The bacteriostatic activity of certain azomethine derivatives of amino and sulfonic acids

1972 ◽  
Vol 6 (9) ◽  
pp. 577-579
Author(s):  
M. D. Aptekar' ◽  
E. P. Trailina ◽  
L. K. Gul'chenko ◽  
I. A. Savin
Keyword(s):  
Bacteriostatic Activity ◽  
Sulfonic Acids ◽  
Derivatives Of

Thallous Salts as Derivatives of Sulfonic Acids

1943 ◽  
Vol 65 (1) ◽  
pp. 123-124
Author(s):  
Henry Gilman ◽  
R. K. Abbott
Keyword(s):  
Sulfonic Acids ◽  
Derivatives Of

scholarly journals Studies on the antibacterial properties of some basic derivatives of cholane and norcholane

1947 ◽  
Vol 134 (877) ◽  
pp. 538-543 ◽  
Keyword(s):  
Staphylococcus Aureus ◽  
Surface Tension ◽  
Antibacterial Activity ◽  
Antibacterial Properties ◽  
Lactobacillus Helveticus ◽  
Bacteriostatic Activity ◽  
Gram Positive ◽  
Gram Negative ◽  
Derivatives Of

A series of basic derivatives of cholane and norcholane has been examined for bacteriostatic activity against the Gram-positive Staphylococcus aureus and Lactobacillus helveticus and the Gram-negative Bacillus lactis aerogenes . The basic derivatives, in general, were more highly bacteriostatic against the Gram-positive organisms than against the Gram-negative. Of the compounds studied, the highest antibacterial activity was shown by 3:7:12-trihydroxy-23-guanido-norcholane hydrochloride. No relationship was apparent between the lowering of the surface tension of the medium induced by the compounds and their bacteriostatic activity.

ChemInform Abstract: Synthesis, Immunomodulating, and Cytoprotective Activity of Novel Azolide Derivatives of Sulfonic Acids.

ChemInform ◽  
2010 ◽  
Vol 31 (5) ◽  
pp. no-no
Author(s):  
P. P. Purygin ◽  
I. S. Lipatov ◽  
I. A. Potapova ◽  
N. A. Yakimova ◽  
Yu. V. Tezikov ◽  
...  
Keyword(s):  
Sulfonic Acids ◽  
Cytoprotective Activity ◽  
Derivatives Of

Thallous Salts as Derivatives of Sulfonic Acids. II

1952 ◽  
Vol 74 (1) ◽  
pp. 264-266 ◽  
Author(s):  
Henry Gilman ◽  
H. Smith Broadbent
Keyword(s):  
Sulfonic Acids ◽  
Derivatives Of

scholarly journals Synthesis, Acaricidal, Bacteriostatic Activity Among the Amino Derivatives 5,7-Dichloro-4,6-Dinitrobenzofuroxana

2019 ◽  
Vol 8 (2) ◽  
pp. 11-15
Author(s):  
L. V. Spatlova
Keyword(s):  
Biological Activity ◽  
Amino Derivative ◽  
Bacteriostatic Activity ◽  
Hazard Class ◽  
Reaction Conditions ◽  
Low Concentrations ◽  
Wide Range ◽  
Amino Derivatives ◽  
New Compounds ◽  
Derivatives Of

Introduction. In recent years, interest in the compounds of the benzofuroxane series has increased, because they have a wide range of biological activity, and in addition are donors of nitric oxide. In the scientific literature, many works are related to the synthesis and study of the biological activity of 5-nitro-4,6-dichlorobenzofuroxane amino derivatives, whereas amino derivatives of the 5,7-dichlor-4,6-dinitrobenzofuroxane substrate have been poorly studied.Aim. Is the synthesis of new amino derivatives of 5,7-dichloro-4,6-dinitrobenzofuroxane and the study of their biological activity.Materials and methods. Investigated the reaction of condensation of 5,7-dichloro-4,6-dinitrobenzofuroxane with different aromatic amines, containing functional groups of acceptor character in their structure were selected. In order to increase the yield for each specific reaction, the reaction conditions were selected (the reaction temperature, medium, and the amount of amine). The structure of the compounds confirmed IR, NMR spectra and elemental analysis.Results and discussion. New compounds in the 5,7-diamino-4,6-dinitrobenzofuroxane series were obtained. Acute toxicity, acaricidal and bacteriostatic activity against Escherichia coli and Staphylococcus aureus were studied. The obtained compounds were found to have high pharmacological activity, superior to the comparison drug (Chlorophos and Creolin).Conclusion. Most of the amino derivative synthesized 5,7-dichloro-4,6-dinitrobenzofuroxane have a high activity against mites and bacteria. Compounds containing in their structure chlorine and methyl radicals, have biological activity at low concentrations, are low-toxic and belong to the 4th hazard class.

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