Conditioned reflex regulation of the serum globulin level

1964 ◽  
Vol 55 (6) ◽  
pp. 664-666 ◽  
Author(s):  
V. I. Luk'yanenko ◽  
B. A. Flerov ◽  
O. Ya. Megreladze ◽  
S. M. Kuznetsov
Keyword(s):  
Conditioned Reflex ◽  
Serum Globulin ◽  
Reflex Regulation ◽  
Globulin Level

A low albumin to globulin ratio with a high serum globulin level is a prognostic marker for poor survival in cervical cancer patients treated with radiation based therapy

2019 ◽  
Vol 29 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Yasunori Yoshino ◽  
Ayumi Taguchi ◽  
Takuya Shimizuguchi ◽  
Yujiro Nakajima ◽  
Maki Takao ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Overall Survival ◽  
Serum Albumin ◽  
Cancer Patients ◽  
Serum Albumin Level ◽  
Albumin Level ◽  
High Serum ◽  
Serum Globulin ◽  
Globulin Level ◽  
Albumin To Globulin Ratio

ObjectiveWe investigated whether the pretreatment albumin to globulin ratio, serum albumin level, and serum globulin level can be used to predict survival among cervical cancer patients treated with radiation based therapy and assessed globulin fractions.MethodsWe retrospectively enrolled 128 patients with cervical cancer treated with radiation based therapy at our institution between 2010 and 2015. The associations of the pretreatment albumin to globulin ratio, and serum albumin and globulin levels with overall survival were assessed. Additionally, the associations of the globulin fractions with the serum globulin levels and overall survival were evaluated.ResultsMedian follow-up duration was 30 months (IQR 16–44 months). A low albumin to globulin ratio (< 1.53) was found to be an independent prognostic factor for overall survival (HR= 3.07; 95% CI, 1.03 to 13.3; P=0.044). On evaluating serum globulin and albumin separately, a high serum globulin level was significantly associated with overall survival (cut-off value 2.9 g/dL; HR=3.74; 95% CI 1.08 to 23.6; P=0.036) whereas a low serum albumin level was not associated with overall survival (cut-off value 3.6 g/dL; HR=1.77; 95% CI 0.57 to 4.54; P=0.29). Electrophoresis data of the serum proteins revealed that the γ-globulin fraction was most strongly correlated with the globulin levels (P<0.001). Furthermore, a high γ-globulin level (≥1.28 g/dL) was significantly associated with poor overall survival (log rank test, P=0.034).ConclusionsA pretreatment low albumin to globulin ratio, which might be attributable to a high serum globulin level, can be used to predict poor prognosis in cervical cancer patients treated with radiation based therapy.

scholarly journals Dietary Fibers (Gum Arabic) Supplementation Modulates Hepatic and Renal Profile Among Rheumatoid Arthritis Patients, Phase II Trial

2021 ◽  
Vol 8 ◽  
Author(s):  
Ebtihal Kamal ◽  
Lamis AbdelGadir Kaddam ◽  
Alnour Alagib ◽  
Amal Saeed
Keyword(s):  
Rheumatoid Arthritis ◽  
Alkaline Phosphatase ◽  
Serum Albumin ◽  
Total Protein ◽  
Liver Enzymes ◽  
Gum Arabic ◽  
Protective Effects ◽  
Soluble Fiber ◽  
Serum Globulin ◽  
Globulin Level

Background: Rheumatoid arthritis (RA) is an autoimmune disease that mainly affects the synovial joints with systemic manifestations. RA has a major impact on liver and kidney functions as part of the disease pathogenesis or as a sequel of disease medications or, mostly, both of them. The kidney and liver involvement increases the RA morbidity and mortality. Nowadays, dietary interventions are proposed as potential modifiers for disease severity. Gum Arabic (GA) is acacia senegal exudates; it is soluble fiber with prebiotic properties. GA has been discovered to be protective against experimental nephrotoxicity and hepatotoxicity, with comparable findings in human studies. This article addresses the effect of GA on hepatic and renal profile among RA patients.Methods: Forty patients aged 18–70 received GA daily for 12 weeks as a single dose of 30 g. The liver enzymes, total protein level, serum albumin, serum globulin level, urea, creatinine, and serum electrolytes have been measured as a baseline after 4 weeks and by the end of the study. Cobas C311 (Roche, Germany) automated chemistry analyzer directly determined the values for total protein, albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and creatinine. The study ethically has been approved by the Ethical Committee of the National Medicines and Poisons Board. Trial Registration Identifier: NCT02804581.Results: Regarding the liver enzymes, GA has significantly decreased the liver enzymes apart from alkaline phosphatase, which showed no significant change. In contrast, GA has increased the serum albumin level with a minor impact on the serum globulin level. Furthermore, GA has also significantly decreased the level of urea (P = 0.0001) and level of Sodium (P = 0.002) with nonsignificant change on creatinine and potassium concentrations.Conclusion: GA presents hepatic and renal protective effects among RA patients, evidenced by the significant reduction of urea and liver enzymes. Thus, it can be recommended as a dietary supplement for RA patients. Nonetheless, we recommend further investigation to support our findings.

Properties of Washed Human Platelets

1977 ◽  
Vol 37 (02) ◽  
pp. 291-308 ◽  
Author(s):  
Raelene L Kinlough-Rathbone ◽  
J Fraser Mustard ◽  
Marian A Packham ◽  
Dennis W Perry ◽  
Hans-Joachim Reimers ◽  
...  
Keyword(s):  
Major Effect ◽  
Human Platelets ◽  
Immune Serum ◽  
Immune Serum Globulin ◽  
Serum Globulin ◽  
Platelet Adherence ◽  
Low Concentrations ◽  
Induced Aggregation ◽  
Extensive Release ◽  
Protein Free Medium

SummaryWe have shown previously that washed human platelets resuspended in Tyrode solution containing albumin and apyrase maintain their disc shape and their ability to aggregate upon the addition of low concentrations of ADP, providing fibrinogen is added to the suspending medium. We have now examined their responses to other aggregating and release-inducing agents. Collagen, arachidonate, thrombin, immune serum globulin, the ionophore A 23, 187 and phytohaemagglutinin from Phaseolus vulgaris caused aggregation and release of granule contents. The response to adrenaline was variable. Serotonin caused the platelets to change shape but no aggregation or release occurred. Addition of a small amount of plasma was necessary for ristocetin-induced aggregation. Polylysine caused immediate platelet-to-platelet adherence with little or no release of granule contents. Responses to collagen or thrombin were greater in a modified medium containing magnesium but no calcium; in this medium, aggregation caused by ADP or polylysine was followed by the release of granule contents whereas these agents caused aggregation without release in a medium with both calcium and magnesium. When protein was omitted from the suspending medium, platelet aggregation in response to ADP was variable. In this medium, collagen and thrombin caused more extensive release than in the albumin-containing medium. Aggregation by polylysine was accompanied by release and extensive lysis in the protein-free medium. Thus, the composition of the final resuspending medium has a major effect on the responses of washed human platelets to aggregating agents.

INFLUENCE OF SODIUM THIOPENTAL ON CONSERVATION OF CONDITIONAL REFLEX OF PASSIVE AVOIDANCE IN RATS WITH DIFFERENT NERRVOUS SYSTEM EXCITABILITY

2018 ◽  
pp. 8-11
Author(s):  
A. V. Shvetsov ◽  
A. I. Vaido ◽  
N. A. Dyuzhikova ◽  
A. V. Belskaya ◽  
M. V. Mikhailova ◽  
...  
Keyword(s):  
Nervous System ◽  
Passive Avoidance ◽  
Avoidance Response ◽  
Conditioned Reflex ◽  
Lethal Dose ◽  
Conditional Reflex ◽  
Passive Avoidance Response ◽  
Sodium Thiopental ◽  
Higher Sensitivity

A study of the dynamics of preservation of the conditioned reflex of passive avoidance (passive avoidance response) in rats of two lines with different level of excitability of the nervous system was performed: with a high and low thresholds of excitability as normal and after exposure to sodium thiopental semi-lethal dose. It was shown that a long preservation of the memorable trace under standard conditions and a higher sensitivity to the sodium thiopental action manifest in rats with a high excitability threshold in comparison with low-excitable line of rats.

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