Synthesis and antiphlogistic activity of protected glycopeptides of glycyrrhizic acid

1988 ◽  
Vol 22 (6) ◽  
pp. 460-462 ◽  
Author(s):  
L. A. Baltina ◽  
V. A. Davydova ◽  
I. G. Chikaeva ◽  
R. M. Shayakhmetova ◽  
A. P. Kapina ◽  
...  
Keyword(s):  
Glycyrrhizic Acid ◽  
Antiphlogistic Activity

Research Progress of Glycyrrhizic Acid on Antiviral Activity

2019 ◽  
Vol 19 (10) ◽  
pp. 826-832 ◽  
Author(s):  
Zhi-Gang Sun ◽  
Ting-Ting Zhao ◽  
Na Lu ◽  
Yong-An Yang ◽  
Hai-Liang Zhu
Keyword(s):  
Hepatitis B ◽  
Glycyrrhizic Acid ◽  
Skin Diseases ◽  
Hepatitis B Surface Antigen ◽  
Research Progress ◽  
Extracellular Secretion ◽  
Antiviral Effects ◽  
B Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

Glycyrrhizic acid (GA), a triterpene isolated from the roots and rhizomes of licorice, named Glycyrrhiza glabra, is the principal bioactive ingredient of anti-viral, anti-inflammatory and hepatoprotective effects. GA has been used in the clinical treatment of hepatitis, bronchitis, gastric ulcer, AIDS (acquired immunodeficiency syndrome), certain cancers and skin diseases. It has a direct effect on anti-HBV (hepatitis B virus) via affecting the HBsAg (hepatitis B surface antigen) to extracellular secretion, improving liver dysfunction in patients with chronic hepatitis B, and ultimately improving the immune status of HBV. GA can significantly inhibit the proliferation of HIV, showing an immune activation. The clinical application of GA on the prevention and treatments of various diseases may derive from its numerous pharmacological properties. This review provides the summary of the antiviral effects of GA on research progress and mechanism in recent years.

Antiviral activity of glycyrrhizic acid conjugates with amino acid esters against Zika virus

2021 ◽  
Vol 294 ◽  
pp. 198290
Author(s):  
Lidia A. Baltina ◽  
Mann-Jen Hour ◽  
Ya-Chi Liu ◽  
Young-Sheng Chang ◽  
Su-Hua Huang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Antiviral Activity ◽  
Zika Virus ◽  
Glycyrrhizic Acid ◽  
Amino Acid Esters ◽  
Acid Esters

scholarly journals Acute Renal Failure Following Hypokalemic Rhabdomyolysis due to Chronic Glycyrrhizic Acid Administration.

1992 ◽  
Vol 31 (5) ◽  
pp. 708-711 ◽  
Author(s):  
Akihiko CHUBACHI ◽  
Hideki WAKUI ◽  
Ken-ichi ASAKURA ◽  
Shigeki NISHIMURA ◽  
Yasushi NAKAMOTO ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Glycyrrhizic Acid ◽  
Acid Administration

scholarly journals Anti-Inflammatory Activities of Licorice Extract and Its Active Compounds, Glycyrrhizic Acid, Liquiritin and Liquiritigenin, in BV2 Cells and Mice Liver

Molecules ◽  
2015 ◽  
Vol 20 (7) ◽  
pp. 13041-13054 ◽  
Author(s):  
Ji-Yeon Yu ◽  
Jae Ha ◽  
Kyung-Mi Kim ◽  
Young-Suk Jung ◽  
Jae-Chul Jung ◽  
...  
Keyword(s):  
Glycyrrhizic Acid ◽  
Active Compounds ◽  
Bv2 Cells ◽  
Licorice Extract ◽  
Anti Inflammatory ◽  
Mice Liver

Glycyrrhizic acid: the assessment of a no effect level

2000 ◽  
Vol 19 (8) ◽  
pp. 434-439 ◽  
Author(s):  
C E M van Gelderen ◽  
J A Bijlsma ◽  
W van Dokkum ◽  
T J F Savelkoull
Keyword(s):  
Body Weight ◽  
Pilot Study ◽  
Glycyrrhizic Acid ◽  
Mild Hypertension ◽  
Daily Intake ◽  
Long Term Effects ◽  
Healthy Female ◽  
The Usa ◽  
Effect Level

Because from earlier experiments in rats and a pilot study in humans a no effect level of glycyrrhizic acid could not be established, a second experiment was performed in healthy volunteers. The experiment was performed in females only, because the effects were most marked in females in the pilot study. Doses of 0, 1, 2 and 4 mg glycyrrhizic acid/kg body weight were administered orally for 8 weeks to 39 healthy female volunteers aged 19-40 years. The experimentlasted 12 weeks including an adaptation and a “wash-out” period.Ano-effectlevel of2 mg/kgis proposed from the results ofthis study, from which an acceptable daily intake (ADI) of 0.2 mg/kg body weight can be extrapolated with a safety factor of 10. This means consumption of 12 mg glycyrrhizic acid/day for a person with a body weight of 60 kg. This would be equal to 6 g licorice a day, assuming that licorice contains 0.2% of glycyrrhizic acid. The proposed ADI is below the limit advised by the Dutch Nutrition Council of 200 mg glycyrrhizic acid/day. This reflects the relatively mild acute toxicity of glycyrrhizic acid, which is also emphasised by the “generally recognised as safe” (GRAS) status of glycyrrhizic acid in the USA in 1983. However, the long-term effects of a mild chronic intoxication (causing, for example, a mild hypertension), although not immediately lethal, justify special attention to the amount of glycyrrhizic acid used daily.

Effect of glycyrrhizic acid on hemolysis of red blood cells and properties of cell membranes

2014 ◽  
Vol 63 (5) ◽  
pp. 1201-1204 ◽  
Author(s):  
O. Yu. Selyutina ◽  
N. E. Polyakov ◽  
D. V. Korneev ◽  
B. N. Zaitsev
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Cell Membranes ◽  
Glycyrrhizic Acid
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