Experimental study of the effect of lithium hydroxybutyrate on the circadian rest-activity rhythm and sleep structure

1992 ◽  
Vol 113 (2) ◽  
pp. 196-198
Author(s):  
T. A. Zamoshchina ◽  
A. V. Matveenko ◽  
A. S. Saratikov
Keyword(s):  
Experimental Study ◽  
Activity Rhythm ◽  
Lithium Hydroxybutyrate ◽  
Sleep Structure ◽  
Rest Activity

Alterations of the Characteristics of the Circadian Rest‐Activity Rhythm of Cancer In‐Patients

2007 ◽  
Vol 24 (6) ◽  
pp. 1179-1197 ◽  
Author(s):  
Atanu Kumar Pati ◽  
Arti Parganiha ◽  
Anjana Kar ◽  
Rakesh Soni ◽  
Sushmita Roy ◽  
...  
Keyword(s):  
Activity Rhythm ◽  
Rest Activity

scholarly journals Effects of High-Frequency Cranial Electrostimulation on the Rest-Activity Rhythm and Salivary Cortisol in Alzheimer’s Disease

2006 ◽  
Vol 22 (4) ◽  
pp. 267-272 ◽  
Author(s):  
Erik Scherder ◽  
Dirk Knol ◽  
Marie-Jose van Tol ◽  
Eus van Someren ◽  
Jan-Berend Deijen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Salivary Cortisol ◽  
High Frequency ◽  
Activity Rhythm ◽  
Rest Activity

Simulating the action of zeitgebers on a coupled two-oscillator model of the human circadian system

1984 ◽  
Vol 247 (3) ◽  
pp. R418-R426
Author(s):  
P. H. Gander ◽  
R. E. Kronauer ◽  
C. A. Czeisler ◽  
M. C. Moore-Ede
Keyword(s):  
Core Temperature ◽  
Activity Rhythm ◽  
Human Subjects ◽  
Model Performance ◽  
The Other ◽  
Oscillator Model ◽  
Temporal Isolation ◽  
The Core ◽  
Temperature Rhythm ◽  
Rest Activity

Our two-oscillator model was originally designed to describe the circadian rhythms of human subjects maintained in temporal isolation. The performance of this model in response to simulated environmental synchronizing cycles (zeitgebers) is examined here. Six distinct types of synchronization are demonstrated between the x oscillator (postulated to regulate the core temperature rhythm), the y oscillator (postulated to regulate the rest-activity rhythm), and z (the zeitgeber). Four types of synchronization are identifiable, if we consider only the periods of the three oscillators. Both x and y may be synchronized by z; either may synchronize with z while the other exhibits a different period; or x, y, and z may each show different periods. Two further classes of synchronization are discernible when phase criteria are taken into account. When either x or y is on the verge of desynchronizing from the other two oscillators, it undergoes periodic phase modulations while retaining the common overall period. The type of synchronization observed depends on the periods of x, y, and z and on the strength of the z drive. The effects of modifying each of these parameters have been systematically investigated by simulation, and model performance is summarized in terms of range of entrainment "maps." These constitute extensive sets of predictions about expected patterns of entrainment of the core temperature and rest-activity rhythms of human subjects exposed to various environmental zeitgebers. Experimental data are available against which model predictions can be tested.

scholarly journals Effects of Dynamic Bedroom Lighting On Measures of Sleep and Circadian Rest-Activity Rhythm in Inpatients With Major Depressive Disorder

2021 ◽  
Author(s):  
Canazei Markus ◽  
Weninger Johannes ◽  
Pohl Wilfried ◽  
Marksteiner Josef ◽  
Weiss Elisabeth
Keyword(s):  
Activity Rhythm ◽  
Severe Depression ◽  
Bright Light ◽  
Light Therapy ◽  
Psychiatric Ward ◽  
Lighting System ◽  
Bright Light Therapy ◽  
Effective Treatment Option ◽  
Major Depressive ◽  
Rest Activity

Abstract Bright light therapy is an effective treatment option for seasonal and non-seasonal affective disorders. However up to now, no study has investigated effects of dynamic bedroom lighting in hospitalized patients with major depression. A bedroom lighting system, which automatically delivered artificial dawn and dusk and blue-depleted nighttime lighting (DD-N lighting) was installed in a psychiatric ward. Patients with moderate to severe depression were randomly assigned to stay in bedrooms with the new lighting or standard lighting system. Patients wore wrist actimeters during the first two treatment weeks. Additionally, hospitalization duration and daily psychotropic medication were retrieved from patients’ medical charts. Data from thirty patients were analyzed. Patients under DD-N lighting generally woke up earlier (+20 minutes), slept longer (week 1: +11 min; week 2: +27 min) and showed higher sleep efficiency (+2.4%) and shorter periods of nighttime awakenings (-15 minutes). In the second treatment week, patients started sleep and the most active 10-hour period earlier (-33 min and -64 min, respectively). This pilot study gives first evidence that depressed patients’ sleep and circadian rest/activity system may benefit from adjunctive bedroom lighting when starting inpatient treatment.

Rest-activity rhythm of the blind mole rat Spalax ehrenbergi under different lighting conditions

1998 ◽  
Vol 96 (1-2) ◽  
pp. 173-183 ◽  
Author(s):  
Irene Tobler ◽  
Miriam Herrmann ◽  
Howard M Cooper ◽  
Julia Negroni ◽  
Eviatar Nevo ◽  
...  
Keyword(s):  
Activity Rhythm ◽  
Spalax Ehrenbergi ◽  
Lighting Conditions ◽  
Mole Rat ◽  
Rest Activity

scholarly journals Cancer Bereavement and Depression Symptoms in Older Spouses: The Possible Modifying Role of the Circadian Rest-Activity Rhythm

2020 ◽  
pp. 1-7
Author(s):  
Sarah T. Stahl ◽  
Ioana Neagoe ◽  
Stephen F. Smagula ◽  
Donna Posluszny ◽  
Dana H. Bovbjerg
Keyword(s):  
Activity Rhythm ◽  
Depression Symptoms ◽  
Rest Activity

scholarly journals Desflurane anesthesia shifts the circadian rhythm phase depending on the time of day of anesthesia

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ryo Imai ◽  
Hiroshi Makino ◽  
Takasumi Katoh ◽  
Tetsuro Kimura ◽  
Tadayoshi Kurita ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Phase Shift ◽  
Clock Genes ◽  
Activity Rhythm ◽  
Time Of Day ◽  
Prevention And Treatment ◽  
The Relationship ◽  
Relative Mrna Expression ◽  
Master Clock ◽  
Rest Activity

Abstract Desflurane is one of the most frequently used inhalational anesthetics in clinical practice. A circadian rhythm phase-shift after general anesthesia with sevoflurane or isoflurane has been reported in mice, but few studies have reported this effect with desflurane. In the present study, we examined the rest/activity rhythm of mice by counting the number of running wheel rotations, and we found that desflurane anesthesia caused a phase shift in the circadian rhythm that was dependent on the time of day of anesthesia. We also found that desflurane anesthesia altered the relative mRNA expression of four major clock genes (Per2, Bmal, Clock, and Cry1) in the suprachiasmatic nucleus (SCN). These results are important for elucidating the effects of desflurane on the SCN, which is the master clock for the mammalian circadian rhythm. Further studies on the relationship between anesthesia and circadian rhythm may lead to the prevention and treatment of postoperative complications related to circadian rhythms.

scholarly journals 0813 Circadian Rest-activity Rhythm In Isolated Rem Sleep Behavior Disorder

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A309-A309
Author(s):  
A Stefani
Keyword(s):  
Motor Activity ◽  
Rem Sleep ◽  
Activity Rhythm ◽  
Sleep Apnea Syndrome ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Healthy Controls ◽  
Sleep Behavior ◽  
Screening Questionnaires ◽  
Rest Activity

Abstract Introduction Isolated REM sleep behavior disorder (iRBD) is a parasomnia characterized by abnormal behaviours occurring during REM sleep. Several studies showed that iRBD is a prodromal stage of synucleinopathies. Therefore identifying iRBD in the general population is of utmost importance. Aim of this study was to explore whether the assessment of circadian rest-activity rhythm features, measured by actigraphy, can distinguish iRBD patients from patients suffering from disorders characterized by other pathological motor activity during sleep and healthy controls. Methods Nineteen subjects with video-polysomnographic (v-PSG) diagnosis of iRBD, 39 subjects with other disorders with motor activity during sleep (19 restless leg syndrome -RLS- and 20 untreated sleep apnea syndrome patients -SAS) and 16 healthy controls underwent 2-week actigraphy, v-PSG, and completed RBD screening questionnaires. Nonparametric analyses were applied to assess rest-activity rhythm features; daytime napping was also evaluated. The diagnostic value of nonparametric measures has been assessed through ROC curve. Results iRBD patient showed lower sleep efficiency, increased WASO and increased frequency of prolonged activity bouts compared to RLS and controls, while no difference emerged with SAS patients. Moreover, iRBD patients presented increased occurrence of estimated nap in comparison to RLS, SAS and controls. The nonparametric measure I<O distinguished iRBD patients from RLS, SAS and controls with an area under the curve greater than that of RBD screening questionnaires. Conclusion The nonparametric index I<O is able to distinguish iRBD patients from patients with other pathological motor activity during sleep and controls, confirming its potential use as an objective measure suitable to screen large at-risk populations. Support This study was supported by a grant from the Austrian Science Fund (FWF) to Birgit Högl, I 2120-B27.

scholarly journals Effects of Low-Frequency Cranial Electrostimulation on the Rest-Activity Rhythm and Salivary Cortisol in Alzheimer's Disease

2003 ◽  
Vol 17 (2) ◽  
pp. 101-108 ◽  
Author(s):  
Erik Scherder ◽  
Dirk Knol ◽  
Eus van Someren ◽  
Jan-Berend Deijen ◽  
Rob Binnekade ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Activity Rhythm ◽  
Low Frequency ◽  
Control Group ◽  
Positive Effects ◽  
Alternative Research ◽  
Positive Effect ◽  
Experimental Group ◽  
Rest Activity

Objective. In previous studies, cranial electrostimulation (CES) had positive effects on sleep in depressed patients and in patients with vascular dementia. The present study examined the effects of low-frequency CES on the rest-activity rhythm and cortisol levels of patients with probable Alzheimer's disease (AD). Method. It was hypothesised that a decreased level of cortisol would parallel a positive effect of low-frequency CES on nocturnal restlessness. Sixteen AD patients were randomly assigned to an experimental group (n = 8) or a control group (n = 8). The experimental group was treated with CES, whereas the control group received sham stimulation, for 30 minutes a day, during 6 weeks. The rest-activity rhythm was assessed by actigraphy. Cortisol was measured repeatedly in the saliva throughout the day by means of salivette tubes. Results. Low-frequency CES did not improve the rest-activity rhythm in AD patients. Moreover, both groups showed an increase instead of a decrease in the level of cortisol. Conclusions: These preliminary results suggest that low-frequency CES has no positive effect on the rest-activity rhythm in AD patients. An alternative research design with high-frequency CES in AD is discussed.

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