Hypothalamic neuronal hamartoma associated with pituitary growth hormone cell adenoma and acromegaly

1980 ◽  
Vol 52 (3) ◽  
pp. 231-234 ◽  
Author(s):  
Sylvia L. Asa ◽  
Juan M. Bilbao ◽  
Kalman Kovacs ◽  
John A. Linfoot
Keyword(s):  
Growth Hormone ◽  
Cell Adenoma ◽  
Pituitary Growth Hormone ◽  
Growth Hormone Cell

scholarly journals Different Degrees of Somatotroph Ablation Compromise Pituitary Growth Hormone Cell Network Structure and Other Pituitary Endocrine Cell Types

Endocrinology ◽  
2010 ◽  
Vol 151 (1) ◽  
pp. 234-243 ◽  
Author(s):  
Eleanor Waite ◽  
Chrystel Lafont ◽  
Danielle Carmignac ◽  
Norbert Chauvet ◽  
Nathalie Coutry ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Network Structure ◽  
Endocrine Cell ◽  
Cell Types ◽  
Cell Network ◽  
Pituitary Growth Hormone ◽  
Growth Hormone Cell

Downregulation of E-Cadherin and Its Undercoat Proteins in Pituitary Growth Hormone Cell Adenomas with Prominent Fibrous Bodies

2002 ◽  
Vol 13 (4) ◽  
pp. 341-352 ◽  
Author(s):  
Bing Xu ◽  
Toshiaki Sano ◽  
Katsuhiko Yoshimoto ◽  
Shozo Yamada
Keyword(s):  
Growth Hormone ◽  
Pituitary Growth Hormone ◽  
Growth Hormone Cell ◽  
E Cadherin

Mammosomatotroph Cell Adenoma of the Human Pituitary

1980 ◽  
Vol 38 ◽  
pp. 726-727 ◽  
Author(s):  
E. Horvath ◽  
K. Kovacs ◽  
D.W. Killinger ◽  
H.S. Smythe ◽  
M.E. Platts ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Ultrastructural Level ◽  
Tumor Type ◽  
Prolactin Cells ◽  
Human Pituitary ◽  
Cell Adenoma ◽  
Morphologic Study ◽  
Common Precursor ◽  
Growth Hormone Cell ◽  
The Common

In the morphologic study of surgically-removed pituitary adenomas, histology, electron microscopy as well as immunocytochemistry at the light microscopic and ultrastructural level were used. In material of 370 adenomas, 226 tumors (61.7%) were found to derive from the “acidophil” cell line. Thirty-one of these were densely granulated growth hormone cell adenomas; 38 were sparsely granulated growth hormone cell adenomas; 1 was composed of densely granulated prolactin cells and 114 of sparsely granulated prolactin cells. The latter represent the most common tumor type in the human pituitary. Twentyone adenomas were mixed, consisting of growth hormone cells and prolactin cells; 17 tumors were classified as acidophil stem cell adenomas. The latter are immature, aggressive neoplasms assumed to originate in the common precursor of growth hormone cells and prolactin cells.

scholarly journals The FGFR4-G388R Polymorphism Promotes Mitochondrial STAT3 Serine Phosphorylation to Facilitate Pituitary Growth Hormone Cell Tumorigenesis

PLoS Genetics ◽  
2011 ◽  
Vol 7 (12) ◽  
pp. e1002400 ◽  
Author(s):  
Toru Tateno ◽  
Sylvia L. Asa ◽  
Lei Zheng ◽  
Thomas Mayr ◽  
Axel Ullrich ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Serine Phosphorylation ◽  
Pituitary Growth Hormone ◽  
Growth Hormone Cell

Formation of Centrioles in Some Endocrine Adenomas

1975 ◽  
Vol 33 ◽  
pp. 376-377
Author(s):  
E. Horvath ◽  
K. Kovacs
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenomas ◽  
Osmium Tetroxide ◽  
Mitotic Division ◽  
Mixed Cell ◽  
Pituitary Growth Hormone ◽  
Parathyroid Adenomas ◽  
Growth Hormone Cell ◽  
Formation And Evolution ◽  
Insight Into

Centrioles, known to play a fundamental role in mitotic division, are regarded as representing self-replicating organelles. They occur with varying frequency in different normal cells and exhibit uniform appearances showing no signs indicative of duplication such as budding or division. In order to obtain a deeper insight into centriole formation and evolution, cases of parathyroid and pituitary adenomas with a high centriole population were investigated by electron microscopy.The material used for the present study consisted of 4 chief cell adenomas of the parathyroid gland, 7 sparsely granulated pituitary growth hormone cell adenomas and 1 mixed cell pituitary adenoma composed of sparsely granulated growth hormone cells and prolactin cells. These adenomas were selected from a large number of cases (26 parathyroid adenomas and 49 pituitary adenomas). All specimens were obtained by surgery from various patients with hyperparathyroidism or acromegaly. Small pieces of tissue were fixed immediately after removal in 2.5 per cent glutaraldehyde in Sorensen's buffer, postfixed in 1 per cent osmium tetroxide in Millonig's buffer, dehydrated in graded ethanol and embedded in Epon 812.

TRIAL OF PITUITARY GROWTH HORMONE: IN A CASE OF HYPERINSULINISM DUE TO ISLET-CELL ADENOMA

The Lancet ◽  
1952 ◽  
Vol 259 (6697) ◽  
pp. 19-21 ◽  
Author(s):  
K.O. Black ◽  
I. Macdougall ◽  
E. Reid ◽  
F.G. Young
Keyword(s):  
Growth Hormone ◽  
Islet Cell ◽  
Cell Adenoma ◽  
Pituitary Growth Hormone

scholarly journals Experimental modification of rat pituitary growth hormone cell function during and after spaceflight

1996 ◽  
Vol 80 (3) ◽  
pp. 955-970 ◽  
Author(s):  
W. C. Hymer ◽  
R. E. Grindeland ◽  
T. Salada ◽  
P. Nye ◽  
E. J. Grossman ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Cell Function ◽  
Cell Types ◽  
Secretory Cells ◽  
Mixed Cell ◽  
Pituitary Growth Hormone ◽  
Gh Cells ◽  
Growth Hormone Cell ◽  
And Function

Space-flown rats show a number of flight-induced changes in the structure and function of pituitary growth hormone (GH) cells after in vitro postflight testing (W. C. Hymen, R. E. Grindeland, I. Krasnov, I, Victorov, K. Motter, P. Mukherjee, K. Shellenberger, and M. Vasques. J. Appl. Physiol. 73, Suppl.: 151S-157S, 1992). To evaluate the possible effects of microgravity on growth hormone (GH) cells themselves, freshly dispersed rat anterior pituitary gland cells were seeded into vials containing serum +/- microM hydrocortisone (HC) before flight. Five different cell preparations were used: the entire mixed-cell population of various hormone-producing cell types, cells of density < 1.071 g/cm3 (band 1), cells of density > 1.071 g/cm3 (band 2), and cells prepared from either the dorsal or ventral part of the gland. Relative to ground control samples, bioactive GH released from dense cells during flight was reduced in HC-free medium but was increased in HC-containing medium. Band 1 and mixed cells usually showed opposite HC-dependent responses. Release of bioactive GH from ventral flight cells was lower; postflight responses to GH-releasing hormone challenge were reduced, and the cytoplasmic area occupied by GH in the dense cells was greater. Collectively, the data show that the chemistry and cellular makeup of the culture system modifies the response of GH cells to microgravity. As such, these cells offer a system to identify gravisensing mechanisms in secretory cells in future microgravity research.

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