Soluble brain proteins in dialysis encephalopathy

1980 ◽  
Vol 50 (3) ◽  
pp. 241-244 ◽  
Author(s):  
Bengt Hindfelt ◽  
Jan-Edvin Olsson
Keyword(s):  
Brain Proteins ◽  
Dialysis Encephalopathy ◽  
Soluble Brain Proteins

Isoelectric focusing of soluble brain proteins and changes associated with development

1970 ◽  
Vol 24 (3) ◽  
pp. 537-540 ◽  
Author(s):  
A.L. Griffith ◽  
Arthur LaVelle ◽  
N. Catsimpoolas
Keyword(s):  
Isoelectric Focusing ◽  
Brain Proteins ◽  
Soluble Brain Proteins

A simplified method to prepare soluble brain proteins for electrophoresis

1966 ◽  
Vol 13 (1) ◽  
pp. 119-121 ◽  
Author(s):  
A. Allegranza ◽  
P. Canevini ◽  
P. Mocarelli
Keyword(s):  
Brain Proteins ◽  
Simplified Method ◽  
Soluble Brain Proteins

Two-dimensional map of human brain proteins

1999 ◽  
Vol 20 (4-5) ◽  
pp. 907-916 ◽  
Author(s):  
Hanno Langen ◽  
Peter Berndt ◽  
Daniel Röder ◽  
Nigel Cairns ◽  
Gert Lubec ◽  
...  
Keyword(s):  
Human Brain ◽  
Two Dimensional ◽  
Brain Proteins

scholarly journals Proteome analysis of brain proteins in Alzheimer's disease: Subproteomics following sequentially extracted protein preparation

2004 ◽  
Vol 6 (3) ◽  
pp. 257-268 ◽  
Author(s):  
Aiko Shiozaki ◽  
Teruyuki Tsuji ◽  
Ryuichi Kohno ◽  
Jun Kawamata ◽  
Kengo Uemura ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Proteome Analysis ◽  
Protein Preparation ◽  
Brain Proteins

A Proteome-Wide Association Study Identified Candidate Human Brain Proteins Associated with Coffee Consumption

2021 ◽  
Author(s):  
Chun'e Li ◽  
Xiao Liang ◽  
Yumeng Jia ◽  
Yan Wen ◽  
Huijie Zhang ◽  
...  
Keyword(s):  
Human Brain ◽  
Association Study ◽  
Plasma Proteins ◽  
Genome Wide Association Study ◽  
Genetic Correlations ◽  
Coffee Consumption ◽  
Genetic Associations ◽  
Brain Proteins ◽  
Genome Wide ◽  
Brain Proteome

Abstract Background Increasing evidence suggests the association between caffeine and the brain and nervous system. However, there is limited research on the genetic associations between coffee consumption subtypes and brain proteome, plasma proteomes, and peripheral metabolites. Methods First, proteome-wide association study (PWAS) of coffee consumption subtypes was performed by integrating two independent genome-wide association study (GWAS) datasets (91,462–502,650 subjects) with two reference human brain proteomes (ROS/MAP and Banner), by using the FUSION pipeline. Second, transcriptome-wide association study (TWAS) analysis of coffee consumption subtypes was conducted by integrating the two gene expression weight references (RNAseq and splicing) of brain RNA-seq and the two GWAS datasets (91,462–502,650 subjects) of coffee consumption subtypes. Finally, we used the LD Score Regression (LDSC) analysis to evaluate the genetic correlations of coffee consumption subtypes with plasma proteomes and peripheral metabolites. Results For the traits related to coffee consumption, we identified 3 common PWAS proteins, such as MADD (P PWAS−Banner−dis=0.0114, P PWAS−ROS/MAP−rep =0.0489). In addition, 11 common TWAS genes were found in two cohorts, such as ARPC2 (P TWAS−splicing−dis =2063×10− 12, P TWAS−splicing−dis =1.25×10− 10, P TWAS−splicing−dis =1.24e-08, P TWAS−splicing−rep =3.25×10− 9 and P TWAS−splicing−rep =3.42×10− 13). Importantly, we have identified 8 common genes between PWAS and TWAS, such as ALDH2 (P PWAS−banner−rep =1.22×10− 22, PTWAS− splicing−dis = 4.54×10− 92). For the LDSC analysis of human plasma proteome, we identified 11 plasma proteins, such as CHL1 (P dis = 0.0151, P rep =0.0438). For the LDSC analysis of blood metabolites, 5 metabolites have been found, such as myo-inositol (P dis = 0.0073, P dis = 0.0152, P dis =0.0414, P rep =0.0216). Conclusions We identified several brain proteins and genes associated with coffee consumption subtypes. In addition, we also detected several candidate plasma proteins and metabolites related to these subtypes.

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