Cerebellar injury due to phenytoin. Identification and evolution of Purkinje cell axonal swellings in deep cerebellar nuclei of mice

1989 ◽  
Vol 77 (3) ◽  
pp. 289-298 ◽  
Author(s):  
R. Kiefer ◽  
R. Knoth ◽  
J. Anagnostopoulos ◽  
B. Volk
Keyword(s):  
Purkinje Cell ◽  
Cerebellar Nuclei ◽  
Deep Cerebellar Nuclei ◽  
Cerebellar Injury ◽  
Axonal Swellings

Dynamic Synchronization of Purkinje Cell Simple Spikes

2006 ◽  
Vol 96 (6) ◽  
pp. 3485-3491 ◽  
Author(s):  
Soon-Lim Shin ◽  
Erik De Schutter
Keyword(s):  
Purkinje Cell ◽  
Firing Rate ◽  
Purkinje Cells ◽  
Cerebellar Cortex ◽  
Cerebellar Nuclei ◽  
Temporal Coding ◽  
Sharp Peak ◽  
Deep Cerebellar Nuclei

Purkinje cells (PCs) integrate all computations performed in the cerebellar cortex to inhibit neurons in the deep cerebellar nuclei (DCN). Simple spikes recorded in vivo from pairs of PCs separated by <100 μm are known to be synchronized with a sharp peak riding on a broad peak, but the significance of this finding is unclear. We show that the sharp peak consists exclusively of simple spikes associated with pauses in firing. The broader, less precise peak was caused by firing-rate co-modulation of faster firing spikes. About 13% of all pauses were synchronized, and these pauses had a median duration of 20 ms. As in vitro studies have reported that synchronous pauses can reliably trigger spikes in DCN neurons, we suggest that the subgroup of spikes causing the sharp peak is important for precise temporal coding in the cerebellum.

scholarly journals Purkinje cell BKchannel ablation induces abnormal rhythm in deep cerebellar nuclei and prevents LTD

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Guy Cheron ◽  
Javier Márquez-Ruiz ◽  
Julian Cheron ◽  
Cynthia Prigogine ◽  
Claudia Ammann ◽  
...  
Keyword(s):  
Purkinje Cell ◽  
Cerebellar Nuclei ◽  
Deep Cerebellar Nuclei

scholarly journals Calcium imaging reveals coordinated simple spike pauses in populations of Cerebellar Purkinje cells

2016 ◽  
Author(s):  
Jorge E. Ramirez ◽  
Brandon M. Stell
Keyword(s):  
Purkinje Cell ◽  
Purkinje Cells ◽  
Calcium Imaging ◽  
Spatial Organization ◽  
Cell Activity ◽  
Cerebellar Nuclei ◽  
Deep Cerebellar Nuclei ◽  
Firing Rates ◽  
Simple Spike ◽  
Cerebellar Purkinje Cells

The brain’s control of movement is thought to involve coordinated activity between cerebellar Purkinje cells. The results reported here demonstrate that somatic Ca2+ imaging is a faithful reporter of Na+-dependent “simple spike” pauses and enables us to optically record changes in firing rates in populations of Purkinje cells. This simultaneous calcium imaging of populations of Purkinje cells reveals a striking spatial organization of pauses in Purkinje cell activity between neighboring cells. The source of this organization is shown to be the presynaptic GABAergic network and blocking GABAARs abolishes the synchrony. These data suggest that presynaptic interneurons synchronize (in)activity between neighboring Purkinje cells and thereby maximize their effect on downstream targets in the deep cerebellar nuclei.

No Clock Signal in the Discharge of Neurons in the Deep Cerebellar Nuclei

1997 ◽  
Vol 77 (4) ◽  
pp. 2232-2234 ◽  
Author(s):  
J. G. Keating ◽  
W. T. Thach
Keyword(s):  
Purkinje Cell ◽  
Fourier Transforms ◽  
Interval Data ◽  
Cerebellar Nuclei ◽  
Clock Signal ◽  
Deep Cerebellar Nuclei ◽  
Isolated Cells ◽  
Complex Spike ◽  
Cell Discharge ◽  
Behaving Monkeys

Keating, J. G. and W. T. Thach. No clock signal in the discharge of neurons in the deep cerebellar nuclei. J. Neurophysiol. 77: 2232–2234, 1997. We examined the spike activity of deep cerebellar nuclear cells recorded from awake, behaving monkeys to determine if there was a tendency for periodic discharge at or near 10 Hz. Data were obtained from four Rhesus monkeys trained to perform either targeted flexions and extensions of the wrist in relation to a visual cue (2 monkeys) or instrumented digit movements and natural reaches (2 monkeys). We determined the interspike intervals of 274 isolated cells. We looked for periodicity by autocorrelating the interval data and Fourier transforming the resulting autocorrelation function. The autocorrelograms and the Fourier transforms failed to reveal periodicity at or near 10 Hz for any cell. This lack of oscillatory discharge in deep nuclear cells of the cerebellum is consistent with our previously reported results that the complex spike of the Purkinje cell is aperiodic. Our failure to observe a clocklike timing signal in awake, behaving animals in either the Purkinje cell complex spike or the deep nuclear cell discharge argues against a popular idea that the inferior olive may act through the cerebellum as a motor clock.

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