Distribution of cisplatin in perilymph and cerebrospinal fluid after intravenous administration in the guinea pig

1995 ◽  
Vol 36 (1) ◽  
pp. 83-86 ◽  
Author(s):  
Goran Laurell ◽  
Anita Andersson ◽  
Berit Engstr�m ◽  
Hans Ehrsson
Keyword(s):  
Cerebrospinal Fluid ◽  
Guinea Pig ◽  
Intravenous Administration

Distribution of cisplatin in perilymph and cerebrospinal fluid after intravenous administration in the guinea pig

1995 ◽  
Vol 36 (1) ◽  
pp. 83-86
Author(s):  
G. Laurell ◽  
Anita Andersson ◽  
Berit Engstr�m ◽  
Hans Ehrsson
Keyword(s):  
Cerebrospinal Fluid ◽  
Guinea Pig ◽  
Intravenous Administration

The Effects of Modulation of Prostanoid Metabolism on the Thoracic Platelet Accumulation Induced by Intravenous Administration of Collagen in the Guinea-Pig

1986 ◽  
Vol 56 (03) ◽  
pp. 263-267
Author(s):  
K D Butler ◽  
R A Shand ◽  
R B Wallis
Keyword(s):  
Platelet Count ◽  
Guinea Pig ◽  
Intravenous Administration ◽  
Cyclooxygenase Inhibitors ◽  
Concomitant Increase ◽  
Thromboxane Synthetase ◽  
Platelet Accumulation ◽  
Related Increase

SummaryThe effects of intravenously administered collagen on the circulatory platelet count, TxB2, 6-keto PGF1α and 51Cr-labelled platelet accumulation in the thorax have been evaluated in the guinea-pig. Administration of collagen induced a dose-related peripheral thrombocytopenia and a concomitant increase in 51Cr-labelled platelets in the thorax. There was also a transient dose-related increase in plasma TxB2 but no change in plasma 6-keto PGF1α levels.The thromboxane synthetase inhibitors tested, reduced the platelet accumulation, but only CGS 13080 significantly inhibited TxB2 production. In contrast all the cyclooxygenase inhibitors tested impaired the elevation of plasma TxB2 after collagen, but only diclofenac inhibited the 51Cr-labelled platelet accumulation.The greater effect of thromboxane synthetase inhibitors compared to cyclooxygenase inhibitors on platelet accumulation in this system cannot be completely explained by the changes measured in the circulating prostanoids.

Cerebrospinal Fluid Distribution of Ibuprofen After Intravenous Administration in Children

PEDIATRICS ◽  
2007 ◽  
Vol 120 (4) ◽  
pp. e1002-e1008 ◽  
Author(s):  
H. Kokki ◽  
E. Kumpulainen ◽  
M. Lehtonen ◽  
M. Laisalmi ◽  
M. Heikkinen ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Intravenous Administration ◽  
Fluid Distribution

K, Cl, and H2O entry in endolymph, perilymph, and cerebrospinal fluid of the rat

1982 ◽  
Vol 243 (2) ◽  
pp. F173-F180 ◽  
Author(s):  
O. Sterkers ◽  
G. Saumon ◽  
P. Tran Ba Huy ◽  
C. Amiel
Keyword(s):  
Cerebrospinal Fluid ◽  
Potassium Chloride ◽  
Intravenous Administration ◽  
Compartmental Analysis ◽  
Water Entry ◽  
Scala Tympani ◽  
Rapid Turnover ◽  
Kinetics Of ◽  
Scala Vestibuli

The kinetics of radioactive potassium, chloride, and water entry into endolymph, perilymph, and cerebrospinal fluid were studied after intravenous administration of tracers in anesthetized and nephrectomized rats. Samples of cochlear endolymph, perilymph of scala vestibuli, perilymph of scala tympani, and cisternal cerebrospinal fluid were obtained. The data showed: 1) a rapid turnover of water in endolymph, perilymph, and cerebrospinal fluid, since 3H2O equilibrated with plasma in a few minutes; 2) a slow entry of 42K and 36Cl in perilymph, since 36Cl equilibrated with plasma after 2 h and 42K did not at 6 h; 3) an extremely slow entry of 42K and 36Cl in endolymph, since no equilibrium with plasma was obtained within the 5 h of the experiments. The comparison of the compartmental analysis of our data with the results of other studies using perilymphatic perfusion of tracers indicated that perilymph rather than plasma may be considered as the precursor of endolymph.

Facilitated transfer of glucose from blood into perilymph in the rat cochlea

1987 ◽  
Vol 253 (1) ◽  
pp. F59-F65 ◽  
Author(s):  
E. Ferrary ◽  
O. Sterkers ◽  
G. Saumon ◽  
P. Tran Ba Huy ◽  
C. Amiel
Keyword(s):  
Cerebrospinal Fluid ◽  
Linear Function ◽  
Intravenous Administration ◽  
Glucose Concentration ◽  
Concentration Ratio ◽  
Facilitated Transport ◽  
Scala Tympani ◽  
Glucose Transfer ◽  
Rat Cochlea ◽  
Scala Vestibuli

The transport of glucose into cochlear endolymph, perilymph of scala vestibuli and perilymph of scala tympani, and cerebrospinal fluid (CSF) was studied after intravenous administration of tracers of D-glucose, L-glucose, and 3-O-methyl-D-glucose in anesthetized rats. The data showed that D-glucose concentrations in perilymph of scala vestibuli, perilymph of scala tympani, and CSF were approximately 50%, and in endolymph less than 10%, that in plasma; D-glucose concentration in perilymph of scala vestibuli, perilymph of scala tympani, and CSF increased as a linear function of that in plasma; D-glucose entry into perilymph of scala vestibuli, perilymph of scala tympani, and CSF was more rapid than that of L-glucose; after infusion of 3-O-methyl-D-glucose, but not after that of mannitol, both the D-glucose concentration ratio of perilymph over plasma and D-glucose transfer into perilymph were lowered. These results indicate that D-glucose enters into perilymph of scala vestibuli by a facilitated transport, possibly located at the blood-perilymph barrier.

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