Use of the characteristics of the adsorption state of substances in correlations of chemical structure with biological activity. II. Relationship of the surface activity of naphthenic acids to their influence on the permeability of ascites tumor cells to potassium ions

In this study, new biodegradable and biocompatible amphiphilic polymers were obtained by modifying the peripheral hydroxyl groups of branched polyethers and polyesters with organosilicon substituents. The structures of the synthesized polymers were confirmed by NMR and GPC. Organosilicon moieties of the polymers were formed by silatranes and trimethylsilyl blocks and displayed hydrophilic and hydrophobic properties, respectively. The effect of the ratio of hydrophilic to hydrophobic organosilicon structures on the surface activity and biological activity of macromolecules was studied, together with the effect on these activities of the macromolecules’ molecular weight and chemical structure. In particular, the critical micelle concentrations were determined, the effect of the structure of the polymers on their wetting with aqueous solutions on glass and parafilm was described, and the aggregation stability of emulsions was studied. Finally, the effect of the polymer structures on their antifungal activity and seed germination stimulation was examined.

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Use of the characteristic adsorption state of substances in the correlative relations of chemical structure to biological activity

Pharmaceutical Chemistry Journal ◽

10.1007/bf01156487 ◽

1977 ◽

Vol 11 (4) ◽

pp. 488-491

Author(s):

N. A. Epstein ◽

S. V. Nizhii

Keyword(s):

Biological Activity ◽

Chemical Structure ◽

Adsorption State ◽

Characteristic Adsorption

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Specific drug sensitive transport pathways for chloride and potassium ions in steady-state ehrlich mouse ascites tumor cells

Biochimica et Biophysica Acta (BBA) - Biomembranes ◽

10.1016/0005-2736(82)90287-5 ◽

1982 ◽

Vol 688 (3) ◽

pp. 740-746 ◽

Cited By ~ 21

Author(s):

Felice Aull

Keyword(s):

Steady State ◽

Tumor Cells ◽

Potassium Ions ◽

Specific Drug ◽

Ascites Tumor ◽

Transport Pathways ◽

Mouse Ascites

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Relationship of chemical structure to biological activity

Elements of Pharmacology ◽

10.1017/cbo9780511565656.010 ◽

1981 ◽

pp. 72-78

Keyword(s):

Biological Activity ◽

Chemical Structure ◽

Relationship Of

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Computing Eccentricity Based Topological Indices of Octagonal Grid Omn

Mathematics ◽

10.3390/math6090153 ◽

2018 ◽

Vol 6 (9) ◽

pp. 153 ◽

Cited By ~ 5

Author(s):

Xiujun Zhang ◽

Muhammad Siddiqui ◽

Muhammad Naeem ◽

Abdul Baig

Keyword(s):

Biological Activity ◽

Chemical Structure ◽

Acid Hydrazide ◽

Graph Invariants ◽

Eccentric Connectivity Index ◽

Zagreb Index ◽

Carboxylic Acid Hydrazide ◽

Relationship Of ◽

The Relationship ◽

Connective Index

Graph theory is successfully applied in developing a relationship between chemical structure and biological activity. The relationship of two graph invariants, the eccentric connectivity index and the eccentric Zagreb index are investigated with regard to anti-inflammatory activity, for a dataset consisting of 76 pyrazole carboxylic acid hydrazide analogs. The eccentricity ε v of vertex v in a graph G is the distance between v and the vertex furthermost from v in a graph G. The distance between two vertices is the length of a shortest path between those vertices in a graph G. In this paper, we consider the Octagonal Grid O n m . We compute Connective Eccentric index C ξ ( G ) = ∑ v ∈ V ( G ) d v / ε v , Eccentric Connective Index ξ ( G ) = ∑ v ∈ V ( G ) d v ε v and eccentric Zagreb index of Octagonal Grid O n m , where d v represents the degree of the vertex v in G.

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