Changes in the phagocytic reaction and in organs of the reticulo-endothelial system in albino mice following administration of tetracycline

1966 ◽  
Vol 61 (2) ◽  
pp. 168-171
Author(s):  
T. F. Koshik
1972 ◽  
Vol 74 (4) ◽  
pp. 1284-1286
Author(s):  
G. E. Arkad'eva ◽  
G. A. Vitovskaya ◽  
N. P. Elinov ◽  
M. A. Kashkina ◽  
A. P. Kashkin ◽  
...  

Author(s):  
O. T. Minick ◽  
E. Orfei ◽  
F. Volini ◽  
G. Kent

Hemolytic anemias were produced in rats by administering phenylhydrazine or anti-erythrocytic (rooster) serum, the latter having agglutinin and hemolysin titers exceeding 1:1000.Following administration of phenylhydrazine, the erythrocytes undergo oxidative damage and are removed from the circulation by the cells of the reticulo-endothelial system, predominantly by the spleen. With increasing dosage or if animals are splenectomized, the Kupffer cells become an important site of sequestration and are greatly hypertrophied. Whole red cells are the most common type engulfed; they are broken down in digestive vacuoles, as shown by the presence of acid phosphatase activity (Fig. 1). Heinz body material and membranes persist longer than native hemoglobin. With larger doses of phenylhydrazine, erythrocytes undergo intravascular fragmentation, and the particles phagocytized are now mainly red cell fragments of varying sizes (Fig. 2).


2011 ◽  
Vol 3 (8) ◽  
pp. 680-684 ◽  
Author(s):  
Faiza Rifat ◽  
◽  
Archana Sharma ◽  
Preeti Srivastava ◽  
Shikha Patni ◽  
...  

2017 ◽  
Vol 2017 (Special-2) ◽  
pp. 152-160
Author(s):  
Galawezh Obaid Othman ◽  
◽  
Nadhum jalal Esmaeil ◽  

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