Pharmacokinetics and effects on blood pressure of a single oral dose of milrinone in healthy subjects and in patients with renal impairment

1986 ◽  
Vol 29 (5) ◽  
pp. 549-553 ◽  
Author(s):  
R. Larsson ◽  
H. Liedholm ◽  
K. E. Andersson ◽  
M. A. Keane ◽  
G. Henry
Keyword(s):  
Blood Pressure ◽  
Renal Impairment ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Healthy Subjects

scholarly journals Sparfloxacin Distribution in Human Saliva

2020 ◽  
Vol 6 (2) ◽  
Author(s):  
Kolaci M ◽  
Deda L
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Healthy Subjects ◽  
Human Saliva

Aim: The aim of this study is to assess the penetration of sparfloxacin in mixed human saliva after a single oral dose of 400mg in Caucasian healthy subjects.

scholarly journals Pulmonary Vasodilation by Sildenafil in Acute Pulmonary Embolism—A Randomized Explorative Trial

2020 ◽  
Author(s):  
Asger Andersen ◽  
Farhad Waziri ◽  
Jacob Gammelgaard Schultz ◽  
Sarah Holmboe ◽  
Søren Warberg Becker ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pulmonary Embolism ◽  
High Risk ◽  
Cardiac Index ◽  
Oral Dose ◽  
Right Ventricular ◽  
Single Oral Dose ◽  
Ventricular Function ◽  
Right Ventricular Function ◽  
Pulmonary Vasodilation

Abstract Background: To investigate if acute pulmonary vasodilation by sildenafil improves right ventricular function in patients with acute intermediate-high risk pulmonary embolism (PE).Methods: Patients with PE were randomized to a single oral dose of sildenafil 50mg (n=10) or placebo (n=10) as add-on to conventional therapy. Right ventricular function was evaluated immediately before and shortly after (0.5-1.5h) randomization by right heart catheterization (RHC), trans-thoracic echocardiography (TTE), and cardiac magnetic resonance (CMR). The primary efficacy endpoint was cardiac index measured by CMR.Results: Patients had acute intermediate-high risk PE verified by computed tomography pulmonary angiography, systolic blood pressure of 135 ± 18 (mean ± SD) mmHg, increased right ventricular/left ventricular ratio 1.1 ± 0.09 and increased troponin T 167 ± 144 ng/L. Sildenafil treatment did not improve cardiac index compared to baseline (0.02 ± 0.36 l/min/m2, p=0.89) and neither did placebo (0.00 ± 0.34 l/min/m2, p=0.97).Conclusion: A single oral dose of 50 mg sildenafil did not improve cardiac index but lowered systemic blood pressure in patients with acute intermediate-high risk PE.Trial Registration: The trial was retrospectively registered at www.clinicaltrials.gov (NCT04283240) February 2nd 2020, https://clinicaltrials.gov/ct2/show/NCT04283240?term=NCT04283240&draw=2&rank=1

Absorption; metabolism and excretion of a single oral dose of 14c-paliperidone 1mg in healthy subjects (PAL-053)

2007 ◽  
Vol 40 (05) ◽  
Author(s):  
M Vermeir ◽  
S Boom ◽  
I Naessens ◽  
K Talluri ◽  
M Eerdekens ◽  
...  
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Healthy Subjects
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