The crystal and molecular structure of the ?-cyclodextrin inclusion complex with aspirin and salicylic acid

1984 ◽  
Vol 2 (3-4) ◽  
pp. 701-714 ◽  
Author(s):  
Fumio Nishioka ◽  
Isao Nakanishi ◽  
Takaji Fujiwara ◽  
Ken-ichi Tomita
Keyword(s):  
Molecular Structure ◽  
Salicylic Acid ◽  
Inclusion Complex ◽  
Crystal And Molecular Structure ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex

Crystal and molecular structure of β-cyclodextrin inclusion complex with succinic acid

2007 ◽  
Vol 58 (3-4) ◽  
pp. 367-375 ◽  
Author(s):  
Yuriy V. Lisnyak ◽  
Arthur V. Martynov ◽  
Vyacheslav N. Baumer ◽  
Oleg V. Shishkin ◽  
Anna V. Gubskaya
Keyword(s):  
Molecular Structure ◽  
Inclusion Complex ◽  
Succinic Acid ◽  
Crystal And Molecular Structure ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex

scholarly journals Comprehensive Characterisation of the Ketoprofen-β-Cyclodextrin Inclusion Complex Using X-ray Techniques and NMR Spectroscopy

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 4089
Author(s):  
Katarzyna Betlejewska-Kielak ◽  
Elżbieta Bednarek ◽  
Armand Budzianowski ◽  
Katarzyna Michalska ◽  
Jan K. Maurin
Keyword(s):  
Nmr Spectroscopy ◽  
Inclusion Complex ◽  
Crystal And Molecular Structure ◽  
Binding Constants ◽  
Nmr Studies ◽  
X Ray ◽  
Cyclodextrin Inclusion ◽  
Powder Samples ◽  
Cyclodextrin Inclusion Complex ◽  
Co Precipitation

Racemic ketoprofen (KP) and β-cyclodextrin (β-CD) powder samples from co-precipitation (1), evaporation (2), and heating-under-reflux (3) were analysed using X-ray techniques and nuclear magnetic resonance (NMR) spectroscopy. On the basis of NMR studies carried out in an aqueous solution, it was found that in the samples obtained by methods 1 and 2, there were large excesses of β-CD in relation to KP, 10 and 75 times, respectively, while the sample obtained by method 3 contained equimolar amounts of β-CD and KP. NMR results indicated that KP/β-CD inclusion complexes were formed and the estimated binding constants were approximately 2400 M−1, showing that KP is quite strongly associated with β-CD. On the other hand, the X-ray single-crystal technique in the solid state revealed that the (S)-KP/β-CD inclusion complex with a stoichiometry of 2:2 was obtained as a result of heating-under-reflux, for which the crystal and molecular structure were examined. Among the methods used for the preparation of the KP/β-CD complex, only method 3 is suitable.

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