Anticholinesterase activity of monoquaternary ammonium salts containing hydrophobic radicals

1988 ◽  
Vol 22 (6) ◽  
pp. 452-456
Author(s):  
I. I. Bityukova ◽  
N. D. Igumnova ◽  
N. V. Klimova ◽  
V. M. Solov'ev ◽  
A. P. Skoldinov ◽  
...  
Keyword(s):  
Ammonium Salts ◽  
Anticholinesterase Activity ◽  
Monoquaternary Ammonium

ChemInform Abstract: Anticholinesterase Activity of Mono-Quaternary Ammonium Salts Containing Hydrophobic Residues.

ChemInform ◽  
1988 ◽  
Vol 19 (49) ◽  
Author(s):  
I. I. BITYUKOVA ◽  
N. D. IGUMNOVA ◽  
N. V. KLIMOVA ◽  
V. M. SOLOV'EV ◽  
A. P. SKOLDINOV ◽  
...  
Keyword(s):  
Quaternary Ammonium ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
Anticholinesterase Activity ◽  
Hydrophobic Residues

The wide-spectrum antimicrobial effect of novel N-alkyl monoquaternary ammonium salts and their mixtures; the QSAR study against bacteria

2020 ◽  
Vol 206 ◽  
pp. 112584 ◽  
Author(s):  
Ondrej Soukup ◽  
Marketa Benkova ◽  
Rafael Dolezal ◽  
Radek Sleha ◽  
David Malinak ◽  
...  
Keyword(s):  
Wide Spectrum ◽  
Antimicrobial Effect ◽  
Ammonium Salts ◽  
Qsar Study ◽  
Monoquaternary Ammonium

Thin-layer chromatography on cellulose. Monoquaternary ammonium salts

1981 ◽  
Vol 15 (9) ◽  
pp. 687-688
Author(s):  
N. S. Volkova ◽  
T. B. Primakova ◽  
S. D. Sokolov
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Ammonium Salts ◽  
Layer Chromatography ◽  
Monoquaternary Ammonium

scholarly journals Enantioselective aza-Michael Cyclization Reaction Catalyzed by Quinine-Derived Monoquaternary Ammonium Salts: an Effective Route to Synthesize Letermovir

2021 ◽  
Vol 03 (04) ◽  
pp. e194-e199
Author(s):  
Liang Chen ◽  
Wei-Yuan Liu ◽  
Si-Ju Bi ◽  
Ting Zhou ◽  
Jing Pan ◽  
...  
Keyword(s):  
Quaternary Ammonium ◽  
Large Scale ◽  
Lower Cost ◽  
Phase Transfer ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
Phase Transfer Catalysts ◽  
Large Scale Preparation ◽  
Scale Preparation ◽  
Monoquaternary Ammonium

A series of mono- or bis-quaternary ammonium salts derived from cinchonidine or quinine was synthesized and screened as potent phase-transfer catalysts for the reaction of aza-Michael cyclization, the key step in the synthesis of letermovir. During the reaction of aza-Michael cyclization, the screened monoquaternary ammonium salt quinine derivative Q1 transferred 7 to 8 with 91.9% yield and 58% ee. The application of Q1 was preferred, due to its enantioselectivity, the possibility of reuse, and the lower cost in large-scale preparation. Furthermore, the racemization condition of letermovir enantiomer was also explored for the possibility to develop the resolution/racemization process. With the optimal catalyst Q1 in hand, the synthesis of letermovir may be more convenient and economical in the future.

Access to Fe(II) Bis(σ-B-H) Aminoborane Complexes via Protonation of a Borohydride Complex and Dehydrogenation of Amine-Boranes

2019 ◽  
Author(s):  
Nikolaus Gorgas ◽  
Berthold Stöger ◽  
Luis F. Veiros ◽  
Karl Kirchner
Keyword(s):  
Structural Characterization ◽  
Ammonium Salts ◽  
Iron Based ◽  
Amine Boranes

We report on the first synthesis and structural characterization of the iron based aminoborane complexes. These species are formed upon protonation of a borohydride complex by ammonium salts.<br>

Аnticholinesterase and antioxidant activity of new binary conjugates of (с)-carbolines

2019 ◽  
Vol 484 (1) ◽  
pp. 104-108
Author(s):  
G. F. Makhaeva ◽  
E. F. Shevtsova ◽  
N. P. Boltneva ◽  
N. V. Kovaleva ◽  
E. V. Rudakova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Antioxidant Activity ◽  
Anticholinesterase Activity ◽  
Amyloid Aggregation ◽  
Varying Length ◽  
Β Amyloid ◽  
New Compounds

This study presents the synthesis of binary tetrohydro-γ-carbolines with ditriazol spacers of varying length, which exhibit anticholinesterase and antioxidant activity, as compared to the original Dimebon prototype. Anticholinesterase activity suggests the potential ability of the new compounds to block β-amyloid aggregation induced by anticholinesterase, making them promising candidates for further research preparations for the treatment of Alzheimer's disease. Particular attention should be paid to the conjugate with an intertriazol hexamethylene spacer, which can be regarded as the leading compound in this series.

New Bisquaternary Isoquinolinium Inhibitors of Brain Cholinesterases - Synthesis and Anticholinesterase Activity

2010 ◽  
Vol 7 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Jiri Binder ◽  
Martin Paar ◽  
Daniel Jun ◽  
Miroslav Pohanka ◽  
Martina Hrabinova ◽  
...  
Keyword(s):  
Anticholinesterase Activity
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