Synthesis and bactericidal activity of quaternary ammonium compounds containing an asymmetric nitrogen atom

1990 ◽  
Vol 24 (1) ◽  
pp. 47-51
Author(s):  
V. E. Limanov ◽  
N. V. Myazina ◽  
I. M. Tsivrova
Keyword(s):  
Nitrogen Atom ◽  
Bactericidal Activity ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Compounds ◽  
Asymmetric Nitrogen ◽  
Ammonium Compounds

scholarly journals Quaternary ammonium compounds. A new technique for the study of their bactericidal action and the results obtained with cetavlon (Cetyltrimethylammonium bromide)

1949 ◽  
Vol 47 (3) ◽  
pp. 271-277 ◽  
Author(s):  
G. E. Davies
Keyword(s):  
Organic Matter ◽  
Bactericidal Activity ◽  
Quaternary Ammonium ◽  
Cetyltrimethylammonium Bromide ◽  
Room Temperature ◽  
Quaternary Ammonium Compounds ◽  
Bactericidal Action ◽  
A New Technique ◽  
Suitable Technique ◽  
Ammonium Compounds

1. Some sources of error in the testing of quaternary ammonium compounds for bactericidal activity have been investigated. These resolve themselves into (a) errors caused by bacteriostasis, and (b) errors caused by the clumping of bacteria.2. A suitable technique, free from these errors, is described.3. Cetavlon in 0·1% solution is a powerful bactericide even in the presence of moderate amounts of organic matter.4. One per cent Cetavlon will not kill spores at room temperature even when contact is maintained for several days.5. Bacteria surviving the action of quaternary ammonium compounds retain their virulence.

Synthesis of acyclic quaternary ammonium compounds containing ω-alkoxyethyl and 2-hydroxyethyl substituents at the nitrogen atom

2015 ◽  
Vol 64 (11) ◽  
pp. 2697-2701 ◽  
Author(s):  
K. V. Tcarkova ◽  
S. K. Belus’ ◽  
O. I. Artyushin ◽  
A. V. Kharlamov ◽  
N. A. Bondarenko
Keyword(s):  
Nitrogen Atom ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Compounds ◽  
Ammonium Compounds

Determination of quaternary ammonium compounds in food products by the method of ultra-performance liquid chromatography/high resolution mass-spectrometry

2020 ◽  
Vol 86 (8) ◽  
pp. 23-31
Author(s):  
V. G. Amelin ◽  
D. S. Bolshakov
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Quaternary Ammonium ◽  
High Resolution Mass Spectrometry ◽  
Food Products ◽  
Quaternary Ammonium Compounds ◽  
High Resolution Mass ◽  
Ammonium Compounds ◽  
Resolution Mass

The goal of the study is developing a methodology for determination of the residual amounts of quaternary ammonium compounds (QAC) in food products by UHPLC/high-resolution mass spectrometry after water-acetonitrile extraction of the determined components from the analyzed samples. The identification and determination of QAC was carried out on an «UltiMate 3000» ultra-high-performance liquid chromatograph (Thermo Scientific, USA) equipped with a «maXis 4G» high-resolution quadrupole-time-of-flight mass spectrometric detector and an ion spray «ionBooster» source (Bruker Daltonics, Germany). Samples of milk, cheese (upper cortical layer), dumplings, pork, chicken skin and ground beef were used as working samples. Optimal conditions are specified for chromatographic separation of the mixture of five QAC, two of them being a mixture of homologues with a linear structure (including isomeric forms). The identification of QAC is carried out by the retention time, exact mass of the ions, and coincidence of the mSigma isotopic distribution. The limits for QAC detection are 0.1 – 0.5 ng/ml, the determination limits are 1 ng/ml for aqueous standard solutions. The determinable content of QAC in food products ranges within 1 – 100 ng/g. The results of analysis revealed the residual amount of QAC present in all samples, which confirms data of numerous sources of information about active use of QAC-based disinfectants in the meat and dairy industry. The correctness of the obtained results is verified by introduction of the additives in food products at a level of 10 ng/g for each QAC. The relative standard deviation of the analysis results does not exceed 0.18. The duration of the analysis is 30 – 40 min.

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