Tissue distribution of mutant mitochondrial DNA in mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)

1993 ◽  
Vol 16 (1) ◽  
pp. 27-30 ◽  
Author(s):  
Y. Shoji ◽  
W. Sato ◽  
K. Hayasaka ◽  
G. Takada
Keyword(s):  
Mitochondrial Dna ◽  
Lactic Acidosis ◽  
Tissue Distribution ◽  
Mitochondrial Myopathy

Mitochondrial DNA mutations in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)

1991 ◽  
Vol 174 (2) ◽  
pp. 861-868 ◽  
Author(s):  
Masashi Tanaka ◽  
Hidekazu Ino ◽  
Kinji Ohno ◽  
Toshihiro Ohbayashi ◽  
Shin-ichiro Ikebe ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Lactic Acidosis ◽  
Mitochondrial Myopathy ◽  
Mitochondrial Dna Mutations ◽  
Dna Mutations

Widespread tissue distribution of multiple mitochondrial DNA deletions in familial mitochondrial myopathy

1994 ◽  
Vol 17 (7) ◽  
pp. 741-746 ◽  
Author(s):  
Shingo Kawashima ◽  
Shigeo Ohta ◽  
Yasuo Kagawa ◽  
Mitsuo Yoshida ◽  
Masatoyo Nishizawa
Keyword(s):  
Mitochondrial Dna ◽  
Tissue Distribution ◽  
Mitochondrial Myopathy ◽  
Dna Deletions

Mitochondrial DNA deletion in a patient with mitochondrial myopathy, lactic acidosis, and stroke-like episodes (MELAS) and Fanconi's syndrome

1995 ◽  
Vol 13 (1) ◽  
pp. 69-72 ◽  
Author(s):  
Yolanda Campos ◽  
Teresa Garcia-Silva ◽  
Carlos R. Barrionuevo ◽  
Ana Cabello ◽  
Rafael Muley ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Lactic Acidosis ◽  
Mitochondrial Myopathy ◽  
Mitochondrial Dna Deletion ◽  
Dna Deletion ◽  
Fanconi’S Syndrome ◽  
Fanconi's Syndrome

Paradoxical effect of sodium valproate that aggravates epilepsy of MELAS in a patient with A3243G mutation of the mitochondrial DNA

Open Medicine ◽  
2007 ◽  
Vol 2 (1) ◽  
pp. 103-107 ◽  
Author(s):  
Yi-Min Chen ◽  
Chih-Ming Lin ◽  
Peterus Thajeb
Keyword(s):  
Mitochondrial Dna ◽  
Lactic Acidosis ◽  
Sodium Valproate ◽  
Mitochondrial Myopathy ◽  
Common Mutation ◽  
Nucleotide Position ◽  
Paradoxical Effect ◽  
A3243g Mutation

AbstractEpilepsy is an associated feature of patients with the syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). A substitution at nucleotide position 3243 A>G of the mitochondrial DNA is the most common mutation encountered both in Caucasians and in Chinese/Taiwanese. We herein report a 38-year-old man with A3243G mutation of the mitochondrial DNA whom developed MELAS. The manifestation of his focal motor epilepsy was aggravated by use of sodium valproate (VPA). The mechanism of this paradoxical effect is proposed.

The 3260 mutation in mitochondrial DNA can cause mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS)

1996 ◽  
Vol 19 (12) ◽  
pp. 1603-1604 ◽  
Author(s):  
Ichizo Nishino ◽  
Mikio Komatsu ◽  
Soichi Kodama ◽  
Satoshi Horai ◽  
Ikuya Nonaka ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Lactic Acidosis ◽  
Mitochondrial Myopathy

Mitochondrial DNA mutation and muscle pathology in mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes

1995 ◽  
Vol 18 (S14) ◽  
pp. S113-S118 ◽  
Author(s):  
Shuji Mita ◽  
Makoto Tokunaga ◽  
Toshihide Kumamoto ◽  
Makoto Uchino ◽  
Ikuya Nonaka ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Lactic Acidosis ◽  
Mitochondrial Myopathy ◽  
Muscle Pathology ◽  
Mitochondrial Dna Mutation ◽  
Dna Mutation
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