Effect of toremifene on the growth, hormone receptors and insulin-like growth factor-1 of hormone-dependent MCF-7 tumors in athymic mice

1993 ◽  
Vol 32 (5) ◽  
pp. 353-358 ◽  
Author(s):  
Yuchi Iino ◽  
Yoshiki Takai ◽  
Tatsumasa Ando ◽  
Noritaka Sugamata ◽  
Michio Maemura ◽  
...  
Endocrinology ◽  
1992 ◽  
Vol 130 (5) ◽  
pp. 2513-2520 ◽  
Author(s):  
J L Elliott ◽  
J M Oldham ◽  
G R Ambler ◽  
J J Bass ◽  
G S Spencer ◽  
...  

2010 ◽  
Vol 45 (8) ◽  
pp. 925-931 ◽  
Author(s):  
Augusto Schneider ◽  
Luiz Francisco Machado Pfeifer ◽  
Lucas Teixeira Hax ◽  
Giane Regina Paludo ◽  
Francisco Augusto Burkert Del Pino ◽  
...  

The objective of this study was to evaluate the plasma concentrations of insulin-like growth factor-I (IGF-I), and the mRNA hepatic expression of IGF-I and of the growth hormone receptors GHR and GHR 1A, in postpartum beef cows. Four Angus and four crossbred (Angus x Nelore) postpartum suckled beef cows were used. Liver and blood samples were collected every 10 days, from calving to 40 days postpartum, for gene expression and for β-hydroxybutyrate and IGF-I assays, respectively. Samples for progesterone assay were collected every other day, from day 10 to 40 postpartum. Three cows ovulated before 40 days postpartum. IGF-I concentration was higher in Angus x Nelore than in Angus cows. There was no difference in the expression of GHR, GHR 1A and IGF-I according to breed or ovulatory status. IGF-I concentrations were higher in crossbred cows, but have not changed according to postpartum ovulatory status. Moreover, changes in postpartum IGF-I concentrations are not associated with changes in liver GHR, GHR 1A and IGF-I mRNA expression in either breed.


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