Determination of tumour vascularity using selective hepatic angiography as compared with intrahepatic-arterial technetium-99m macroaggregated albumin scan in hepatocellular carcinoma

1994 ◽  
Vol 33 (S1) ◽  
pp. S33-S36 ◽  
Author(s):  
Thomas W. T. Leung ◽  
Wan-yee Lau ◽  
Stephen K. W. Ho ◽  
Michael Chan ◽  
Nancy W. Y. Leung ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Technetium 99M ◽  
Macroaggregated Albumin ◽  
Tumour Vascularity ◽  
Hepatic Angiography

Pulmonary uptake of technetium 99m macroaggregated albumin: a predictor of gastrointestinal toxicity during hepatic artery perfusion.

1984 ◽  
Vol 2 (11) ◽  
pp. 1266-1269 ◽  
Author(s):  
W D Kaplan ◽  
S E Come ◽  
R W Takvorian ◽  
S M Laffin ◽  
R S Gelman ◽  
...  
Keyword(s):  
Hepatic Artery ◽  
Systemic Toxicity ◽  
Hepatic Artery Infusion ◽  
Pump System ◽  
Technetium 99M ◽  
Macroaggregated Albumin ◽  
Pulmonary Uptake ◽  
Slow Infusion ◽  
Gi Toxicity ◽  
Hepatic Angiography

Hepatic artery infusion of 5-fluoro-2-deoxyuridine (5-FUdR) provides high hepatic drug levels but little systemic toxicity, since, by this route of administration, the drug is detoxified by the hepatocytes. Slow infusion of technetium 99m- (99mTc) labeled macroaggregated albumin (MAA) through the hepatic artery is an aid in catheter placement, in predicting response of liver metastases to therapy, and in identifying extra-hepatic flow in the gastroduodenal or splenic arteries as an indicator of systemic toxicity. Marked pulmonary uptake of this tracer after slow radionuclide hepatic angiography was noted in four patients who showed major gastrointestinal (GI) toxicity. A retrospective examination of pulmonary accumulation of 99mTcMAA as a predictor of GI toxicity is the subject of this paper. Two groups of patients were evaluated. The first group consisted of 14 consecutive patients in whom continuous infusion of drug was administered by an external pump by way of a percutaneous catheter. Patients received baseline and follow-up (seven to 27 days) slow-infusion tracer studies (2 to 4 mCi 99mTcMAA at 10 to 21 mL/h). The second group included 14 consecutive patients who were receiving intraarterial chemotherapy by a totally implantable pump system. All received baseline slow-infusion studies (2 to 4 mCi 99mTcMAA at approximately 0.5 to 1.0 mL/min). The percentage of the injected dose in the lung was determined. Patients with greater than 20% of tracer in the lung after radionuclide hepatic angiography had significantly greater severe GI toxicity than patients with baseline values of less than 20%. Our findings support the existence of hepatic arteriovenous (A-V) communications in some patients and suggest that they are present pretherapy. Presence of these A-V communications, which can result in a vascular bypass of normal hepatic parenchyma and the subsequent decrease in hepatic detoxification of chemotherapeutic agents, is the likely cause of GI toxicity. Pulmonary uptake of tracer injected in the hepatic artery may be useful in quantifying the degree of shunting and facilitate the monitoring of potential systemic toxicity.

Chromatographic determination of some biomarkers of liver cirrhosis and hepatocellular carcinoma in Egyptian patients

2016 ◽  
Vol 31 (6) ◽  
pp. e3893 ◽  
Author(s):  
Diaa Osman ◽  
Omnia Ali ◽  
Manar Obada ◽  
Hatem El-Mezayen ◽  
Hala El-Said
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Chromatographic Determination ◽  
Egyptian Patients

scholarly journals Transportal Technetium-99m Labeled Macroaggregated Albumin Scintigraphy to Quantify Occult Intrahepatic Microvascular Portosystemic Shunting

2021 ◽  
Vol 16 (4) ◽  
pp. 975-978
Author(s):  
Cynthia De la Garza-Ramos ◽  
Mohamed S. Muneer ◽  
Jason T. Lewis ◽  
Denise M. Harnois ◽  
C. Burcin Taner ◽  
...  
Keyword(s):  
Technetium 99M ◽  
Macroaggregated Albumin ◽  
Portosystemic Shunting

Screening for Hepatopulmonary Syndrome in Cirrhotic Patients Using Technetium 99m-macroaggregated Albumin Perfusion Lung Scan (Tc-MAA)

2018 ◽  
Vol 52 (9) ◽  
pp. 828-834 ◽  
Author(s):  
Maria Fragaki ◽  
Dimitra Sifaki-Pistolla ◽  
Dimitrios N. Samonakis ◽  
Mairi Koulentaki ◽  
Sofia Koukouraki ◽  
...  
Keyword(s):  
Hepatopulmonary Syndrome ◽  
Technetium 99M ◽  
Macroaggregated Albumin ◽  
Lung Scan ◽  
Cirrhotic Patients
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