Localization of nerve-specific protein antigens on the surface membrane of neurons and glial cells of Helix pomatia

1979 ◽  
Vol 88 (3) ◽  
pp. 1004-1007
Author(s):  
N. V. Piven' ◽  
V. I. Khichenko ◽  
M. B. Shtark
Keyword(s):  
Glial Cells ◽  
Surface Membrane ◽  
Helix Pomatia ◽  
Specific Protein ◽  
Protein Antigens

The brain-specific protein MLC1 implicated in megalencephalic leukoencephalopathy with subcortical cysts is expressed in glial cells in the murine brain

Glia ◽  
2003 ◽  
Vol 44 (3) ◽  
pp. 283-295 ◽  
Author(s):  
Angelika Schmitt ◽  
Viktor Gofferje ◽  
Melanie Weber ◽  
Jobst Meyer ◽  
Rainald Mössner ◽  
...  
Keyword(s):  
Glial Cells ◽  
Specific Protein ◽  
Murine Brain ◽  
The Brain ◽  
Subcortical Cysts

scholarly journals Novel Protein-Based Pneumococcal Vaccines: Assessing the Use of Distinct Protein Fragments Instead of Full-Length Proteins as Vaccine Antigens

Vaccines ◽  
2019 ◽  
Vol 7 (1) ◽  
pp. 9 ◽  
Author(s):  
Theano Lagousi ◽  
Paraskevi Basdeki ◽  
John Routsias ◽  
Vana Spoulou
Keyword(s):  
Low Cost ◽  
Specific Protein ◽  
Full Length ◽  
Pneumococcal Vaccines ◽  
Protein Antigens ◽  
Protein Fragments ◽  
Humoral And Cellular Immunity ◽  
Expression Variability ◽  
Efficient Protection ◽  
Antigenic Regions

Non-serotype-specific protein-based pneumococcal vaccines have received extensive research focus due to the limitations of polysaccharide-based vaccines. Pneumococcal proteins (PnPs), universally expressed among serotypes, may induce broader immune responses, stimulating humoral and cellular immunity, while being easier to manufacture and less expensive. Such an approach has raised issues mainly associated with sequence/level of expression variability, chemical instability, as well as possible undesirable reactogenicity and autoimmune properties. A step forward employs the identification of highly-conserved antigenic regions within PnPs with the potential to retain the benefits of protein antigens. Besides, their low-cost and stable construction facilitates the combination of several antigenic regions or peptides that may impair different stages of pneumococcal disease offering even wider serotype coverage and more efficient protection. This review discusses the up-to-date progress on PnPs that are currently under clinical evaluation and the challenges for their licensure. Focus is given on the progress on the identification of antigenic regions/peptides within PnPs and their evaluation as vaccine candidates, accessing their potential to overcome the issues associated with full-length protein antigens. Particular mention is given of the use of newer delivery system technologies including conjugation to Toll-like receptors (TLRs) and reformulation into nanoparticles to enhance the poor immunogenicity of such antigens.

Electron cytochemical study of carbogydrate components of surface membrane in cultured glial cells of the snailHelix pomatia

1995 ◽  
Vol 26 (3) ◽  
pp. 147-158 ◽  
Author(s):  
L. M. Koval' ◽  
N. I. Kononenko ◽  
M. D. Lutsik ◽  
E. N. Yavorskaya
Keyword(s):  
Glial Cells ◽  
Surface Membrane ◽  
Cytochemical Study

scholarly journals Regulation of Synthesis of a Brain-Specific Protein in Monolayer Cultures of Clonal Rat Glial Cells

1977 ◽  
Vol 81 (3) ◽  
pp. 591-597 ◽  
Author(s):  
Gerard LABOURDETTE ◽  
James B. MAHONY ◽  
Ian R. BROWN ◽  
Alexander MARKS
Keyword(s):  
Glial Cells ◽  
Specific Protein ◽  
Monolayer Cultures ◽  
Regulation Of Synthesis
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