Immunologic response of mouse spleen cells during induction of tolerance in the early postnatal period

1970 ◽  
Vol 69 (5) ◽  
pp. 548-549
Author(s):  
I. N. Maiskii ◽  
G. P. Airapet'yan ◽  
T. A. Pokrovskaya
Keyword(s):  
Postnatal Period ◽  
Early Postnatal Period ◽  
Mouse Spleen ◽  
Immunologic Response ◽  
Spleen Cells ◽  
Induction Of Tolerance

Antibody-synthesizing function of the mouse spleen in the early postnatal period

1969 ◽  
Vol 68 (3) ◽  
pp. 1014-1015
Author(s):  
I. N. Maiskii ◽  
T. A. Pokrovskaya ◽  
G. P. Airapet'yan
Keyword(s):  
Postnatal Period ◽  
Early Postnatal Period ◽  
Mouse Spleen

scholarly journals Specific elimination of cytotoxic effector cells. I. Adsorptive behavior of effectors and their precursors and spleen cell monolayers.

1976 ◽  
Vol 144 (4) ◽  
pp. 996-1008 ◽  
Author(s):  
J R Neefe ◽  
D H Sachs
Keyword(s):  
Mouse Spleen ◽  
Spleen Cells ◽  
Effector Cells ◽  
Cell Monolayers ◽  
Specific Suppression ◽  
Normal Spleen ◽  
Adsorptive Behavior ◽  
Cytotoxic Effector ◽  
Primed Mouse

Monolayers formed of normal mouse spleen cells attached to polystyrene coated with poly-L-lysine were tested for their ability to bind specifically antigen-reactive cells in normal or primed mouse spleen. 88 to greater than 98% of the activity of cytotoxic populations was removed by a single adsorption. However, normal spleen cells or spleen cells previously primed in vitro could not be depleted of their capacity to be sensitized, even when adsorption effectively removed all residual cytotoxic activity from the same previously primed population. In fact, exposure to an immunoadsorbent augmented the ultimate cytotoxicity generated in a nonspecific fashion. This augmentation was especially dramatic in the case of a previously primed population and may have reflected the removal of a nonspecific suppressor. If antigen-reactive precursors cannot be removed efficiently by adsorption, other approaches to the generation of tolerant lymphoid populations, such as specific suppression of precursor differentiation must be sought.

scholarly journals Changes in pituitary secretion during the early postnatal period and anovulatory syndrome induced by neonatal oestrogen or androgen in rats

Reproduction ◽  
1993 ◽  
Vol 97 (1) ◽  
pp. 13-20 ◽  
Author(s):  
L. Pinilla ◽  
E. Trimino ◽  
P. Garnelo ◽  
C. Bellido ◽  
R. Aguilar ◽  
...  
Keyword(s):  
Postnatal Period ◽  
Early Postnatal Period ◽  
Pituitary Secretion
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