Electron-microscopic autoradiographic investigation of intracellular RNA synthesis in the mouse cerebral cortex

1977 ◽  
Vol 83 (3) ◽  
pp. 419-422 ◽  
Author(s):  
A. A. Pal'tsyn ◽  
E. Ya. Sanovich ◽  
V. P. Tumanov
Keyword(s):  
Cerebral Cortex ◽  
Rna Synthesis ◽  
Electron Microscopic ◽  
Autoradiographic Investigation ◽  
Mouse Cerebral Cortex

scholarly journals AN ELECTRON MICROSCOPIC STUDY OF THE DEVELOPMENT OF SYNAPSES IN CULTURED FETAL MOUSE CEREBRUM CONTINUOUSLY EXPOSED TO XYLOCAINE

1971 ◽  
Vol 49 (2) ◽  
pp. 362-371 ◽  
Author(s):  
Pat G. Model ◽  
Murray B. Bornstein ◽  
Stanley M. Crain ◽  
George D. Pappas
Keyword(s):  
Cerebral Cortex ◽  
Fine Structure ◽  
Electron Microscope ◽  
Impulse Activity ◽  
Morphological Differentiation ◽  
Bioelectric Activity ◽  
Electron Microscopic ◽  
Fetal Mouse ◽  
Electrical Impulse ◽  
Mouse Cerebral Cortex

Explants of fetal mouse cerebral cortex, continuously exposed to the local anesthetic Xylocaine from the time of explantation to the time of fixation, were examined in the electron microscope to determine whether morphologically normal synapses and potentially functional interneuronal synaptic networks can form in the absence of electrical impulse activity. Morphological differentiation of complex synaptic networks proceeds normally, and the drug does not alter the fine structure of the formed synapses. These observations are consonant with the electrophysiological data which show that the potential for complex bioelectric activity can develop in the absence of its expression. The development and maturation of functional synaptic networks, then, is not contingent upon prior electrical impulse activity. These data support the concept that organized neuronal assemblies are formed in forward reference to their ultimate function.

scholarly journals BMP signaling alters aquaporin-4 expression in the mouse cerebral cortex

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kazuya Morita ◽  
Naoyuki Matsumoto ◽  
Kengo Saito ◽  
Toshihide Hamabe-Horiike ◽  
Keishi Mizuguchi ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Molecular Mechanisms ◽  
Water Movement ◽  
Water Channel ◽  
Bmp Signaling ◽  
Aquaporin 4 ◽  
Mammalian Brain ◽  
Physiological Conditions ◽  
Pathological Conditions ◽  
Mouse Cerebral Cortex

AbstractAquaporin-4 (AQP4) is a predominant water channel expressed in astrocytes in the mammalian brain. AQP4 is crucial for the regulation of homeostatic water movement across the blood–brain barrier (BBB). Although the molecular mechanisms regulating AQP4 levels in the cerebral cortex under pathological conditions have been intensively investigated, those under normal physiological conditions are not fully understood. Here we demonstrate that AQP4 is selectively expressed in astrocytes in the mouse cerebral cortex during development. BMP signaling was preferentially activated in AQP4-positive astrocytes. Furthermore, activation of BMP signaling by in utero electroporation markedly increased AQP4 levels in the cerebral cortex, and inhibition of BMP signaling strongly suppressed them. These results indicate that BMP signaling alters AQP4 levels in the mouse cerebral cortex during development.

scholarly journals Modeling human‐specific interlaminar astrocytes in the mouse cerebral cortex

2020 ◽  
Vol 529 (4) ◽  
pp. 802-810
Author(s):  
Ragunathan Padmashri ◽  
Baiyan Ren ◽  
Braden Oldham ◽  
Yoosun Jung ◽  
Ryan Gough ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Mouse Cerebral Cortex ◽  
Human Specific

scholarly journals Macromolecule biosynthesis: a key function of sleep

2007 ◽  
Vol 31 (3) ◽  
pp. 441-457 ◽  
Author(s):  
Miroslaw Mackiewicz ◽  
Keith R. Shockley ◽  
Micah A. Romer ◽  
Raymond J. Galante ◽  
John E. Zimmerman ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cerebral Cortex ◽  
Sleep Deprivation ◽  
Expression Patterns ◽  
State Level ◽  
Altered Expression ◽  
Mouse Cerebral Cortex ◽  
Genes Encoding ◽  
Function Of Sleep ◽  
Cellular Components

The function(s) of sleep remains a major unanswered question in biology. We assessed changes in gene expression in the mouse cerebral cortex and hypothalamus following different durations of sleep and periods of sleep deprivation. There were significant differences in gene expression between behavioral states; we identified 3,988 genes in the cerebral cortex and 823 genes in the hypothalamus with altered expression patterns between sleep and sleep deprivation. Changes in the steady-state level of transcripts for various genes are remarkably common during sleep, as 2,090 genes in the cerebral cortex and 409 genes in the hypothalamus were defined as sleep specific and changed (increased or decreased) their expression during sleep. The largest categories of overrepresented genes increasing expression with sleep were those involved in biosynthesis and transport. In both the cerebral cortex and hypothalamus, during sleep there was upregulation of multiple genes encoding various enzymes involved in cholesterol synthesis, as well as proteins for lipid transport. There was also upregulation during sleep of genes involved in synthesis of proteins, heme, and maintenance of vesicle pools, as well as antioxidant enzymes and genes encoding proteins of energy-regulating pathways. We postulate that during sleep there is a rebuilding of multiple key cellular components in preparation for subsequent wakefulness.

Gene silencing of NMDA receptor subunit GluN2B disturbs neuronal migration in developing mouse cerebral cortex

2010 ◽  
Vol 68 ◽  
pp. e360
Author(s):  
Takemasa Satoh ◽  
Satomi Hibino ◽  
Yasuaki Shirayoshi ◽  
Ichiro Hisatome ◽  
Yoshio Hata
Keyword(s):  
Cerebral Cortex ◽  
Nmda Receptor ◽  
Gene Silencing ◽  
Neuronal Migration ◽  
Receptor Subunit ◽  
Nmda Receptor Subunit ◽  
Mouse Cerebral Cortex
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