Effect of high-voltage capacitor discharge on permeability of a cell-membrane model

1974 ◽  
Vol 77 (5) ◽  
pp. 515-516
Author(s):  
I. P. Arleevskii ◽  
V. K. Bezuglov
Keyword(s):  
Cell Membrane ◽  
High Voltage ◽  
Membrane Model ◽  
Capacitor Discharge ◽  
A Cell ◽  
Cell Membrane Model

Synthesis of imidazolium-terminated carbosilane dendrimers and dendrons and study of their interactions with a cell membrane model

2020 ◽  
Vol 133 ◽  
pp. 109748 ◽  
Author(s):  
Tamara Rodríguez-Prieto ◽  
Alberto Fattori ◽  
Claudimar Camejo ◽  
F. Javier de la Mata ◽  
Jesús Cano ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Membrane Model ◽  
Carbosilane Dendrimers ◽  
A Cell ◽  
Cell Membrane Model

scholarly journals Antituberculosis Drug Interactions with Membranes: A Biophysical Approach Applied to Bedaquiline

Membranes ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 141
Author(s):  
Marina Pinheiro ◽  
Heinz Amenitsch ◽  
Salette Reis
Keyword(s):  
Cell Membrane ◽  
Eukaryotic Cell ◽  
Membrane Model ◽  
Molar Ratio ◽  
X Ray ◽  
X Ray Scattering ◽  
Membrane Models ◽  
Bacterial Cell Membrane ◽  
Cell Membrane Model ◽  
Ray Scattering

This work focuses on the interaction of the novel and representative antituberculosis (anti-TB) drug bedaquiline (BDQ) with different membrane models of eukaryotic and prokaryotic cells. The effect of BDQ on eukaryotic cell membrane models was assessed using liposomes, namely, multilamellar vesicles (MLVs) made of 1,2-dimyristoyl-rac-glycero-3-phosphocholine (DMPC) and also a mixture of DMPC and cholesterol (CHOL) (8:2 molar ratio). To mimic the prokaryotic cell membrane, 1,2-dimyristoyl-sn-glycero-3-phospho-rac-(1-glycerol) (DMPG) and 1,1′2,2′-tetra-oleoyl-cardiolipin (TOCL) were chosen. Powerful biophysical techniques were employed, including small-angle X-ray scattering (SAXS) and wide-angle X-ray scattering (WAXS), to understand the effect of BDQ on the nanostructure of the membrane models. The results showed that BDQ demonstrated a pronounced disordering effect in the bacterial cell membrane models, especially in the membrane model with cardiolipin (CL), while the human cell membrane model with large fractions of neutral phospholipids remained less affected. The membrane models and techniques provide detailed information about different aspects of the drug–membrane interaction, thus offering valuable information to better understand the effect of BDQ on their target membrane-associated enzyme as well as its side effects on the cardiovascular system.

INTERACTION OF LOCAL ANESTHETICS AND CELL MEMBRANE MODEL

1979 ◽  
Vol 51 (3) ◽  
pp. S231-S231
Author(s):  
H. Goto ◽  
D. Shieh ◽  
K. Arakawa
Keyword(s):  
Cell Membrane ◽  
Local Anesthetics ◽  
Membrane Model ◽  
Cell Membrane Model
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