
Roberto C. Heros
Keyword(s):  
Brain Stem ◽  
Surgical Approaches ◽  
The Brain

ADRENERGIC INPUTS TO THE AMYGDALA AND THE CONTROL OF GONADOTROPHIN RELEASE

1979 ◽  
Vol 90 (3) ◽  
pp. 385-393 ◽  
Author(s):  
José Borrell ◽  
Flavio Piva ◽  
Luciano Martini
Keyword(s):  
Brain Stem ◽  
Dopamine Receptor ◽  
Serum Levels ◽  
Female Rats ◽  
Receptor Blocker ◽  
Dopaminergic Drug ◽  
Gonadotrophin Secretion ◽  
Biphasic Effect ◽  
Adrenergic Blocker ◽  
The Brain

ABSTRACT Drugs able to mimic or to antagonize the action of catecholamines have been implanted bilaterally into the basomedial region of the amygdala of adult castrated female rats. The animals were killed at different intervals after the implantation of the different drugs, and serum levels of LH and FSH were measured by radioimmunoassay. The results have shown that the intra-amygdalar implantation of the alpha-adrenergic blocker phenoxybenzamine induces a significant increase of the release both of LH and FSH. The implantation of the beta-adrenergic blocker propranolol brings about a rise of LH only. The dopamine receptor blocker pimozide stimulates the release of LH and exerts a biphasic effect (stimulation followed by inhibition) of FSH secretion. The alpha-receptor stimulant clonidine and the dopaminergic drug 2-Br-alpha-ergocryptine were without significant effects. From these observations it is suggested that the adrenergic signals reaching the basomedial area of the amygdala (possibly from the brain stem) may be involved in the modulation of gonadotrophin secretion.

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