The effect of vitamin A (retinoids) on pattern formation implies a uniformity of developmental mechanisms throughout the animal kingdom

1993 ◽  
Vol 41 (4) ◽  
pp. 425-445 ◽  
Author(s):  
Malcolm Maden
Keyword(s):  
Pattern Formation ◽  
Vitamin A ◽  
Animal Kingdom ◽  
Developmental Mechanisms

The effect of vitamin A on the regenerating axolotl limb

Development ◽  
1983 ◽  
Vol 77 (1) ◽  
pp. 273-295
Author(s):  
M. Maden
Keyword(s):  
Retinoic Acid ◽  
Cell Division ◽  
Pattern Formation ◽  
Vitamin A ◽  
Cellular Effects ◽  
Tissue Changes ◽  
Time Of Administration

These experiments describe further investigations into the effects of vitamin A on regenerating limbs. The effects of different retinoids, the time of administration, concentration of vitamin A and histological, autoradiographic and histochemical studies are reported. The most obvious result of vitamin A treatment is to cause proximal elements to regeneratefrom distal amputation levels, that is to cause serial reduplication of pattern inthe proximodistal axis. Retinoic acid was the most potent of the analogues tested and longer times of administration or higher concentrations cause a greater amount of serial reduplication. Various tissue changes have been found which include the inhibition of cell division, loss of cartilage metachromasia, changes in the mucous-secreting properties of the epidermis and an increased packing in the blastemal cells. The significance of these cellular effects in relation to the pattern-formation changes is discussed.

Morphogenesis of the amphibian limb blastema: The relationship between pattern and form

Development ◽  
1984 ◽  
Vol 79 (1) ◽  
pp. 165-181
Author(s):  
Nigel Holder ◽  
Susan Reynolds
Keyword(s):  
Pattern Formation ◽  
Vitamin A ◽  
Short Range ◽  
Range Cell ◽  
Limb Pattern ◽  
The Relationship ◽  
Pattern Regulation ◽  
Thigh Region ◽  
Short Arc ◽  
Number Of Cells

A relationship between pattern formation and field shape is established following the formation of rounded blastemas on lower arm limb stumps after treatment with vitamin A. Pattern formation is not affected by alteration in blastemal shape caused by removal of the dermis from the thigh region of the leg. We conclude, therefore, that blastemal shape does not play a causal role in establishing limb pattern. Data relating the number of cells present between the cardinal axial poles of blastemas and the size of blastemas is discussed in terms of short arc intercalation and short range cell—cell interactions during pattern regulation.

Pattern formation and developmental mechanisms

1993 ◽  
Vol 3 (4) ◽  
pp. 553-555 ◽  
Author(s):  
Peter Gruss ◽  
William McGinnis
Keyword(s):  
Pattern Formation ◽  
Developmental Mechanisms

Pattern formation and developmental mechanisms

2005 ◽  
Vol 15 (4) ◽  
pp. 355-357 ◽  
Author(s):  
William McGinnis ◽  
Cheryll Tickle
Keyword(s):  
Pattern Formation ◽  
Developmental Mechanisms

Pattern formation and developmental mechanisms

2004 ◽  
Vol 14 (4) ◽  
pp. 325-327
Author(s):  
Derek L Stemple ◽  
Jean-Paul Vincent
Keyword(s):  
Pattern Formation ◽  
Developmental Mechanisms

Genetic analysis of developmental mechanisms in hydra. VIII. Head-activation and head-inhibition potentials of a slow-budding strain (L4)

Development ◽  
1983 ◽  
Vol 78 (1) ◽  
pp. 141-168 ◽  
Author(s):  
Jun Takano ◽  
Tsutomu Sugiyama
Keyword(s):  
Pattern Formation ◽  
Genetic Analysis ◽  
Structure Formation ◽  
Tissue Transplantation ◽  
Normal Strain ◽  
Polyp Size ◽  
Developmental Mechanisms ◽  
Head Formation ◽  
Lower Head ◽  
Activation Potential

Morphogenetic potentials involved in head formation were examined in a hydra strain (L4) which has a very low budding rate and a large polyp size, and the results were compared to those of the normal strain (105). Hydra tissue has two types of antagonistic morphogenetic potentials which are thought to play important roles in head structure formation: the head-activation potential and the head-inhibition potential. Lateral tissue transplantation (Webster & Wolpert, 1966) was used to compare the levels of the two potentials in L4 and the normal strain. It was found that the intact polyp of L4 has a nearly normal or slightly lower head-activation potential but a significantly higher head-inhibition potential than the normal strain. During the course of regeneration after head amputation, the levels of the two potentials in L4 changed in significantly different patterns from those in the normal strain. These abnormalities of the two potentials may be responsible for the developmental and morphological abnormalities in L4. The significance of these observations is discussed in light of the current hydra pattern formation models (Wolpert, Hornchurch & Clarke, 1974; Meinhardt & Gierer, 1974).

Sign in / Sign up

Export Citation Format

Share Document