A developmental study of the synovial membrane of the rat temporomandibular joint: changes in the three-dimensional configuration during postnatal development

1995 ◽  
Vol 192 (4) ◽  
pp. 309-317 ◽  
Author(s):  
Masashi Tsuyama ◽  
Hiroshi Fukuda ◽  
Minoru Wakita
Keyword(s):  
Temporomandibular Joint ◽  
Postnatal Development ◽  
Synovial Membrane ◽  
Three Dimensional ◽  
Developmental Study ◽  
Three Dimensional Configuration

scholarly journals Improvement on Permeability of Cyclic Peptide/Peptidomimetic: Backbone N-Methylation as A Useful Tool

Marine Drugs ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. 311
Author(s):  
Yang Li ◽  
Wang Li ◽  
Zhengshuang Xu
Keyword(s):  
Cyclic Peptides ◽  
Cyclic Peptide ◽  
Three Dimensional ◽  
Conformational Space ◽  
Cell Permeability ◽  
Relative Importance ◽  
Intrinsic Properties ◽  
Surface Areas ◽  
Synthetic Methodologies ◽  
Three Dimensional Configuration

Peptides have a three-dimensional configuration that can adopt particular conformations for binding to proteins, which are well suited to interact with larger contact surface areas on target proteins. However, low cell permeability is a major challenge in the development of peptide-related drugs. In recent years, backbone N-methylation has been a useful tool for manipulating the permeability of cyclic peptides/peptidomimetics. Backbone N-methylation permits the adjustment of molecule’s conformational space. Several pathways are involved in the drug absorption pathway; the relative importance of each N-methylation to total permeation is likely to differ with intrinsic properties of cyclic peptide/peptidomimetic. Recent studies on the permeability of cyclic peptides/peptidomimetics using the backbone N-methylation strategy and synthetic methodologies will be presented in this review.

Pit pattern and three-dimensional configuration of isolated crypts from the patients with colorectal neoplasm

2002 ◽  
Vol 37 (10) ◽  
pp. 798-806 ◽  
Author(s):  
Satoru Tamura ◽  
Yasuo Furuya ◽  
Takehisa Tadokoro ◽  
Yoshifumi Higashidani ◽  
Yuichi Yokoyama ◽  
...  
Keyword(s):  
Colorectal Neoplasm ◽  
Three Dimensional ◽  
Pit Pattern ◽  
Three Dimensional Configuration

scholarly journals Quantitative measurement of syndesmophyte volume and height in ankylosing spondylitis using CT

2013 ◽  
Vol 73 (3) ◽  
pp. 544-550 ◽  
Author(s):  
Sovira Tan ◽  
Jianhua Yao ◽  
John A Flynn ◽  
Lawrence Yao ◽  
Michael M Ward
Keyword(s):  
Ankylosing Spondylitis ◽  
Dimensional Space ◽  
Three Dimensional ◽  
Reliability And Validity ◽  
Intervertebral Disk ◽  
Ct Scans ◽  
Developmental Study ◽  
Coefficients Of Variation ◽  
Spine Ct ◽  
Computer Based

ObjectiveSyndesmophyte growth in ankylosing spondylitis can be difficult to measure using radiographs because of poor visualisation and semiquantitative scoring methods. We developed and tested the reliability and validity of a new computer-based method that fully quantifies syndesmophyte volumes and heights on CT scans.MethodsIn this developmental study, we performed lumbar spine CT scans on 38 patients and used our algorithm to compute syndesmophyte volume and height in four intervertebral disk spaces. To assess reliability, we compared results between two scans performed on the same day in nine patients. To assess validity, we compared computed measures to visual ratings of syndesmophyte volume and height on both CT scans and radiographs by two physician readers.ResultsCoefficients of variation for syndesmophyte volume and height, based on repeat scans, were 2.05% and 2.40%, respectively. Based on Bland–Altman analysis, an increase in syndesmophyte volume of more than 4% or in height of more than 0.20 mm represented a change greater than measurement error. Computed volumes and heights were strongly associated with physician ratings of syndesmophyte volume and height on visual examination of both the CT scans (p<0.0001) and plain radiographs (p<0.002). Syndesmophyte volumes correlated with the Schober test (r=−0.48) and lateral thoracolumbar flexion (r=−0.60).ConclusionsThis new CT-based method that fully quantifies syndesmophytes in three-dimensional space had excellent reliability and face and construct validity. Given its high precision, this method shows promise for longitudinal clinical studies of syndesmophyte development and growth.

Three-Dimensional Configuration of Subretinal Fluid in Central Serous Chorioretinopathy

2013 ◽  
Vol 54 (9) ◽  
pp. 5944 ◽  
Author(s):  
Soh-Eun Ahn ◽  
Jaeryung Oh ◽  
Jong-Hyun Oh ◽  
In Kyung Oh ◽  
Seong-Woo Kim ◽  
...  
Keyword(s):  
Central Serous Chorioretinopathy ◽  
Three Dimensional ◽  
Subretinal Fluid ◽  
Three Dimensional Configuration
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