Spectrum of morphological appearance of amyloid deposits in Alzheimer's disease

1989 ◽  
Vol 78 (4) ◽  
pp. 337-347 ◽  
Author(s):  
H. M. Wisniewski ◽  
C. Bancher ◽  
M. Barcikowska ◽  
G. Y. Wen ◽  
J. Currie
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Morphological Appearance ◽  
Amyloid Deposits

TSPO and amyloid deposits in sub-regions of the hippocampus in the 3xTgAD mouse model of Alzheimer’s disease

2019 ◽  
Vol 121 ◽  
pp. 95-105 ◽  
Author(s):  
Benjamin B. Tournier ◽  
Stergios Tsartsalis ◽  
Daphney Rigaud ◽  
Christine Fossey ◽  
Thomas Cailly ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
Amyloid Deposits

scholarly journals Morphology and Toxicity of Aβ-(1-42) Dimer Derived from Neuritic and Vascular Amyloid Deposits of Alzheimer's Disease

1996 ◽  
Vol 271 (34) ◽  
pp. 20631-20635 ◽  
Author(s):  
Alex E. Roher ◽  
Michael O. Chaney ◽  
Yu-Min Kuo ◽  
Scott D. Webster ◽  
W. Blaine Stine ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Deposits

scholarly journals Transcranial in vivo detection of amyloid-beta at single plaque resolution with large-field multifocal illumination fluorescence microscopy

2020 ◽  
Author(s):  
Ruiqing Ni ◽  
Zhenyue Chen ◽  
Gloria Shi ◽  
Alessia Villois ◽  
Quanyu Zhou ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fluorescence Microscopy ◽  
Amyloid Beta ◽  
Large Field ◽  
Microscopy Technique ◽  
In Vivo Detection ◽  
Amyloid Deposits ◽  
Microscopy Techniques

AbstractThe abnormal deposition of beta-amyloid proteins in the brain is one of the major histopathological hallmarks of Alzheimer’s disease. Currently available intravital microscopy techniques for high-resolution plaque visualization commonly involve highly invasive procedures and are limited to a small field-of-view within the rodent brain. Here, we report the transcranial detection of amyloid-beta deposits at the whole brain scale with 20 μm resolution in APP/PS1 and arcAβ mouse models of Alzheimer’s disease amyloidosis using a large-field multifocal (LMI) fluorescence microscopy technique. Highly sensitive and specific detection of amyloid-beta deposits at a single plaque level in APP/PS1 and arcAβ mice was facilitated using luminescent conjugated oligothiophene HS-169. Immunohistochemical staining with HS-169, anti-Aβ antibody 6E10, and conformation antibodies OC (fibrillar) of brain tissue sections further showed that HS-169 resolved compact parenchymal and vessel-associated amyloid deposits. The novel imaging platform offers new prospects for in vivo studies into Alzheimer’s disease mechanisms in animal models as well as longitudinal monitoring of therapeutic responses at a single plaque level.

scholarly journals Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease

2002 ◽  
Vol 99 (22) ◽  
pp. 13990-13995 ◽  
Author(s):  
B. Urbanc ◽  
L. Cruz ◽  
R. Le ◽  
J. Sanders ◽  
K. H. Ashe ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mice ◽  
Amyloid Deposits ◽  
Neurotoxic Effects
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