Mechanisms of anticonvulsant drug action

1987 ◽  
Vol 146 (1) ◽  
pp. 8-14 ◽  
Author(s):  
C. L. Faingold ◽  
R. A. Browning
Keyword(s):  
Anticonvulsant Drug ◽  
Drug Action

Stereochemical basis of anticonvulsant drug action. VI. Crystal and molecular structure of diphenylsilanediol

1977 ◽  
Vol 55 (20) ◽  
pp. 3631-3635 ◽  
Author(s):  
J. Keith Fawcett ◽  
Norman Camerman ◽  
Arthur Camerman
Keyword(s):  
Molecular Structure ◽  
Phenyl Ring ◽  
Anticonvulsant Activity ◽  
Crystal And Molecular Structure ◽  
Anticonvulsant Drug ◽  
Drug Action ◽  
Asymmetric Unit ◽  
Triclinic Space Group ◽  
Fourier Methods ◽  
Cell Dimensions

The crystal and molecular structure of diphenylsilanediol, a compound with recently demonstrated anticonvulsant activity, has been determined and its stereochemistry compared with other antiepileptics. Crystals of diphenylsilanediol are triclinic, space group [Formula: see text] with cell dimensions a = 9.912, b = 15.048, c = 14.519 Å, α = 120.83,β = 99.95, γ = 100.84°, Z = 6 molecules per cell (3 molecules per asymmetric unit). The structure was determined by Patterson and Fourier methods and refined to a final discrepancy value R = 0.034. The phenyl ring planes in the molecule are rotated by 80° with respect to each other, and the hydroxyl oxygen atoms are 2.66 Å apart. The molecular parameters help to delineate limits of stereochemical variation in these molecules with retention of anticonvulsant activity.

scholarly journals Cellular Bases of Barbiturate and Phenytoin Anticonvulsant Drug Action

Epilepsia ◽  
1982 ◽  
Vol 23 (s1) ◽  
pp. S7-S18 ◽  
Author(s):  
Robert L. Macdonald ◽  
Michael J. McLean
Keyword(s):  
Anticonvulsant Drug ◽  
Drug Action
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