Breast cancer: prognostic significance of c-erb-B2 and int-2 amplification compared with DNA ploidy, S-phase fraction, and conventional clinicopathological features

1994 ◽  
Vol 29 (3) ◽  
pp. 237-245 ◽  
Author(s):  
Ulf L�nn ◽  
Sigrid L�nn ◽  
Bo Nilsson ◽  
Bj�rn Stenkvist
Keyword(s):  
Breast Cancer ◽  
Dna Ploidy ◽  
Prognostic Significance ◽  
S Phase ◽  
Clinicopathological Features ◽  
Phase Fraction

scholarly journals Lack of prognostic significance of DNA ploidy and S phase fraction in breast cancer

1992 ◽  
Vol 66 (5) ◽  
pp. 925-929 ◽  
Author(s):  
PD Stanton ◽  
TG Cooke ◽  
SJ Oakes ◽  
J Winstanley ◽  
S Holt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Ploidy ◽  
Prognostic Significance ◽  
S Phase ◽  
Phase Fraction

scholarly journals Evaluation of Prognostic Factors Following Flow-Cytometric DNA Analysis after Cytokeratin Labelling: I. Breast Cancer

2002 ◽  
Vol 24 (4-5) ◽  
pp. 135-145 ◽  
Author(s):  
Pauline Wimberger ◽  
Peter Hillemanns ◽  
Thomas Kapsner ◽  
Hermann Hepp ◽  
Rainer Kimmig
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Tumor Cells ◽  
Dna Ploidy ◽  
Gynecologic Oncology ◽  
Univariate Analysis ◽  
Prognostic Significance ◽  
S Phase ◽  
Phase Fraction ◽  
Flow Cytometric

In gynecologic oncology valid prognostic factors are necessary to estimate the course of disease and to define biologically similar subgroups for analysis of therapeutic efficacy. The presented study is a prospective study concerning prognostic significance of DNA ploidy and S‐phase fraction in breast cancer following enrichment of tumor cells by cytokeratin labelling. Epithelial cells were labeled by FITC‐conjugated cytokeratin antibody (CK 5, 6, 8, and CK 17) prior to flow cytometric cell cycle analysis in 327 fresh specimens of primary breast cancer. Univariate analysis in breast cancer detected the prognostic significance of DNA‐ploidy, S‐phase fraction and CV (coefficient of variation) of G0G1‐peak of tumor cells for clinical outcome, especially for nodal‐negative patients. Multivariate analysis could not confirm prognostic evidence of DNA‐ploidy and S‐phase fraction. In conclusion, in breast cancer no clinical significance for determination of DNA‐parameters was found.

S-phase fraction is a prognostic factor in stage I breast carcinoma.

1993 ◽  
Vol 11 (9) ◽  
pp. 1717-1722 ◽  
Author(s):  
O Stål ◽  
M Dufmats ◽  
T Hatschek ◽  
J Carstensen ◽  
C Klintenberg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Dna Content ◽  
Cancer Survival ◽  
Prognostic Significance ◽  
Breast Cancer Survival ◽  
S Phase ◽  
Stage I ◽  
Phase Fraction ◽  
Breast Cancer Patients

PURPOSE AND METHODS The prognostic significance of cell proliferation, estimated as cytometric S-phase fraction (SPF), was investigated in node-negative breast cancer patients with small tumors (T1, NO). The 219 stage I patients originated from two series and were diagnosed either from 1978 to 1981 or from 1981 to 1985. The tumors were analyzed for estrogen receptors (ERs) by isoelectric focusing and for cellular DNA content by static cytofluorometry or flow cytometry. RESULTS A high SPF correlated with the absence of ERs and abnormal DNA content, and was less often found in tumors smaller than 11 mm compared with those with a diameter between 11 and 20 mm. Among the variables age, tumor size, DNA ploidy, ER status, and SPF, only SPF showed a significant association with distant recurrence and breast cancer survival in systemically untreated patients. The relative recurrence rate for patients with an SPF of 10% or greater was three times that for patients with lower SPFs. Estimated 8-year breast cancer survival rates for the same groups were 72% and 91%, respectively. CONCLUSION This study suggests that cytometric SPF has prognostic significance in stage I breast carcinoma.

Linell Classification of Breast Cancer Morphology Compared to Histologic Grading, S-Phase Fraction and DNA-Ploidy

1997 ◽  
Vol 193 (7) ◽  
pp. 485-490
Author(s):  
Jan Söderström ◽  
Conny Arnerlöv ◽  
Stefan O. Emdin ◽  
Bengt Lundgren ◽  
Göran Roos ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Ploidy ◽  
S Phase ◽  
Phase Fraction ◽  
Histologic Grading

Relationship of DNA Ploidy and S-Phase Fraction to Survival After First Recurrence of Breast Cancer

1994 ◽  
Vol 33 (4) ◽  
pp. 423-429 ◽  
Author(s):  
Olle Stal ◽  
John M. Carstensen ◽  
Sten Wingren ◽  
Lars Erik Rutqvist ◽  
Lambert Skoog ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Ploidy ◽  
S Phase ◽  
Phase Fraction ◽  
First Recurrence ◽  
Relationship Of

Prognostic significance of DNA ploidy, S-phase fraction, and P-glycoprotein expression in colorectal cancer

1999 ◽  
Vol 72 (3) ◽  
pp. 167-174 ◽  
Author(s):  
Antonieta Salud ◽  
Jos� M. Porcel ◽  
Bhavna Raikundalia ◽  
Richard S. Camplejohn ◽  
Nick A. Taub
Keyword(s):  
Colorectal Cancer ◽  
Dna Ploidy ◽  
Prognostic Significance ◽  
S Phase ◽  
Phase Fraction ◽  
P Glycoprotein

Prognostic Significance of DNA Aneuploidy and p21ras Oncoprotein Expression in Colorectal Cancer and Their Role in the Determination of Treatment Modalities

2001 ◽  
Vol 16 (2) ◽  
pp. 97-104 ◽  
Author(s):  
N.H. Karelia ◽  
D.D. Patel ◽  
N.S. Desai ◽  
H.V. Mehta ◽  
P.K. Yadav ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Ploidy ◽  
Early Stage ◽  
Prognostic Significance ◽  
S Phase ◽  
Response To Therapy ◽  
Phase Fraction ◽  
Treatment Modalities ◽  
Early Stage Disease ◽  
Stage Disease

The purpose of the present study was to investigate the prognostic significance of DNA ploidy, S-phase fraction and p21ras oncoprotein expression in patients with colorectal cancer and to correlate these factors with the clinical behavior of the tumors and their response to therapy. Of 79 patients with colorectal cancer 57% (45/79) had early stage disease. Forty-one percent (32/79) had aneuploid tumors while 30% (24/79) of the tumors had a high (>10%) S-phase fraction. p21ras oncoprotein expression was detected in 38% (30/79) of tumors. Patients with aneuploid tumors had a worse prognosis than patients with diploid tumors (p=0.0002). Similarly, patients with high S-phase fraction tumors had a shorter survival than those with low S-phase fraction tumors (p=0.005). No such difference was found between p21ras-positive and p21ras-negative tumor subgroups. In early stage colorectal cancer, aneuploidy was closely correlated with disease outcome (p=0.029). Early stage patients with diploid tumors who received radiotherapy and chemotherapy had a better prognosis than patients with aneuploid tumors. In conclusion, DNA ploidy is a significant and independent prognostic factor in colorectal cancer. Aneuploidy and genetic alteration of the p21ras oncoprotein are important in determining the biological aggressiveness of colorectal cancer. Furthermore, DNA ploidy may identify those subgroups of patients with early stage disease who may benefit from more aggressive treatment.

scholarly journals Do DNA ploidy and S-phase fraction in primary tumour predict the response to chemotherapy in metastatic breast cancer?

1995 ◽  
Vol 71 (5) ◽  
pp. 1029-1032 ◽  
Author(s):  
P Hietanen ◽  
C Blomqvist ◽  
V-M Wasenius ◽  
E Niskanen ◽  
K Franssila ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Dna Ploidy ◽  
Primary Tumour ◽  
Metastatic Breast ◽  
S Phase ◽  
Phase Fraction ◽  
Response To Chemotherapy
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