Effect of pyridoxal phosphate on the narcotic action, toxicity, and metabolism of hexenal

1981 ◽  
Vol 15 (5) ◽  
pp. 303-306
Author(s):  
V. Yu. Ostrovskii ◽  
M. I. Bushma ◽  
�. I. Parkhovchenko ◽  
P. I. Lukienko
Keyword(s):  
Pyridoxal Phosphate ◽  
Narcotic Action

A Class of Drugs that Inhibits Platelet Release and Aggregation by Apparent Interference with Anion Transport

1979 ◽  
Author(s):  
N.R. Shulman ◽  
H.B. Pollard ◽  
K. Tack-Goldman
Keyword(s):  
Pyridoxal Phosphate ◽  
Human Platelets ◽  
Anion Transport ◽  
Serotonin Release ◽  
Secretory Cells ◽  
Chloride Uptake ◽  
Potential Alternative ◽  
Osmotic Lysis ◽  
Platelet Release ◽  
Ph Range

The platelet release reaction is analogous to the process of exocytosis by which many other secretory cells release hormones or mediators from intracellular granules. Anion transport blocking (ATB) drugs Inhibit release of epinephrine from isolated chromaffin granules (CG) by blocking chloride uptake and preventing osmotic lysis. Studies on platelets analagous to those done on CG showed that increasing osmotic strength in the range 600-1000 m0sm progressively suppressed serotonin release to completion and that ATB drugs (viz, probenecid, SITS, pyridoxal phosphate and suramin) at mM concentrations completely inhibited release and aggregation of human platelets stimulated by thrombin, ADP, A23187, epinephrine or collagen. Sulfinpyrazone has the appropriate structure for anionic blocking, and may suppress platelet function as effectively by this mechanism as by cycloxy-genase inhibition. The ATB drugs acted apparently to prevent movement of OH- from the more alkaline medium into the relatively acidic granule, for platelet release was not inhibited by replacing anions with isethionate or sucrose, but was markedly dependent on OH- in the pH range 6 to 7.5 where inhibition by the ATB drugs was competitive with respect to OH-. Since the ATB compounds include some relatively nontoxic drugs in common use, and since their action on platelets differs markedly from that of aspirin, they should receive attention as potential alternative or auxiliary antithrombotic agents.

scholarly journals A role for pyridoxal phosphate in the control of dephosphorylation of phosphorylase a.

1979 ◽  
Vol 254 (17) ◽  
pp. 8263-8269
Author(s):  
S.C. Yan ◽  
R.J. Uhing ◽  
R.F. Parrish ◽  
D.E. Metzler ◽  
D.J. Graves
Keyword(s):  
Pyridoxal Phosphate

scholarly journals The Affinity of Carboplatin to B-Vitamins and Nucleobases

2021 ◽  
Vol 22 (7) ◽  
pp. 3634
Author(s):  
Beata Szefler ◽  
Przemysław Czeleń ◽  
Przemysław Krawczyk
Keyword(s):  
Vitamin B6 ◽  
Pyridoxal Phosphate ◽  
Antitumor Agents ◽  
Lone Pair ◽  
Chemical Compounds ◽  
Free Energies ◽  
Aromatic Rings ◽  
Anti Cancer ◽  
Potential Impact ◽  
Reactive Molecule

Platinum compounds have found wide application in the treatment of various types of cancer and carboplatin is one of the main platinum-based drugs used as antitumor agents. The anticancer activity of carboplatin arises from interacting with DNA and inducing programmed cell death. However, such interactions may occur with other chemical compounds, such as vitamins containing aromatic rings with lone-pair orbitals, which reduces the anti-cancer effect of carboplatin. The most important aspect of the conducted research was related to the evaluation of carboplatin affinity to vitamins from the B group and the potential impact of such interactions on the reduction of therapeutic capabilities of carboplatin in anticancer therapy. Realized computations, including estimation of Gibbs Free Energies, allowed for the identification of the most reactive molecule, namely vitamin B6 (pyridoxal phosphate). In this case, the computational estimations indicating carboplatin reactivity were confirmed by spectrophotometric measurements.

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