Preparation and characteristics of an immunosorbent for purifying human somatotrophic hormone

1986 ◽  
Vol 20 (11) ◽  
pp. 782-785
Author(s):  
G. A. Popkova ◽  
I. S. Khromov ◽  
L. V. Stroeva ◽  
O. F. Salova ◽  
R. A. Al'tshuler ◽  
...  
Keyword(s):  
Somatotrophic Hormone

GROWTH INHIBITION OF SARCOMA 180 BY HORMONE ANTISERA AND 5-FLUOROURACIL

1963 ◽  
Vol 42 (3) ◽  
pp. 453-464 ◽  
Author(s):  
Ludwik Anigstein ◽  
Dorothy M. Anigstein ◽  
Edward G. Rennels
Keyword(s):  
Growth Inhibition ◽  
Experimental Animal ◽  
Inhibitory Action ◽  
Tumour Growth ◽  
Inhibitory Effect ◽  
Sarcoma 180 ◽  
Swiss Mice ◽  
Somatotrophic Hormone

ABSTRACT Somatotrophic hormone antisera (STHAS) were prepared by the immunization of rabbits with purified bovine or human STH. The capacity of these antiserum preparations to inhibit the growth of experimental animal tumours was tested by giving daily injections to young Swiss mice bearing implants of Sarcoma 180. A significant inhibitory action of both bovine and human STHAS on the growth of Sarcoma 180 tumours was shown. This inhibitory effect was more marked in mice which had been inoculated at birth with the antiserum which was later injected during the period of tumour growth. The use of somatotrophic hormone antiserum treatment in combination with 5-fluorouracil proved to be somewhat more effective than the 5-FU alone. It was concluded that somatotrophic hormone antiserum offers promise as a tumour inhibitory agent and as adjuvant in carcino-therapy.

THE COMBINED EFFECT OF MONOAMINE OXIDASE INHIBITORS AND CORTICOSTEROIDS ON THE PITUITARY-GONADAL SYSTEM OF MALE RATS

1966 ◽  
Vol 35 (3) ◽  
pp. 217-222 ◽  
Author(s):  
U. ZOR ◽  
H. AILABOUNI ◽  
F. G. SULMAN
Keyword(s):  
Monoamine Oxidase ◽  
Combined Treatment ◽  
Prostate Gland ◽  
Thyroid Stimulating Hormone ◽  
Monoamine Oxidase Inhibitors ◽  
Male Rats ◽  
Ovariectomized Rats ◽  
Accessory Sex Glands ◽  
Somatotrophic Hormone ◽  
Intact Rats

SUMMARY The mechanism by which combined treatment with monoamine oxidase inhibitors and a corticosteroid reduces the weight of the accessory sex glands in intact rats by about one half has been studied. Phenelzine sulphate in combination with hydrocortisone acetate given for 30 days to ovariectomized rats reduced the pituitary stores of luteinizing hormone (LH) by 33%. Similar reductions in somatotrophic hormone, corticotrophin and thyroid-stimulating hormone content were found after comparable treatment, whereas luteotrophic hormone increased. The increase of weight of the seminal vesicles and prostate gland produced by human chorionic gonadotrophin could be partly antagonized by the simultaneous administration of mebanazine and dexamethasone, but the action of testosterone on these glands in castrated animals was not inhibited. Interference with the production and effectiveness of LH is therefore the most likely mode of action by which these drugs effect the reduction of the weight of the accessory sex glands.

The Effect of Cortisone and Somatotrophic Hormone on Vaccinia Virus Lesions and Benzyl Alcohol Toxicity in the Embryonated Egg

1954 ◽  
Vol 95 (2) ◽  
pp. 160-164 ◽  
Author(s):  
G. H. Scherr ◽  
J. M. Severens ◽  
P. Jurtshuk ◽  
C. L. Wittenberger
Keyword(s):  
Vaccinia Virus ◽  
Benzyl Alcohol ◽  
Somatotrophic Hormone

SOMATOTROPHIC HORMONE AND THE PANCREAS

The Lancet ◽  
1953 ◽  
Vol 262 (6798) ◽  
pp. 1265-1266 ◽  
Author(s):  
Cesare Cavallero
Keyword(s):  
Somatotrophic Hormone

Production of diabetes insipidus in hypophysectomized rats by hypothalamic lesions

1961 ◽  
Vol 201 (5) ◽  
pp. 811-814 ◽  
Author(s):  
C. C. Gale ◽  
S. Taleisnik ◽  
S. M. McCann
Keyword(s):  
Diabetes Insipidus ◽  
Water Intake ◽  
Median Eminence ◽  
Urine Volume ◽  
Water Turnover ◽  
Hypothalamic Lesions ◽  
Significant Augmentation ◽  
Hypophysectomized Rats ◽  
Somatotrophic Hormone ◽  
Made In

Lesions in the median eminence produced permanent diabetes insipidus (DI) in chronically hypophysectomized rats. Water turnover in these animals, however, was only about half of that observed when lesions were made in rats with intact pituitaries and was further characterized by absence of the normal interphase. Conversely, when hypophysectomy was performed in rats with DI, an immediate and sustained 50% reduction in water intake occurred. Administration of adrenocorticotropin to hypophysectomized rats with lesions caused significant augmentation of DI, but not to levels found in rats with DI and intact pituitaries. Neither somatotrophic hormone (STH) nor triiodothyronine increased water turnover when given to hypophysectomized animals with DI. Lesions in the median eminence of hypophysectomized rats induced an immediate increase in urine volume in the absence of water intake, which indicates that primary polyuria was responsible at least in part for the development of DI in hypophysectomized rats with lesions.

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