Estimation of the potential antitumor activity of chemical compounds according to the inhibition of dna synthesis in tumor cells, spleen, and small intestine of C3HA mice with ascites hepatoma 22A

1985 ◽  
Vol 19 (8) ◽  
pp. 526-532
Author(s):  
G. I. Potapova ◽  
N. O. Gudratov ◽  
T. P. Nedorezova ◽  
T. G. Nikolaeva
Keyword(s):  
Small Intestine ◽  
Antitumor Activity ◽  
Dna Synthesis ◽  
Tumor Cells ◽  
Chemical Compounds ◽  
Ascites Hepatoma ◽  
Hepatoma 22A ◽  
Inhibition Of Dna Synthesis ◽  
Ascites Hepatoma 22A ◽  
Potential Antitumor

Inhibition of DNA synthesis by a factor from ascites tumor cells

1977 ◽  
Vol 13 (10) ◽  
pp. 1195-1196 ◽  
Author(s):  
K. Rothbarth ◽  
G. Maier ◽  
E. Schöpf ◽  
D. Werner
Keyword(s):  
Dna Synthesis ◽  
Tumor Cells ◽  
Ascites Tumor ◽  
Inhibition Of Dna Synthesis

Induction of Cyclin E and Inhibition of DNA Synthesis by the Novel Acronycine Derivative S23906-1 Precede the Irreversible Arrest of Tumor Cells in S Phase Leading to Apoptosis

2001 ◽  
Vol 60 (6) ◽  
pp. 1383-1391 ◽  
Author(s):  
Stéphane Léonce ◽  
Valérie Pérez ◽  
Stéphanie Lambel ◽  
Delphine Peyroulan ◽  
François Tillequin ◽  
...  
Keyword(s):  
Dna Synthesis ◽  
Tumor Cells ◽  
Cyclin E ◽  
S Phase ◽  
The Novel ◽  
Inhibition Of Dna Synthesis

scholarly journals Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models

2020 ◽  
Vol 6 (3) ◽  
pp. FSOA442
Author(s):  
María V Giolito ◽  
Cristian M Camacho ◽  
Maitena Martinez-Amezaga ◽  
Carla I Traficante ◽  
Rocío A Giordano ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Tumor Cells ◽  
Anticancer Agents ◽  
Triple Negative ◽  
Chemical Compounds ◽  
Mammary Adenocarcinoma ◽  
Antitumor Action ◽  
Migratory Capacity ◽  
High Antitumor Activity

Aim: According to the need for the development of new anticancer agents, we have synthetized novel bioactive compounds and aimed to determine their antitumor action. Materials & methods: We describe in vitro studies evaluating the effect of 35 novel chemical compounds on two triple negative murine mammary adenocarcinoma tumors. Results & conclusion: Three compounds were selected because of their high antitumor activity and their low toxicity to normal cells. Their effect on tumor cells apoptosis, clonogenicity and migratory capacity, were determined. We found that the selected compounds showed inhibition of viability and clonogenic capacity, and promotion of apoptosis. They also decreased the migratory capacity of tumor cells. The results obtained suggest the likelihood of their future use as antitumor and/or antimetastatic agents.

4,5′-Dimethylangelicin, a New Very Active Monofunctional Furoeoumarin

1978 ◽  
Vol 33 (3-4) ◽  
pp. 296-298 ◽  
Author(s):  
F. Bordon ◽  
F. Baccichetti ◽  
F. Carlassare
Keyword(s):  
Dna Synthesis ◽  
Tumor Cells ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Strong Inhibition ◽  
Ehrlich Ascites ◽  
Cross Linkage ◽  
Inhibition Of Dna Synthesis ◽  
Very High

4,5′-dimethylangelicin is a new angular furocoumarin that by irradiation at 365 nm shows a very high photo­ reactivity towards DNA in vivo, without forming any cross-linkage; by photosensitization of Ehrlich ascites tumor cells a strong inhibition of DNA synthesis was observed.

Effect of gangliosides secreted by ascites hepatoma 22a cells on intensity of protein synthesis in these cells and on their sensitivity to indocarb

1982 ◽  
Vol 94 (4) ◽  
pp. 1419-1422
Author(s):  
G. I. Shaposhnikova ◽  
N. D. Zvezdina ◽  
L. A. Mal'chenko ◽  
N. A. Teplits ◽  
N. V. Prokazova ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Ascites Hepatoma ◽  
Hepatoma 22A ◽  
Ascites Hepatoma 22A
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