Effects of mepregenol 17-monoacetate on the gonadotropic activity of the pituitary and fertility

1983 ◽  
Vol 17 (10) ◽  
pp. 735-737
Author(s):  
G. M. Kadatskii ◽  
G. S. Grinenko ◽  
G. V. Nikitina ◽  
V. V. Korkhov ◽  
K. V. Demidov
1975 ◽  
Vol 21 (2) ◽  
pp. 463-469 ◽  
Author(s):  
Paul Sroka ◽  
Robert H. Barth ◽  
Lawrence I. Gilbert ◽  
Gerardus B. Staal

Author(s):  
V. G. Baranov ◽  
O. N. Savchenko ◽  
M. V. Propp ◽  
O. A. Danilova ◽  
L. N. Maslova ◽  
...  

BMJ ◽  
1938 ◽  
Vol 1 (4037) ◽  
pp. 1094-1097 ◽  
Author(s):  
W. R. Henderson ◽  
I. W. Rowlands

1939 ◽  
Vol 1939 (1) ◽  
pp. 340-341 ◽  
Author(s):  
A. Nalbandov ◽  
L. E. Casida

1962 ◽  
Vol 202 (3) ◽  
pp. 387-391 ◽  
Author(s):  
Karl M. Knigge

Pituitary glands of neonatal rats were implanted by stereotaxic methods in various hypothalamic areas of the brains of adult, hypophysectomized male rats. Of 58 implantations, 44 viable grafts composed of pars distalis, intermedia, and epithelioid-like nervosa were found 3 months later. In none of the graft-bearing animals was there any evidence of thyrotropic or corticotropic activity as judged by thyroid or adrenal weight, I131 uptake, or plasma free corticosteroids. In 18 graft-bearing animals, testicular weights ranged from 831 to 2,118 mg, compared to mean testis weight of 165 mg for hypophysectomized, nonimplanted animals. Histological sections of testes from these graft-bearing animals revealed active spermatogenesis. In each implanted animal with testicular maintenance, the pituitary graft was situated in the floor of the hypothalamus, encroaching upon or interrupting fibers of the supraopticohypophyseal tract. Adenohypophyseal cells which appeared to be nearest or more intimately related to these fibers were large (12–20µ), vacuolated, and contained abundant fuchsinophilic granules typical of castration cells. Other chromophil types were not present. In all nonfunctional grafts (situated in preoptic area, septum, anterior hypothalamus, and mammillary region) adenohypophyseal cells were uniformly small and chromophobic.


1938 ◽  
Vol 124 (837) ◽  
pp. 492-503 ◽  

In examining the interaction of a large number of gonadotropic extracts and antigonadotropic sera (Rowlands 1937), two cases were observed where the serum of animals chronically injected with gonadotropic extracts had the effect, not of inhibiting, but of augmenting the action of the corresponding extract on test rats. This effect was produced by the serum of a sheep which had received a course of injections with extract of sheep pituitary, and by that of a goat receiving pig pituitary extract. Collip (1937) has shown that the serum of sheep injected with sheep pituitary extract augments the action of the injected extract in test rats. A similar result was obtained by Thompson (1937 a ), who found that the serum of dogs and a horse after injection of extracts of sheep pituitary showed temporary pro-gonadotropic activity. One of the explanations suggested by Thompson was based on the possibility that the gonadotropic antagonist (Evans and others 1936; Freud 1937) is antigenic, and that the augmenting sera contain a predominance of antibody against the antagonist.


Sign in / Sign up

Export Citation Format

Share Document