Methyl palmitate prevents Kupffer cell activation and improves survival after orthotopic liver transplantation in the rat

1991 ◽  
Vol 4 (4) ◽  
pp. 215-220 ◽  
Author(s):  
Ingo Marzi ◽  
Katherine Cowper ◽  
Yoshiyuki Takei ◽  
Kelly Lindert ◽  
John J. Lemasters ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Kupffer Cell ◽  
Methyl Palmitate ◽  
Cell Activation

Methyl palmitate prevents Kupffer cell activation and improves survival after orthotopic liver transplantation in the rat

1991 ◽  
Vol 4 (1) ◽  
pp. 215-220 ◽  
Author(s):  
Ingo Marzi ◽  
Katherine Cowper ◽  
Yoshiyuki Takei ◽  
Kelly Lindert ◽  
John J. Lemasters ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Kupffer Cell ◽  
Methyl Palmitate ◽  
Cell Activation

Macrophage activation and leukocyte adhesion after liver transplantation

1993 ◽  
Vol 265 (1) ◽  
pp. G172-G177 ◽  
Author(s):  
I. Marzi ◽  
F. Walcher ◽  
V. Buhren
Keyword(s):  
Liver Transplantation ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Kupffer Cell ◽  
Kupffer Cells ◽  
Cell Activation ◽  
Channel Blocker ◽  
Leukocyte Adhesion ◽  
Cell Activity ◽  
Phagocytic Cells

Reperfusion injury involving oxygen radicals, leukocyte adhesion, and Kupffer cell activation has been suggested to contribute to the failure of transplanted livers. The aim of this study was to evaluate Kupffer cell activity, leukocyte adhesion, and the effect of the calcium channel blocker nisoldipine after rat liver transplantation by means of in vivo fluorescence microscopy to further investigate the mechanism of graft failure. Inclusion of 1.4 microM nisoldipine to the University of Wisconsin cold storage solution (UW) did not improve sinusoidal perfusion and vasoconstriction after transplantation compared with UW alone (82.7 +/- 1.0% vs. 79.2 +/- 1.7% perfused sinusoids; 7.3 +/- 0.1 vs. 8.0 +/- 0.2 microns diam of sinusoids; means +/- SE). Permanent as well as temporary adhesion of leukocytes rose from 9.4 +/- 0.8 and 10.2 +/- 0.5% in sham-operated controls to 19.1 +/- 2.2 and 19.2 +/- 0.5% after liver transplantation, respectively. Inclusion of the calcium channel blocker reduced permanent (9.1 +/- 0.8%; P < 0.05) and temporary adherent leukocytes (11.3 +/- 1.0%; P < 0.05). Phagocytosis of latex beads by Kupffer cells or other phagocytic cells as a function of activity rose after transplantation (e.g., periportal area: 509 +/- 44/mm2) compared with controls (316 +/- 22/mm2). This was significantly reduced by inclusion of nisoldipine to UW (322 +/- 32/mm2). The results of this study demonstrate activation of Kupffer cells and increase of leukocyte adhesion to the sinusoidal endothelial wall during reperfusion of transplanted livers. A calcium-dependent release of mediators by Kupffer cells that promote leukocyte adhesion is suggested as an underlying mechanism.

scholarly journals Primary graft nonfunction and Kupffer cell activation after liver transplantation from non-heart-beating donors in pigs

2007 ◽  
Vol 13 (2) ◽  
pp. 239-247 ◽  
Author(s):  
Diethard Monbaliu ◽  
Jos van Pelt ◽  
Rita De Vos ◽  
Joanne Greenwood ◽  
Jaakko Parkkinen ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Kupffer Cell ◽  
Cell Activation ◽  
Heart Beating ◽  
Primary Graft Nonfunction

Effect of nutritional procurement for the donor liver on Kupffer cell activation in porcine liver transplantation

1997 ◽  
Vol 29 (8) ◽  
pp. 3357 ◽  
Author(s):  
T. Ishikawa ◽  
T. Yagi ◽  
N. Ishido ◽  
K. Fujisawa ◽  
H. Matsuda ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Kupffer Cell ◽  
Cell Activation ◽  
Donor Liver ◽  
Porcine Liver ◽  
Porcine Liver Transplantation

Kupffer cell activation by LPS is mediated via LPS binding protein and CD14

2001 ◽  
Vol 120 (5) ◽  
pp. A27-A27
Author(s):  
M FAN ◽  
S GOYERT ◽  
A AMINLARI ◽  
R KLEIN ◽  
L STEINSTRAESSER ◽  
...  
Keyword(s):  
Kupffer Cell ◽  
Cell Activation ◽  
Binding Protein ◽  
Lps Binding
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