Precursors of transient splenic colonies in the mouse embryonic liver

1984 ◽  
Vol 97 (6) ◽  
pp. 806-808
Author(s):  
O. I. Gan ◽  
N. I. Drize ◽  
T. V. Todriya ◽  
I. L. Chertkov
Keyword(s):  
Embryonic Liver ◽  
Splenic Colonies

Nitric Oxide Protects Murine Embryonic Liver Cells (BNL CL.2) from Cytotoxicity Induced by Glucose Deprivation

2000 ◽  
Vol 86 (3) ◽  
pp. 140-144 ◽  
Author(s):  
Hyun-Ock Pae ◽  
Hong-Gone Kim ◽  
Young-Suk Paik ◽  
Sang-Gi Paik ◽  
Young-Myeong Kim ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Glucose Deprivation ◽  
Liver Cells ◽  
Embryonic Liver

scholarly journals Engineering the Vasculature of Stem-Cell-Derived Liver Organoids

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 966
Author(s):  
Xv Zhang ◽  
Liling Tang ◽  
Qian Yi
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Drug Screening ◽  
Disease Modeling ◽  
Liver Development ◽  
Embryonic Liver ◽  
Hepatic Cells ◽  
Hepatic Vessels ◽  
Liver Organoids ◽  
Application Prospects

The vasculature of stem-cell-derived liver organoids can be engineered using methods that recapitulate embryonic liver development. Hepatic organoids with a vascular network offer great application prospects for drug screening, disease modeling, and therapeutics. However, the application of stem cell-derived organoids is hindered by insufficient vascularization and maturation. Here, we review different theories about the origin of hepatic cells and the morphogenesis of hepatic vessels to provide potential approaches for organoid generation. We also review the main protocols for generating vascularized liver organoids from stem cells and consider their potential and limitations in the generation of vascularized liver organoids.

scholarly journals Identifying Candidate Genes for Hypoxia Adaptation of Tibet Chicken Embryos by Selection Signature Analyses and RNA Sequencing

Genes ◽  
2020 ◽  
Vol 11 (7) ◽  
pp. 823
Author(s):  
Xiayi Liu ◽  
Xiaochen Wang ◽  
Jing Liu ◽  
Xiangyu Wang ◽  
Haigang Bao
Keyword(s):  
Candidate Genes ◽  
Rna Sequencing ◽  
Differentially Expressed Genes ◽  
Gallus Gallus ◽  
Differentially Expressed ◽  
Tibet Plateau ◽  
Embryonic Liver ◽  
Selection Signature ◽  
Chicken Embryos ◽  
Hypoxia Adaptation

The Tibet chicken (Gallus gallus) lives on the Qinghai–Tibet Plateau and adapts to the hypoxic environment very well. The objectives of this study was to obtain candidate genes associated with hypoxia adaptation in the Tibet chicken embryos. In the present study, we used the fixation index (Fst) and cross population extended haplotype homozygosity (XPEHH) statistical methods to detect signatures of positive selection of the Tibet chicken, and analyzed the RNA sequencing data from the embryonic liver and heart with HISAT, StringTie and Ballgown for differentially expressed genes between the Tibet chicken and White leghorn (Gallus gallus, a kind of lowland chicken) embryos hatched under hypoxia condition. Genes which were screened out by both selection signature analysis and RNA sequencing analysis could be regarded as candidate genes for hypoxia adaptation of chicken embryos. We screened out 1772 genes by XPEHH and 601 genes by Fst, and obtained 384 and 353 differentially expressed genes in embryonic liver and heart, respectively. Among these genes, 89 genes were considered as candidate genes for hypoxia adaptation in chicken embryos. ARNT, AHR, GSTK1 and FGFR1 could be considered the most important candidate genes. Our findings provide references to elucidate the molecular mechanism of hypoxia adaptation in Tibet chicken embryos.

scholarly journals Heat-induced expression of albumin during early stages of rat embryo development.

1987 ◽  
Vol 7 (12) ◽  
pp. 4599-4602 ◽  
Author(s):  
U K Srinivas ◽  
C J Revathi ◽  
M R Das
Keyword(s):  
Gene Expression ◽  
Heat Shock ◽  
Embryonic Liver ◽  
Rat Embryo ◽  
Adult Liver ◽  
Stages Of Development ◽  
Induced Expression ◽  
Molecular Events ◽  
Internal Change ◽  
Shock Proteins

An examination of heat-induced expression of proteins in tissues from adult and embryonic liver in rats shows that albumin, which is constitutively expressed in adult liver and is not synthesized in embryos before 16 days of gestation, appears in liver cells at earlier stages of development upon heat shock. On the basis of available evidence for the expression of heat shock proteins at distinct stages of development and on the basis of our findings, it may be argued that there could be common molecular events taking place during development and as a result of heat shock. We suggest also that one of the consequences of heat shock could be an internal change of pH within the cell which, in turn, might trigger alterations in gene expression.

Establishment of organ cultures of human embryonic liver for growth of viruses

1972 ◽  
Vol 37 (2-3) ◽  
pp. 230-235 ◽  
Author(s):  
Pamela M. Baines ◽  
Patricia E. Taylor ◽  
A. J. Zuckerman
Keyword(s):  
Embryonic Liver ◽  
Organ Cultures

scholarly journals In vitro formation of osteoclasts from long-term cultures of bone marrow mononuclear phagocytes.

1982 ◽  
Vol 156 (6) ◽  
pp. 1604-1614 ◽  
Author(s):  
E H Burger ◽  
J W Van der Meer ◽  
J S van de Gevel ◽  
J C Gribnau ◽  
G W Thesingh ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Electron Microscopic Examination ◽  
Osteoclast Formation ◽  
Mononuclear Phagocytes ◽  
Long Bone ◽  
Embryonic Liver ◽  
Blood Monocytes ◽  
Electron Microscopic ◽  
Embryonic Mouse

The origin of osteoclasts was studied in an in vitro model using organ cultures of periosteum-free embryonic mouse long-bone primordia, which were co-cultured with various cell populations. The bone rudiments were freed of their periosteum-perichondrium by collagenase treatment in a stage before cartilage erosion and osteoclast formation, and co-cultured for 7 d with either embryonic liver or mononuclear phagocytes from various sources. Light and electron microscopic examination of the cultures showed that mineralized matrix-resorbing osteoclasts developed only in bones co-cultured with embryonic liver or with cultured bone marrow mononuclear phagocytes but not when co-cultured with blood monocytes or resident or exudate peritoneal macrophages. Osteoclasts developed from the weakly adherent, but not from the strongly adherent cells of bone marrow cultures, whereas 1,000 rad irradiation destroyed the capacity of such cultures to form osteoclasts. In bone cultures to which no other cells were added, osteoclasts were virtually absent. Bone-resorbing activity of in vitro formed osteoclasts was demonstrated by 45Ca release studies. These studies demonstrate that osteoclasts develop from cells present in cultures of proliferating mononuclear phagocytes and that, at least in our system, monocytes and macrophages are unable to form osteoclasts. The most likely candidates for osteoclast precursor cells seem to be monoblasts and promonocytes.

Transcriptional and post-transcriptional control of specific messenger RNAs in adult and embryonic liver

1984 ◽  
Vol 179 (1) ◽  
pp. 21-35 ◽  
Author(s):  
D.J. Powell ◽  
J.M. Friedman ◽  
A.J. Oulette ◽  
K.S. Krauter ◽  
J.E. Darnell
Keyword(s):  
Transcriptional Control ◽  
Messenger Rnas ◽  
Embryonic Liver

Embryonic Liver Degeneration and Increased Sensitivity Towards Heavy Metal and H2O2 in Mice Lacking the Metal-Responsive Transcription Factor MTF-1

1999 ◽  
pp. 339-352
Author(s):  
Peter Lichtlen ◽  
Çagatay Günes ◽  
Rainer Heuchel ◽  
Oleg Georgiev ◽  
Karl-Heinz Müller ◽  
...  
Keyword(s):  
Heavy Metal ◽  
Transcription Factor ◽  
Embryonic Liver ◽  
Increased Sensitivity ◽  
Liver Degeneration
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