Mechanical properties and effects of sympathetic co-transmitters on human coronary arteries and veins

1997 ◽  
Vol 92 (3) ◽  
pp. 168-180 ◽  
Author(s):  
O. Saetrum Opgaard ◽  
L. Edvinsson
Keyword(s):  
Mechanical Properties ◽  
Coronary Arteries ◽  
Arteries And Veins

The Coronary Arteries and Veins

2020 ◽  
pp. 107-130
Author(s):  
Francesco F. Faletra ◽  
Marco Araco ◽  
Laura A. Leo ◽  
Giovanni Pedrazzini ◽  
Tiziano Moccetti ◽  
...  
Keyword(s):  
Coronary Arteries ◽  
Arteries And Veins

The Mechanical Properties of Porcine Coronary Arteries Determined With a Mixed Experimental-Numerical Approach

2008 ◽  
Author(s):  
Arjen van der Horst ◽  
Chantal N. van den Broek ◽  
Marcel C. M. Rutten ◽  
Frans N. van de Vosse
Keyword(s):  
United States ◽  
Mechanical Properties ◽  
Coronary Arteries ◽  
Arterial Wall ◽  
Coronary Circulation ◽  
Mechanical Characterization ◽  
Numerical Approach ◽  
The United States ◽  
Mechanical Factors

Mechanical characterization of the coronary arterial wall is important for several reasons. Mechanical factors play an important role in the development of atherosclerosis [1]. Atherosclerotic coronary arteries may be treated mechanically with interventions like PTCA and stent implantation, 1265000 PTCA procedures were performed in the United States in 2005 [2]. Furthermore, knowledge of the mechanical properties of the arterial wall is important for modeling of the coronary circulation and explaining its hemodynamics.

scholarly journals Effect of cigarette smoking on nitric oxide, structural, and mechanical properties of mouse arteries

2006 ◽  
Vol 291 (5) ◽  
pp. H2354-H2361 ◽  
Author(s):  
X. Guo ◽  
M. J. Oldham ◽  
M. T. Kleinman ◽  
R. F. Phalen ◽  
G. S. Kassab
Keyword(s):  
Nitric Oxide ◽  
Mechanical Properties ◽  
Elastic Modulus ◽  
Cigarette Smoking ◽  
Coronary Arteries ◽  
Short And Long Term ◽  
By Products ◽  
Enos Protein

Cigarette smoking (CS) is a major risk factor for vascular disease. The aim of this study was to quantitatively assess the influence of CS on mouse arteries. We studied the effect of short-term (6 wk) and long-term (16 wk) CS exposure on structural and mechanical properties of coronary arteries compared with that of control mice. We also examined the reversibility of the deleterious effects of CS on structural [e.g., wall thickness (WT)], mechanical (e.g., stiffness), and biochemical [e.g., nitric oxide (NO) by-products] properties with the cessation of CS. The left and right coronary arteries were cannulated in situ and mechanically distended. The stress, strain, elastic modulus, and WT of coronary arteries were determined. Western blot analysis was used to analyze endothelial NO synthase (eNOS) in the femoral and carotid arteries of the same mice, and NO by-products were determined by measuring the levels of nitrite. Our results show that the mean arterial pressure was increased by CS. Furthermore, CS significantly increased the elastic modulus, decreased stress and strain, and increased the WT and WT-to-radius ratio compared with those of control mice. The reduction of eNOS protein expression was found only after long-term CS exposure. Moreover, the NO metabolite was markedly decreased in CS mice after short- and long-term exposure of CS. These findings suggest that 16 wk of CS exposure can cause an irreversible deterioration of structural and elastic properties of mouse coronary arteries. The decrease in endothelium-derived NO in CS mice was seen to significantly correlate with the remodeling of arterial wall.

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