Oligodendroglial pathology in canine distemper virus infection in vitro

1987 ◽  
Vol 74 (4) ◽  
pp. 366-373 ◽  
Author(s):  
A. Zurbriggen ◽  
M. Vandevelde ◽  
M. Dumas ◽  
C. Griot ◽  
E. Bollo
Keyword(s):  
Virus Infection ◽  
Canine Distemper Virus ◽  
Canine Distemper

scholarly journals Antiviral efficacy of favipiravir against canine distemper virus infection in vitro

2019 ◽  
Vol 15 (1) ◽  
Author(s):  
Xianghong Xue ◽  
Yelei Zhu ◽  
Lina Yan ◽  
Gary Wong ◽  
Peilu Sun ◽  
...  
Keyword(s):  
Virus Infection ◽  
Canine Distemper Virus ◽  
Canine Distemper ◽  
Antiviral Efficacy

scholarly journals In vitro Canine Distemper Virus Infection of Canine Lymphoid Cells: A Prelude to Oncolytic Therapy for Lymphoma

2005 ◽  
Vol 11 (4) ◽  
pp. 1579-1587 ◽  
Author(s):  
Steven E. Suter ◽  
May B. Chein ◽  
Veronika von Messling ◽  
Becky Yip ◽  
Roberto Cattaneo ◽  
...  
Keyword(s):  
Virus Infection ◽  
Canine Distemper Virus ◽  
Lymphoid Cells ◽  
Canine Distemper ◽  
Oncolytic Therapy

scholarly journals Intratumoral Canine Distemper Virus Infection Inhibits Tumor Growth by Modulation of the Tumor Microenvironment in a Murine Xenograft Model of Canine Histiocytic Sarcoma

2021 ◽  
Vol 22 (7) ◽  
pp. 3578
Author(s):  
Federico Armando ◽  
Adnan Fayyad ◽  
Stefanie Arms ◽  
Yvonne Barthel ◽  
Dirk Schaudien ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Virus Infection ◽  
Tumor Growth ◽  
Canine Distemper Virus ◽  
Xenograft Model ◽  
Histiocytic Sarcoma ◽  
Oncolytic Viruses ◽  
Canine Distemper ◽  
Murine Xenograft Model ◽  
The Impact

Histiocytic sarcomas refer to highly aggressive tumors with a poor prognosis that respond poorly to conventional treatment approaches. Oncolytic viruses, which have gained significant traction as a cancer therapy in recent decades, represent a promising option for treating histiocytic sarcomas through their replication and/or by modulating the tumor microenvironment. The live attenuated canine distemper virus (CDV) vaccine strain Onderstepoort represents an attractive candidate for oncolytic viral therapy. In the present study, oncolytic virotherapy with CDV was used to investigate the impact of this virus infection on tumor cell growth through direct oncolytic effects or by virus-mediated modulation of the tumor microenvironment with special emphasis on angiogenesis, expression of selected MMPs and TIMP-1 and tumor-associated macrophages in a murine xenograft model of canine histiocytic sarcoma. Treatment of mice with xenotransplanted canine histiocytic sarcomas using CDV induced overt retardation in tumor progression accompanied by necrosis of neoplastic cells, increased numbers of intratumoral macrophages, reduced angiogenesis and modulation of the expression of MMPs and TIMP-1. The present data suggest that CDV inhibits tumor growth in a multifactorial way, including direct cell lysis and reduction of angiogenesis and modulation of MMPs and their inhibitor TIMP-1, providing further support for the concept of its role in oncolytic therapies.

scholarly journals Canine distemper virus infection in a lesser grison (Galictis cuja): first report and virus phylogeny

2013 ◽  
Vol 33 (2) ◽  
pp. 247-250 ◽  
Author(s):  
Jane Megid ◽  
Carlos R. Teixeira ◽  
Adriana Cortez ◽  
Marcos B. Heinemann ◽  
João M.A.P. Antunes ◽  
...  
Keyword(s):  
Virus Infection ◽  
Canine Distemper Virus ◽  
Wildlife Conservation ◽  
Domestic Animals ◽  
Canine Distemper ◽  
Habitat Alterations ◽  
Source Of Infection ◽  
First Case ◽  
In Captivity ◽  
Free Ranging

Infectious diseases in wild animals have been increasing as a result of their habitat alterations and closer contact with domestic animals. Canine distemper virus (CDV) has been reported in several species of wild carnivores, presenting a threat to wildlife conservation. We described the first case of canine distemper virus infection in lesser grison (Galictis cuja). A free-ranging individual, with no visible clinical sigs, presented sudden death after one day in captivity. Molecular diagnosis for CDV infection was performed using whole blood collected by postmortem intracardiac puncture, which resulted positive. The virus phylogeny indicated that domestic dogs were the probable source of infection.

Virulence of tissue culture-propagated canine distemper virus

1980 ◽  
Vol 29 (3) ◽  
pp. 940-944 ◽  
Author(s):  
A E Metzler ◽  
R J Higgins ◽  
S Krakowka ◽  
A Koestner
Keyword(s):  
Tissue Culture ◽  
Neurological Disease ◽  
Canine Distemper Virus ◽  
In Vitro Growth ◽  
Canine Distemper ◽  
Passage Level ◽  
Pulmonary Macrophage

Virulence of canine distemper virus (CDV) adapted to in vitro growth in Vero or bovine cells was determined by inoculation into CDV-susceptible neonatal gnotobiotic dogs. When compared with dogs given virulent R252-CDV, Vero R252-CDV was attenuated at passage level 14. In contrast, dogs inoculated with bovine R252-CDV at the same passage level experienced rapid fatal neurological disease. Virulence was not linked to ability to infect or replicate in canine pulmonary macrophage cultures. Retention of virulence by bovine R252-CDV is unique and worthy of further study.

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