Mucin immunohistochemistry of the columnar epithelium of the oesophagus (Barrett's oesophagus)

1989 ◽  
Vol 414 (4) ◽  
pp. 359-363 ◽  
Author(s):  
V. Duchatelle ◽  
F. Potet ◽  
J. Bara ◽  
J. Ma ◽  
D. Goldfain
Keyword(s):  
Barrett’S Oesophagus ◽  
Columnar Epithelium ◽  
Barrett's Oesophagus ◽  
Mucin Immunohistochemistry

3 Barrett's oesophagus or columnar epithelium of the lower oesophagus

1987 ◽  
Vol 1 (4) ◽  
pp. 769-789 ◽  
Author(s):  
Philippe Monnier ◽  
Charlotte Fontolliet ◽  
Marcel Savary ◽  
Jean-Baptiste Ollyo
Keyword(s):  
Barrett’S Oesophagus ◽  
Columnar Epithelium ◽  
Barrett's Oesophagus ◽  
Lower Oesophagus

scholarly journals Evolution of oesophageal adenocarcinoma from metaplastic columnar epithelium without goblet cells in Barrett's oesophagus

Gut ◽  
2015 ◽  
Vol 65 (6) ◽  
pp. 907-913 ◽  
Author(s):  
Danielle L Lavery ◽  
Pierre Martinez ◽  
Laura J Gay ◽  
Biancastella Cereser ◽  
Marco R Novelli ◽  
...  
Keyword(s):  
Goblet Cells ◽  
Barrett’S Oesophagus ◽  
Oesophageal Adenocarcinoma ◽  
Columnar Epithelium ◽  
Barrett's Oesophagus

Modelling Barrett's oesophagus

2010 ◽  
Vol 38 (2) ◽  
pp. 321-326 ◽  
Author(s):  
Jianping Kong ◽  
Douglas B. Stairs ◽  
John P. Lynch
Keyword(s):  
Gene Expression ◽  
Transcription Factors ◽  
Epithelial Cells ◽  
Expression Patterns ◽  
Dominant Negative ◽  
Barrett’S Oesophagus ◽  
Columnar Epithelium ◽  
Gene Expression Patterns ◽  
Barrett's Oesophagus ◽  
Normal Oesophagus

Barrett's oesophagus is the replacement of normal squamous oesophageal epithelium with an intestinalized columnar epithelium. Although some insight has been gained as to what Barrett's oesophagus is, how this columnar epithelium emerges from within a stratified squamous epithelium remains an unanswered question. We have sought to determine whether oesophageal keratinocytes can be trans-differentiated into Barrett's oesophagus cells. Using an Affymetrix microarray, we found unexpectedly that gene-expression patterns in the Barrett's oesophagus were only slightly more similar to the normal small intestine than they were to the normal oesophagus. Thus gene-expression patterns suggest significant molecular similarities remain between Barrett's oesophagus cells and normal squamous oesophageal epithelium, despite their histological resemblance with intestine. We next determined whether directed expression of intestine-specific transcription factors could induce intestinalization of keratinocytes. Retroviral-mediated Cdx2 (Caudal-type homeobox 2) expression in immortalized human oesophageal keratinocytes engineered with human telomerase reverse transcriptase (EPC2-hTERT cells) could be established transiently, but not maintained, and was associated with a reduction in cell proliferation. Co-expression of cyclin D1 rescued proliferation in the Cdx2-expressing cells, but co-expression of dominant-negative p53 did not. Cdx2 expression in the EPC2-hTERT.D1 cells did not induce intestinalization. However, when combined with treatments that induce chromatin remodelling, there was a significant induction of Barrett's oesophagus-associated genes. Studies are ongoing to determine whether other intestinal transcription factors, either alone or in combination, can provoke greater intestinalization of oesophageal keratinocytes. We conclude that, on the basis of gene-expression patterns, Barrett's oesophagus epithelial cells may represent an intermediate between oesophageal keratinocytes and intestinal epithelial cells. Moreover, our findings suggest that it may be possible to induce Barrett's oesophagus epithelial cells from oesophageal keratinocytes by altering the expression of certain critical genes.

Human and murine data suggest critical role for TGF-β in the aetiopathogenesis of Barrett's oesophagus

2001 ◽  
Vol 120 (5) ◽  
pp. A415-A415
Author(s):  
R FITZGERALD ◽  
B ONWUEGBUSI ◽  
G DEPAULO ◽  
R FEAKINS ◽  
L MCKINNEY ◽  
...  
Keyword(s):  
Critical Role ◽  
Barrett’S Oesophagus ◽  
Barrett's Oesophagus

ENDOSCOPIC RESECTION OF LOW GRADE DYSPLASIA IN BARRETT’S OESOPHAGUS: A RETROSPECTIVE STUDY ABOUT 61 PATIENTS

2020 ◽  
Author(s):  
Fabrice Caillol ◽  
Arthur Falque ◽  
Margherita Pizzicannella ◽  
Christian Pesenti ◽  
Jean Philippe Ratone ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Endoscopic Resection ◽  
Barrett’S Oesophagus ◽  
Low Grade ◽  
Barrett's Oesophagus ◽  
Low Grade Dysplasia
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