Localization of kappa opioid receptor binding sites in human forebrain using [3H]U69,593: Comparison with [3H]bremazocine

1987 ◽  
Vol 7 (3) ◽  
pp. 303-307 ◽  
Author(s):  
R�mi Quirion ◽  
Carmencita Pilapil ◽  
Jacques Magnan
Keyword(s):  
Opioid Receptor ◽  
Receptor Binding ◽  
Binding Sites ◽  
Kappa Opioid Receptor ◽  
Kappa Opioid ◽  
Opioid Receptor Binding

scholarly journals Kappa opioid receptor binding in major depression: A pilot study

Synapse ◽  
2018 ◽  
Vol 72 (9) ◽  
pp. e22042 ◽  
Author(s):  
Jeffrey M. Miller ◽  
Francesca Zanderigo ◽  
Priya D. Purushothaman ◽  
Christine DeLorenzo ◽  
Harry Rubin-Falcone ◽  
...  
Keyword(s):  
Pilot Study ◽  
Major Depression ◽  
Opioid Receptor ◽  
Receptor Binding ◽  
Kappa Opioid Receptor ◽  
Kappa Opioid ◽  
Opioid Receptor Binding

The mu1, mu2, delta, kappa opioid receptor binding profiles of methadone stereoisomers and morphine

Life Sciences ◽  
1994 ◽  
Vol 56 (2) ◽  
pp. 45-50 ◽  
Author(s):  
Kim Kristensen ◽  
Christian Broen Christensen ◽  
Lona L. Christrup
Keyword(s):  
Opioid Receptor ◽  
Receptor Binding ◽  
Kappa Opioid Receptor ◽  
Kappa Opioid ◽  
Opioid Receptor Binding

scholarly journals A DFT and Semiempirical Model-Based Study of Opioid Receptor Affinity and Selectivity in a Group of Molecules with a Morphine Structural Core

2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Tamara Bruna-Larenas ◽  
Juan S. Gómez-Jeria
Keyword(s):  
Binding Affinity ◽  
Opioid Receptor ◽  
Receptor Binding ◽  
Kappa Opioid Receptor ◽  
Kappa Opioid ◽  
Receptor Binding Affinity ◽  
Reactivity Indices ◽  
Model Based ◽  
Local Reactivity ◽  
Opioid Receptor Binding

We report the results of a search for model-based relationships between mu, delta, and kappa opioid receptor binding affinity and molecular structure for a group of molecules having in common a morphine structural core. The wave functions and local reactivity indices were obtained at the ZINDO/1 and B3LYP/6-31 levels of theory for comparison. New developments in the expression for the drug-receptor interaction energy expression allowed several local atomic reactivity indices to be included, such as local electronic chemical potential, local hardness, and local electrophilicity. These indices, together with a new proposal for the ordering of the independent variables, were incorporated in the statistical study. We found and discussed several statistically significant relationships for mu, delta, and kappa opioid receptor binding affinity at both levels of theory. Some of the new local reactivity indices incorporated in the theory appear in several equations for the first time in the history of model-based equations. Interaction pharmacophores were generated for mu, delta, and kappa receptors. We discuss possible differences regulating binding and selectivity in opioid receptor subtypes. This study, contrarily to the statistically backed ones, is able to provide a microscopic insight of the mechanisms involved in the binding process.

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