Amine oxidase activity of ceruloplasmin and copper (II) complexes with derivatives of anthranilic acid

1980 ◽  
Vol 14 (8) ◽  
pp. 509-514
Author(s):  
A. S. Grigor'eva ◽  
E. E. Kriss ◽  
N. F. Konakhovich
Keyword(s):  
Anthranilic Acid ◽  
Oxidase Activity ◽  
Amine Oxidase ◽  
Derivatives Of ◽  
Amine Oxidase Activity

THE EFFECT OF AMINE OXIDASE INHIBITORS ON PREGNANCY

1963 ◽  
Vol 27 (2) ◽  
pp. 147-155 ◽  
Author(s):  
EVELYN POULSON ◽  
J. M. ROBSON
Keyword(s):  
Early Pregnancy ◽  
Oxidase Activity ◽  
Chemical Structure ◽  
Amine Oxidase ◽  
The Other ◽  
Toxic Effects ◽  
Luteal Function ◽  
Hormonal Mechanism ◽  
Derivatives Of ◽  
Amine Oxidase Activity

SUMMARY The effects of seven amine oxidase inhibitors on pregnancy were investigated in mice. Four of the compounds were derivatives of hydrazine and three were not. All the derivatives of hydrazine and one of the other compounds tested produced toxic effects in early pregnancy but were relatively inactive later. The effect of one of the compounds investigated (HP 1325) was, to a great extent, reversed by either progesterone or prolactin, suggesting an interference with the hormonal mechanism responsible for the maintenance of pregnancy. HP 1325 (and 5-hydroxytryptamine) did not interrupt pseudopregnancy, indicating that luteal function is not completely inhibited. Evidence is adduced that the effects on pregnancy are not related to any particular chemical structure or to the amine-oxidase activity of the compound tested.

Mitochondrial Oxidation of p-N, N-Dimethylamino-β-Phenethylamine (DAPA)

1975 ◽  
Vol 33 ◽  
pp. 458-459
Author(s):  
W. Allen Shannon ◽  
Hannah L. Wasserkrug ◽  
andArnold M. Seligman
Keyword(s):  
Guinea Pig ◽  
Oxidase Activity ◽  
Amine Oxidase ◽  
Histochemical Demonstration ◽  
Guinea Pig Heart ◽  
Pig Kidney ◽  
Cytoplasmic Vacuoles ◽  
Liver And Kidney ◽  
Mitochondrial Oxidation ◽  
Amine Oxidase Activity

The synthesis of a new substrate, p-N,N-dimethylamino-β-phenethylamine (DAPA)3 (Fig. 1) (1,2), and the testing of it as a possible substrate for tissue amine oxidase activity have resulted in the ultracytochemical localization of enzyme oxidase activity referred to as DAPA oxidase (DAPAO). DAPA was designed with the goal of providing an amine that would yield on oxidation a stronger reducing aldehyde than does tryptamine in the histochemical demonstration of monoamine oxidase (MAO) with tetrazolium salts.Ultracytochemical preparations of guinea pig heart, liver and kidney and rat heart and liver were studied. Guinea pig kidney, known to exhibit high levels of MAO, appeared the most reactive of the tissues studied. DAPAO reaction product appears primarily in mitochondrial outer compartments and cristae (Figs. 2-4). Reaction product is also localized in endoplasmic reticulum, cytoplasmic vacuoles and nuclear envelopes (Figs. 2 and 3) and in the sarcoplasmic reticulum of heart.

Acrolein produced from polyamines as one of the uraemic toxins

2003 ◽  
Vol 31 (2) ◽  
pp. 371-374 ◽  
Author(s):  
K. Sakata ◽  
K. Kashiwagi ◽  
S. Sharmin ◽  
S. Ueda ◽  
K. Igarashi
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Oxidase Activity ◽  
Culture Medium ◽  
Cellular Proliferation ◽  
Amine Oxidase ◽  
Early Stage ◽  
Chronic Glomerulonephritis ◽  
Toxic Compound ◽  
Amine Oxidase Activity

It is well known that the addition of spermine or spermidine to culture medium containing ruminant serum inhibits cellular proliferation. This effect is caused by the products of oxidation of polyamines that are generated by serum amine oxidase. Among the products, we found that acrolein is a major toxic compound produced from spermine and spermidine by amine oxidase. We then analysed the level of polyamines (putrescine, spermidine and spermine) and amine oxidase activity in plasma of patients with chronic renal failure. It was found that the levels of putrescine and the amine oxidase activity were increased, whereas spermidine and spermine were decreased in plasma of patients with chronic renal failure. The levels of free and protein-conjugated acrolein were also increased in plasma of patients with chronic renal failure. An increase in putrescine, amine oxidase and acrolein in plasma was observed in all cases such as diabetic nephropathy, chronic glomerulonephritis and nephrosclerosis. These results suggest that acrolein is produced during the early stage of nephritis through kidney damage and also during uraemia through accumulation of polyamines in blood due to the decrease in their excretion into urine.

scholarly journals Renalase Prevents AKI Independent of Amine Oxidase Activity

2014 ◽  
Vol 25 (6) ◽  
pp. 1226-1235 ◽  
Author(s):  
Ling Wang ◽  
Heino Velazquez ◽  
Gilbert Moeckel ◽  
John Chang ◽  
Ahrom Ham ◽  
...  
Keyword(s):  
Oxidase Activity ◽  
Amine Oxidase ◽  
Amine Oxidase Activity

scholarly journals Cytotoxicity of spergualin and amine oxidase activity in medium.

1985 ◽  
Vol 38 (7) ◽  
pp. 899-903 ◽  
Author(s):  
SETSUKO KUNIMOTO ◽  
KEIKO MIURA ◽  
HIRONOBU IINUMA ◽  
TOMIO TAKEUCHI ◽  
HAMAO UMEZAWA
Keyword(s):  
Oxidase Activity ◽  
Amine Oxidase ◽  
Amine Oxidase Activity
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